Evaluation of Na+, K+-ATPase activity in the brain of young rats after acute administration of fenproporex
Objectives: Fenproporex is an amphetamine-based anorectic which is rapidly converted into amphetamine in vivo. Na+, K+-ATPase is a membrane-bound enzyme necessary to maintain neuronal excitability. Considering that the effects of fenproporex on brain metabolism are poorly known and that Na+, K+-ATPa...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Psiquiatria (ABP)
2014-05-01
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| Series: | Brazilian Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462014000200138&lng=en&tlng=en |
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| author | Gislaine T. Rezin Giselli Scaini Cinara L. Gonçalves Gabriela K. Ferreira Mariane R. Cardoso Andréa G.K. Ferreira Maira J. Cunha Felipe Schmitz Roger B. Varela João Quevedo Angela T.S. Wyse Emilio L. Streck |
| author_facet | Gislaine T. Rezin Giselli Scaini Cinara L. Gonçalves Gabriela K. Ferreira Mariane R. Cardoso Andréa G.K. Ferreira Maira J. Cunha Felipe Schmitz Roger B. Varela João Quevedo Angela T.S. Wyse Emilio L. Streck |
| author_sort | Gislaine T. Rezin |
| collection | DOAJ |
| description | Objectives: Fenproporex is an amphetamine-based anorectic which is rapidly converted into amphetamine in vivo. Na+, K+-ATPase is a membrane-bound enzyme necessary to maintain neuronal excitability. Considering that the effects of fenproporex on brain metabolism are poorly known and that Na+, K+-ATPase is essential for normal brain function, this study sought to evaluate the effect of this drug on Na+, K+-ATPase activity in the hippocampus, hypothalamus, prefrontal cortex, and striatum of young rats. Methods: Young male Wistar rats received a single injection of fenproporex (6.25, 12.5, or 25 mg/kg intraperitoneally) or polysorbate 80 (control group). Two hours after the last injection, the rats were killed by decapitation and the brain was removed for evaluation of Na+, K+-ATPase activity. Results: Fenproporex decreased Na+, K+-ATPase activity in the striatum of young rats at doses of 6.25, 12.5, and 25 mg/kg and increased enzyme activity in the hypothalamus at the same doses. Na+, K+-ATPase activity was not affected in the hippocampus or prefrontal cortex. Conclusion: Fenproporex administration decreased Na+, K+-ATPase activity in the striatum even in low doses. However, in the hypothalamus, Na+, K+-ATPase activity was increased. Changes in this enzyme might be the result of the effects of fenproporex on neuronal excitability. |
| first_indexed | 2024-04-11T22:48:46Z |
| format | Article |
| id | doaj.art-3c12b1d8b08445e0b6fb84067c7f66f3 |
| institution | Directory Open Access Journal |
| issn | 1809-452X |
| language | English |
| last_indexed | 2024-04-11T22:48:46Z |
| publishDate | 2014-05-01 |
| publisher | Associação Brasileira de Psiquiatria (ABP) |
| record_format | Article |
| series | Brazilian Journal of Psychiatry |
| spelling | doaj.art-3c12b1d8b08445e0b6fb84067c7f66f32022-12-22T03:58:39ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1809-452X2014-05-0136213814210.1590/1516-4446-2012-0956S1516-44462014000200138Evaluation of Na+, K+-ATPase activity in the brain of young rats after acute administration of fenproporexGislaine T. RezinGiselli ScainiCinara L. GonçalvesGabriela K. FerreiraMariane R. CardosoAndréa G.K. FerreiraMaira J. CunhaFelipe SchmitzRoger B. VarelaJoão QuevedoAngela T.S. WyseEmilio L. StreckObjectives: Fenproporex is an amphetamine-based anorectic which is rapidly converted into amphetamine in vivo. Na+, K+-ATPase is a membrane-bound enzyme necessary to maintain neuronal excitability. Considering that the effects of fenproporex on brain metabolism are poorly known and that Na+, K+-ATPase is essential for normal brain function, this study sought to evaluate the effect of this drug on Na+, K+-ATPase activity in the hippocampus, hypothalamus, prefrontal cortex, and striatum of young rats. Methods: Young male Wistar rats received a single injection of fenproporex (6.25, 12.5, or 25 mg/kg intraperitoneally) or polysorbate 80 (control group). Two hours after the last injection, the rats were killed by decapitation and the brain was removed for evaluation of Na+, K+-ATPase activity. Results: Fenproporex decreased Na+, K+-ATPase activity in the striatum of young rats at doses of 6.25, 12.5, and 25 mg/kg and increased enzyme activity in the hypothalamus at the same doses. Na+, K+-ATPase activity was not affected in the hippocampus or prefrontal cortex. Conclusion: Fenproporex administration decreased Na+, K+-ATPase activity in the striatum even in low doses. However, in the hypothalamus, Na+, K+-ATPase activity was increased. Changes in this enzyme might be the result of the effects of fenproporex on neuronal excitability.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462014000200138&lng=en&tlng=enNa+, K+-ATPase activitybrainfenproporex |
| spellingShingle | Gislaine T. Rezin Giselli Scaini Cinara L. Gonçalves Gabriela K. Ferreira Mariane R. Cardoso Andréa G.K. Ferreira Maira J. Cunha Felipe Schmitz Roger B. Varela João Quevedo Angela T.S. Wyse Emilio L. Streck Evaluation of Na+, K+-ATPase activity in the brain of young rats after acute administration of fenproporex Brazilian Journal of Psychiatry Na+, K+-ATPase activity brain fenproporex |
| title | Evaluation of Na+, K+-ATPase activity in the brain of young rats after acute administration of fenproporex |
| title_full | Evaluation of Na+, K+-ATPase activity in the brain of young rats after acute administration of fenproporex |
| title_fullStr | Evaluation of Na+, K+-ATPase activity in the brain of young rats after acute administration of fenproporex |
| title_full_unstemmed | Evaluation of Na+, K+-ATPase activity in the brain of young rats after acute administration of fenproporex |
| title_short | Evaluation of Na+, K+-ATPase activity in the brain of young rats after acute administration of fenproporex |
| title_sort | evaluation of na k atpase activity in the brain of young rats after acute administration of fenproporex |
| topic | Na+, K+-ATPase activity brain fenproporex |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462014000200138&lng=en&tlng=en |
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