Serum Calprotectin and Iron Metabolism Biomarker Levels in Behçet’s Disease
Objective:This study aimed to investigate the serum levels of calprotectin, hepcidin, iron, and ferritin in Behçet’s disease (BD).Materials and Methods:This study included 40 patients with BD who met the diagnostic criteria of the BD International Study Group (1990) and 40 healthy control participan...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2021-12-01
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| Series: | Türk Osteoporoz Dergisi |
| Subjects: | |
| Online Access: |
http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/serum-calprotectin-and-ron-metabolism-biomarker-le/50613
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| _version_ | 1797923009565032448 |
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| author | Ahmet Karadağ Halef Okan Doğan |
| author_facet | Ahmet Karadağ Halef Okan Doğan |
| author_sort | Ahmet Karadağ |
| collection | DOAJ |
| description | Objective:This study aimed to investigate the serum levels of calprotectin, hepcidin, iron, and ferritin in Behçet’s disease (BD).Materials and Methods:This study included 40 patients with BD who met the diagnostic criteria of the BD International Study Group (1990) and 40 healthy control participants. Serum high-sensitive C-reactive protein (hsCRP), hepcidin, calprotectin, ferritin, iron, and unsaturated iron-binding capacity (UIBC) levels were determined in all study participants.Results:Statistically significant difference was found between the groups in respect of calprotectin (p<0.05), UIBC (p<0.05), hsCRP (p<0.05), and hemoglobin (p<0.05) levels. No statistically significant differences were determined between the patients and the controls in terms of hepcidin, iron, and ferritin levels. Cut-off value of 212.3 pg/mL for calprotectin was determined to identify patients with BD having a sensitivity and specificity of 100% and 90%, respectively.Conclusion:Serum calprotectin may be a useful biomarker in the evaluation of inflammatory status and BD diagnosis. Total iron-binding capacity and hemoglobin may be more useful in evaluating iron deficiency anemia in patients with BD. |
| first_indexed | 2024-04-10T14:40:09Z |
| format | Article |
| id | doaj.art-3c11bfc0fdab45049570df7a97de4033 |
| institution | Directory Open Access Journal |
| issn | 2147-2653 |
| language | English |
| last_indexed | 2024-04-10T14:40:09Z |
| publishDate | 2021-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Osteoporoz Dergisi |
| spelling | doaj.art-3c11bfc0fdab45049570df7a97de40332023-02-15T16:08:14ZengGalenos YayineviTürk Osteoporoz Dergisi2147-26532021-12-0127314014410.4274/tod.galenos.2021.4540313049054Serum Calprotectin and Iron Metabolism Biomarker Levels in Behçet’s DiseaseAhmet Karadağ0Halef Okan Doğan1 Sivas Cumhuriyet University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Sivas, Turkey Sivas Cumhuriyet University Faculty of Medicine, Department of Biochemistry, Sivas, Turkey Objective:This study aimed to investigate the serum levels of calprotectin, hepcidin, iron, and ferritin in Behçet’s disease (BD).Materials and Methods:This study included 40 patients with BD who met the diagnostic criteria of the BD International Study Group (1990) and 40 healthy control participants. Serum high-sensitive C-reactive protein (hsCRP), hepcidin, calprotectin, ferritin, iron, and unsaturated iron-binding capacity (UIBC) levels were determined in all study participants.Results:Statistically significant difference was found between the groups in respect of calprotectin (p<0.05), UIBC (p<0.05), hsCRP (p<0.05), and hemoglobin (p<0.05) levels. No statistically significant differences were determined between the patients and the controls in terms of hepcidin, iron, and ferritin levels. Cut-off value of 212.3 pg/mL for calprotectin was determined to identify patients with BD having a sensitivity and specificity of 100% and 90%, respectively.Conclusion:Serum calprotectin may be a useful biomarker in the evaluation of inflammatory status and BD diagnosis. Total iron-binding capacity and hemoglobin may be more useful in evaluating iron deficiency anemia in patients with BD. http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/serum-calprotectin-and-ron-metabolism-biomarker-le/50613 behçet’s diseasecalprotectinhepcidinironferritin |
| spellingShingle | Ahmet Karadağ Halef Okan Doğan Serum Calprotectin and Iron Metabolism Biomarker Levels in Behçet’s Disease Türk Osteoporoz Dergisi behçet’s disease calprotectin hepcidin iron ferritin |
| title | Serum Calprotectin and Iron Metabolism Biomarker Levels in Behçet’s Disease |
| title_full | Serum Calprotectin and Iron Metabolism Biomarker Levels in Behçet’s Disease |
| title_fullStr | Serum Calprotectin and Iron Metabolism Biomarker Levels in Behçet’s Disease |
| title_full_unstemmed | Serum Calprotectin and Iron Metabolism Biomarker Levels in Behçet’s Disease |
| title_short | Serum Calprotectin and Iron Metabolism Biomarker Levels in Behçet’s Disease |
| title_sort | serum calprotectin and iron metabolism biomarker levels in behcet s disease |
| topic | behçet’s disease calprotectin hepcidin iron ferritin |
| url |
http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/serum-calprotectin-and-ron-metabolism-biomarker-le/50613
|
| work_keys_str_mv | AT ahmetkaradag serumcalprotectinandironmetabolismbiomarkerlevelsinbehcetsdisease AT halefokandogan serumcalprotectinandironmetabolismbiomarkerlevelsinbehcetsdisease |