McKittrick–Wheelock Syndrome: A Case Report
An adenoma is the most typical large bowel tumor found in 30% of all screening colonoscopies. However, it is often asymptomatic but sometimes might lead to abdominal pain or bleeding of the rectum. Critical electrolyte disbalance and acute kidney injury caused by secretory diarrhea is an untypical c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/3/633 |
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| author | Kristina Marcinkevičiūtė Marius Kryžauskas Tomas Poškus |
| author_facet | Kristina Marcinkevičiūtė Marius Kryžauskas Tomas Poškus |
| author_sort | Kristina Marcinkevičiūtė |
| collection | DOAJ |
| description | An adenoma is the most typical large bowel tumor found in 30% of all screening colonoscopies. However, it is often asymptomatic but sometimes might lead to abdominal pain or bleeding of the rectum. Critical electrolyte disbalance and acute kidney injury caused by secretory diarrhea is an untypical clinical manifestation of adenoma. It has rarely been reported in the literature and is defined as McKittrick–Wheelock syndrome. A 61-year-old patient was hospitalized for heavy dyselectrolytemia, diarrhea, acute kidney injury, sepsis, and fever. After the renal function was corrected and electrolyte imbalance persisted, visual instrumental diagnostics tests revealed a large tumor in the sigmoid colon. Subsequently, the patient underwent surgical resection, which exhibited evidence of tubulovillous adenoma on pathology. The atypical signs of McKittrick–Wheelock syndrome and comorbidities can make the diagnostics challenging. When severe hyponatremia and hypokalemia are followed by persistent mucous diarrhea, the clinicians should suspect MWS as a possible reason for it. |
| first_indexed | 2024-03-11T06:12:10Z |
| format | Article |
| id | doaj.art-3c11d408688441f59997eaf083f941c9 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T06:12:10Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-3c11d408688441f59997eaf083f941c92023-11-17T12:33:27ZengMDPI AGMedicina1010-660X1648-91442023-03-0159363310.3390/medicina59030633McKittrick–Wheelock Syndrome: A Case ReportKristina Marcinkevičiūtė0Marius Kryžauskas1Tomas Poškus2Faculty of Medicine, Vilnius University, LT-03101 Vilnius, LithuaniaClinic of Gastroenterology, Nephrourology, and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, LT-03101 Vilnius, LithuaniaClinic of Gastroenterology, Nephrourology, and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, LT-03101 Vilnius, LithuaniaAn adenoma is the most typical large bowel tumor found in 30% of all screening colonoscopies. However, it is often asymptomatic but sometimes might lead to abdominal pain or bleeding of the rectum. Critical electrolyte disbalance and acute kidney injury caused by secretory diarrhea is an untypical clinical manifestation of adenoma. It has rarely been reported in the literature and is defined as McKittrick–Wheelock syndrome. A 61-year-old patient was hospitalized for heavy dyselectrolytemia, diarrhea, acute kidney injury, sepsis, and fever. After the renal function was corrected and electrolyte imbalance persisted, visual instrumental diagnostics tests revealed a large tumor in the sigmoid colon. Subsequently, the patient underwent surgical resection, which exhibited evidence of tubulovillous adenoma on pathology. The atypical signs of McKittrick–Wheelock syndrome and comorbidities can make the diagnostics challenging. When severe hyponatremia and hypokalemia are followed by persistent mucous diarrhea, the clinicians should suspect MWS as a possible reason for it.https://www.mdpi.com/1648-9144/59/3/633McKittrick–Wheelock syndromeelectrolyte imbalancetubulovillous adenomavillous adenoma |
| spellingShingle | Kristina Marcinkevičiūtė Marius Kryžauskas Tomas Poškus McKittrick–Wheelock Syndrome: A Case Report Medicina McKittrick–Wheelock syndrome electrolyte imbalance tubulovillous adenoma villous adenoma |
| title | McKittrick–Wheelock Syndrome: A Case Report |
| title_full | McKittrick–Wheelock Syndrome: A Case Report |
| title_fullStr | McKittrick–Wheelock Syndrome: A Case Report |
| title_full_unstemmed | McKittrick–Wheelock Syndrome: A Case Report |
| title_short | McKittrick–Wheelock Syndrome: A Case Report |
| title_sort | mckittrick wheelock syndrome a case report |
| topic | McKittrick–Wheelock syndrome electrolyte imbalance tubulovillous adenoma villous adenoma |
| url | https://www.mdpi.com/1648-9144/59/3/633 |
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