Features of the Metabolic Profile of Saliva in Lung Cancer and COPD: The Effect of Smoking Status
The aim of the study was to compare the metabolic characteristics of the salivary composition in lung cancer, chronic obstructive pulmonary disease (COPD) and their combination, depending on the smoking history. The study group included 392 patients with lung cancer of various histological types. Th...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/11/5/289 |
| _version_ | 1797535553640464384 |
|---|---|
| author | Lyudmila V. Bel’skaya Elena A. Sarf Denis V. Solomatin Victor K. Kosenok |
| author_facet | Lyudmila V. Bel’skaya Elena A. Sarf Denis V. Solomatin Victor K. Kosenok |
| author_sort | Lyudmila V. Bel’skaya |
| collection | DOAJ |
| description | The aim of the study was to compare the metabolic characteristics of the salivary composition in lung cancer, chronic obstructive pulmonary disease (COPD) and their combination, depending on the smoking history. The study group included 392 patients with lung cancer of various histological types. The division into subgroups was carried out in accordance with the severity of COPD and smoking experience. Salivary biochemical composition was determined according to 34 indicators. For data processing, the principal component method was used. Different groups of biochemical saliva markers are informative when separately accounting for the smoking factor and the presence of COPD in lung cancer. For smoking, antioxidant enzymes and electrolyte components of saliva are informative; for COPD metabolic enzymes, lipid peroxidation products, sialic acids and electrolyte components are informative. While taking into account the smoking factor and the presence of COPD, biochemical markers corresponding to the presence/absence and severity of COPD are the priority. Changes occurring in the background of smoking are of a secondary nature, manifesting as much as possible with a smoking history of more than 50 pack-years. Thus, the metabolic changes that occur in lung cancer in combination with COPD, depending on the smoking factor, can be estimated using saliva. |
| first_indexed | 2024-03-10T11:47:02Z |
| format | Article |
| id | doaj.art-3c115b78c50b413f879a9990cbf46f53 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T11:47:02Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-3c115b78c50b413f879a9990cbf46f532023-11-21T17:59:26ZengMDPI AGMetabolites2218-19892021-04-0111528910.3390/metabo11050289Features of the Metabolic Profile of Saliva in Lung Cancer and COPD: The Effect of Smoking StatusLyudmila V. Bel’skaya0Elena A. Sarf1Denis V. Solomatin2Victor K. Kosenok3Biochemistry Research Laboratory, Omsk State Pedagogical University, 644099 Omsk, RussiaBiochemistry Research Laboratory, Omsk State Pedagogical University, 644099 Omsk, RussiaDepartment of Mathematics and Mathematical Education, Omsk State Pedagogical University, 644099 Omsk, RussiaDepartment of Oncology, Omsk State Medical University, 644099 Omsk, RussiaThe aim of the study was to compare the metabolic characteristics of the salivary composition in lung cancer, chronic obstructive pulmonary disease (COPD) and their combination, depending on the smoking history. The study group included 392 patients with lung cancer of various histological types. The division into subgroups was carried out in accordance with the severity of COPD and smoking experience. Salivary biochemical composition was determined according to 34 indicators. For data processing, the principal component method was used. Different groups of biochemical saliva markers are informative when separately accounting for the smoking factor and the presence of COPD in lung cancer. For smoking, antioxidant enzymes and electrolyte components of saliva are informative; for COPD metabolic enzymes, lipid peroxidation products, sialic acids and electrolyte components are informative. While taking into account the smoking factor and the presence of COPD, biochemical markers corresponding to the presence/absence and severity of COPD are the priority. Changes occurring in the background of smoking are of a secondary nature, manifesting as much as possible with a smoking history of more than 50 pack-years. Thus, the metabolic changes that occur in lung cancer in combination with COPD, depending on the smoking factor, can be estimated using saliva.https://www.mdpi.com/2218-1989/11/5/289lung cancerchronic obstructive pulmonary diseasesmokingsalivabiochemistrydiagnostics |
| spellingShingle | Lyudmila V. Bel’skaya Elena A. Sarf Denis V. Solomatin Victor K. Kosenok Features of the Metabolic Profile of Saliva in Lung Cancer and COPD: The Effect of Smoking Status Metabolites lung cancer chronic obstructive pulmonary disease smoking saliva biochemistry diagnostics |
| title | Features of the Metabolic Profile of Saliva in Lung Cancer and COPD: The Effect of Smoking Status |
| title_full | Features of the Metabolic Profile of Saliva in Lung Cancer and COPD: The Effect of Smoking Status |
| title_fullStr | Features of the Metabolic Profile of Saliva in Lung Cancer and COPD: The Effect of Smoking Status |
| title_full_unstemmed | Features of the Metabolic Profile of Saliva in Lung Cancer and COPD: The Effect of Smoking Status |
| title_short | Features of the Metabolic Profile of Saliva in Lung Cancer and COPD: The Effect of Smoking Status |
| title_sort | features of the metabolic profile of saliva in lung cancer and copd the effect of smoking status |
| topic | lung cancer chronic obstructive pulmonary disease smoking saliva biochemistry diagnostics |
| url | https://www.mdpi.com/2218-1989/11/5/289 |
| work_keys_str_mv | AT lyudmilavbelskaya featuresofthemetabolicprofileofsalivainlungcancerandcopdtheeffectofsmokingstatus AT elenaasarf featuresofthemetabolicprofileofsalivainlungcancerandcopdtheeffectofsmokingstatus AT denisvsolomatin featuresofthemetabolicprofileofsalivainlungcancerandcopdtheeffectofsmokingstatus AT victorkkosenok featuresofthemetabolicprofileofsalivainlungcancerandcopdtheeffectofsmokingstatus |