Urinary neonicotinoid concentrations and pubertal development in Chinese adolescents: A cross-sectional study
Background: Animal studies suggest that exposure to certain neonicotinoids may interfere with the normal function of endocrine system in mammals. However, evidence from human studies is limited. Objectives: This study conducted a cross-sectional analysis to examine urinary neonicotinoids concentrati...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S016041202200112X |
| _version_ | 1818023513701744640 |
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| author | Min Yue Qin Liu Feng Wang Wenli Zhou Liying Liu Lu Wang Yong Zou Liyu Zhang Meilin Zheng Shaohua Zeng Jieying Gao |
| author_facet | Min Yue Qin Liu Feng Wang Wenli Zhou Liying Liu Lu Wang Yong Zou Liyu Zhang Meilin Zheng Shaohua Zeng Jieying Gao |
| author_sort | Min Yue |
| collection | DOAJ |
| description | Background: Animal studies suggest that exposure to certain neonicotinoids may interfere with the normal function of endocrine system in mammals. However, evidence from human studies is limited. Objectives: This study conducted a cross-sectional analysis to examine urinary neonicotinoids concentrations in Chinese adolescents and its association with pubertal development. Methods: 774 urine samples from 439 boys (median age: 13.7 years; 25th-75th percentile: 12.7-14.5 years) and 335 girls (median age: 13.7 years; 25th-75th percentile: 12.7–14.5 years) were collected for determination of ten neonicotinoids (imidacloprid, nitenpyram, acetamiprid, thiacloprid, imidaclothiz, thiamethoxam, clothianidin, dinotefuran, flonicamid, sulfoxaflor) and one metabolite (N-desmethyl-acetamiprid). Urinary creatinine was detected for concentration adjustment. Pubertal development including pubic hair, axillary hair, genitalia (boys), testicular volume (boys) and breast (girls) assessed by Tanner stages and others (spermarche, facial hair for boys and menarche for girls) were obtained by physical examination and questionnaire. Logistic and bayesian kernel machine regression were used to investigate the association between neonicotinoids concentrations and pubertal developments. Results: High detection rates ranged from 72.0% to 100.0% for all neonicotinoids. Boys and girls with thiacloprid concentration at the >75th percentile had lower stage of genitalia development (OR: 0.83, 95% CI: 0.33–0.93) and higher stage of axillary hair development (OR: 1.46, 95% CI: 1.12–3.41), respectively, compared with those at the <25th percentile. The estimate change in genitalia stage was significantly different at or above the 75th percentile concentration of neonicotinoids mixture compared to the 50th percentile concentration. No associations were found between other urinary neonicotinoids and other indicators of puberty. Conclusions: Higher thiacloprid concentration was associated with delayed genitalia development in boys and early axillary hair development in girls. Neonicotinoids mixture was negatively associated with genitalia stage in the joint effect. Given the characteristic of the cross-sectional study, our results need further confirmation of the causal relationship. |
| first_indexed | 2024-12-10T03:45:31Z |
| format | Article |
| id | doaj.art-3c110177fdd44bfba4d2c4ef6152f961 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-10T03:45:31Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-3c110177fdd44bfba4d2c4ef6152f9612022-12-22T02:03:27ZengElsevierEnvironment International0160-41202022-05-01163107186Urinary neonicotinoid concentrations and pubertal development in Chinese adolescents: A cross-sectional studyMin Yue0Qin Liu1Feng Wang2Wenli Zhou3Liying Liu4Lu Wang5Yong Zou6Liyu Zhang7Meilin Zheng8Shaohua Zeng9Jieying Gao10School of Public Health and Management, Chongqing Medical University, Chongqing 400016, PR ChinaSchool of Public Health and Management, Chongqing Medical University, Chongqing 400016, PR ChinaChongqing Nan’an Center for Disease Control and Prevention, Chongqing 400067, PR ChinaSchool of Public Health and Management, Chongqing Medical University, Chongqing 400016, PR ChinaChongqing Nan’an Center for Disease Control and Prevention, Chongqing 400067, PR ChinaChongqing Nan’an Center for Disease Control and Prevention, Chongqing 400067, PR ChinaSchool of Public Health and Management, Chongqing Medical University, Chongqing 400016, PR ChinaSchool of Public Health and Management, Chongqing Medical University, Chongqing 400016, PR ChinaSchool of Public Health and Management, Chongqing Medical University, Chongqing 400016, PR ChinaChina Coal Technology & Engineering Group Chongqing Research Institute, Chongqing 400039, PR ChinaSchool of Public Health and Management, Chongqing Medical University, Chongqing 400016, PR China; Corresponding author.Background: Animal studies suggest that exposure to certain neonicotinoids may interfere with the normal function of endocrine system in mammals. However, evidence from human studies is limited. Objectives: This study conducted a cross-sectional analysis to examine urinary neonicotinoids concentrations in Chinese adolescents and its association with pubertal development. Methods: 774 urine samples from 439 boys (median age: 13.7 years; 25th-75th percentile: 12.7-14.5 years) and 335 girls (median age: 13.7 years; 25th-75th percentile: 12.7–14.5 years) were collected for determination of ten neonicotinoids (imidacloprid, nitenpyram, acetamiprid, thiacloprid, imidaclothiz, thiamethoxam, clothianidin, dinotefuran, flonicamid, sulfoxaflor) and one metabolite (N-desmethyl-acetamiprid). Urinary creatinine was detected for concentration adjustment. Pubertal development including pubic hair, axillary hair, genitalia (boys), testicular volume (boys) and breast (girls) assessed by Tanner stages and others (spermarche, facial hair for boys and menarche for girls) were obtained by physical examination and questionnaire. Logistic and bayesian kernel machine regression were used to investigate the association between neonicotinoids concentrations and pubertal developments. Results: High detection rates ranged from 72.0% to 100.0% for all neonicotinoids. Boys and girls with thiacloprid concentration at the >75th percentile had lower stage of genitalia development (OR: 0.83, 95% CI: 0.33–0.93) and higher stage of axillary hair development (OR: 1.46, 95% CI: 1.12–3.41), respectively, compared with those at the <25th percentile. The estimate change in genitalia stage was significantly different at or above the 75th percentile concentration of neonicotinoids mixture compared to the 50th percentile concentration. No associations were found between other urinary neonicotinoids and other indicators of puberty. Conclusions: Higher thiacloprid concentration was associated with delayed genitalia development in boys and early axillary hair development in girls. Neonicotinoids mixture was negatively associated with genitalia stage in the joint effect. Given the characteristic of the cross-sectional study, our results need further confirmation of the causal relationship.http://www.sciencedirect.com/science/article/pii/S016041202200112XNeonicotinoidsTanner stagesAdolescentsPubertal development |
| spellingShingle | Min Yue Qin Liu Feng Wang Wenli Zhou Liying Liu Lu Wang Yong Zou Liyu Zhang Meilin Zheng Shaohua Zeng Jieying Gao Urinary neonicotinoid concentrations and pubertal development in Chinese adolescents: A cross-sectional study Environment International Neonicotinoids Tanner stages Adolescents Pubertal development |
| title | Urinary neonicotinoid concentrations and pubertal development in Chinese adolescents: A cross-sectional study |
| title_full | Urinary neonicotinoid concentrations and pubertal development in Chinese adolescents: A cross-sectional study |
| title_fullStr | Urinary neonicotinoid concentrations and pubertal development in Chinese adolescents: A cross-sectional study |
| title_full_unstemmed | Urinary neonicotinoid concentrations and pubertal development in Chinese adolescents: A cross-sectional study |
| title_short | Urinary neonicotinoid concentrations and pubertal development in Chinese adolescents: A cross-sectional study |
| title_sort | urinary neonicotinoid concentrations and pubertal development in chinese adolescents a cross sectional study |
| topic | Neonicotinoids Tanner stages Adolescents Pubertal development |
| url | http://www.sciencedirect.com/science/article/pii/S016041202200112X |
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