Effect of obesity on airway mechanics
Background: Obesity is known to induce lung function impairment. Previous studies of decline in lung function associated with obesity are well established. Materials and Methods: In this cross-sectional study, to evaluate the effects of different obesity indices on lung mechanics, healthy subjects (...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2023;volume=27;issue=2;spage=161;epage=166;aulast=Shanmugasundaram |
| _version_ | 1827944905814573056 |
|---|---|
| author | Kumar Shanmugasundaram Geetanjali Bade Meghashree Sampath Anjana Talwar |
| author_facet | Kumar Shanmugasundaram Geetanjali Bade Meghashree Sampath Anjana Talwar |
| author_sort | Kumar Shanmugasundaram |
| collection | DOAJ |
| description | Background: Obesity is known to induce lung function impairment. Previous studies of decline in lung function associated with obesity are well established. Materials and Methods: In this cross-sectional study, to evaluate the effects of different obesity indices on lung mechanics, healthy subjects (males-23 and females-22) were recruited. Anthropometric parameters like body mass index (BMI), waist circumference (WC), hip circumference (HC) and neck circumference (NC) were measured and waist-hip ratio (WHR) was derived. Spirometry, impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO) measurements were performed to assess lung function. Subgroups were divided and analysed. Results: In males, increased WHR is associated with increased total airway resistance (R5). BMI correlates positively with R5, R5% predicted, resistance at 20 Hz (R20) and R20% predicted; likewise, WHR shows a positive correlation with R5. In females, increased WHR has significantly higher R5, R5% predicted, R20, R20% predicted, area of reactance (Ax), resonant frequency (Fres) and decreased reactance at 5 Hz (X5), reactance at 20 Hz (X20), X20% predicted. The female group with higher WC shows significantly increased R5, R5% predicted, R20, R20% predicted, Ax, Fres and lower fixed ratio of forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC), X5, X20, X20% predicted. The group with higher NC has a lower FEV1/FVC ratio. WHR positively correlated with R5% predicted and Fres while WC correlated positively with R5, R5% predicted, Ax and Fres; same way, NC with X5% predicted. Conclusion: Obesity/overweight causes significant changes in lung volumes, capacity and airway mechanics, Higher WC and WHR are associated with significant changes in lung mechanics, which are more prominent in females than in males. NC is not associated with changes in lung mechanics. |
| first_indexed | 2024-03-13T10:36:50Z |
| format | Article |
| id | doaj.art-3c11f1696d9144e69fb0512a58f5803e |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-03-13T10:36:50Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-3c11f1696d9144e69fb0512a58f5803e2023-05-18T05:47:18ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102023-01-0127216116610.4103/ijem.ijem_363_22Effect of obesity on airway mechanicsKumar ShanmugasundaramGeetanjali BadeMeghashree SampathAnjana TalwarBackground: Obesity is known to induce lung function impairment. Previous studies of decline in lung function associated with obesity are well established. Materials and Methods: In this cross-sectional study, to evaluate the effects of different obesity indices on lung mechanics, healthy subjects (males-23 and females-22) were recruited. Anthropometric parameters like body mass index (BMI), waist circumference (WC), hip circumference (HC) and neck circumference (NC) were measured and waist-hip ratio (WHR) was derived. Spirometry, impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO) measurements were performed to assess lung function. Subgroups were divided and analysed. Results: In males, increased WHR is associated with increased total airway resistance (R5). BMI correlates positively with R5, R5% predicted, resistance at 20 Hz (R20) and R20% predicted; likewise, WHR shows a positive correlation with R5. In females, increased WHR has significantly higher R5, R5% predicted, R20, R20% predicted, area of reactance (Ax), resonant frequency (Fres) and decreased reactance at 5 Hz (X5), reactance at 20 Hz (X20), X20% predicted. The female group with higher WC shows significantly increased R5, R5% predicted, R20, R20% predicted, Ax, Fres and lower fixed ratio of forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC), X5, X20, X20% predicted. The group with higher NC has a lower FEV1/FVC ratio. WHR positively correlated with R5% predicted and Fres while WC correlated positively with R5, R5% predicted, Ax and Fres; same way, NC with X5% predicted. Conclusion: Obesity/overweight causes significant changes in lung volumes, capacity and airway mechanics, Higher WC and WHR are associated with significant changes in lung mechanics, which are more prominent in females than in males. NC is not associated with changes in lung mechanics.http://www.ijem.in/article.asp?issn=2230-8210;year=2023;volume=27;issue=2;spage=161;epage=166;aulast=Shanmugasundaramgenderimpulse oscillometrylung mechanicsobesityspirometry |
| spellingShingle | Kumar Shanmugasundaram Geetanjali Bade Meghashree Sampath Anjana Talwar Effect of obesity on airway mechanics Indian Journal of Endocrinology and Metabolism gender impulse oscillometry lung mechanics obesity spirometry |
| title | Effect of obesity on airway mechanics |
| title_full | Effect of obesity on airway mechanics |
| title_fullStr | Effect of obesity on airway mechanics |
| title_full_unstemmed | Effect of obesity on airway mechanics |
| title_short | Effect of obesity on airway mechanics |
| title_sort | effect of obesity on airway mechanics |
| topic | gender impulse oscillometry lung mechanics obesity spirometry |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2023;volume=27;issue=2;spage=161;epage=166;aulast=Shanmugasundaram |
| work_keys_str_mv | AT kumarshanmugasundaram effectofobesityonairwaymechanics AT geetanjalibade effectofobesityonairwaymechanics AT meghashreesampath effectofobesityonairwaymechanics AT anjanatalwar effectofobesityonairwaymechanics |