Neurofibromatosis Type 2 Involving the Brain and Spinal Cord
Neurofibromatosis type 2 is a rare genetic disease that occurs with a frequency of approximately 1 in 50,000 newborns and is characterized by benign tumors, mainly bilateral schwannomas of the VIII cranial nerve. It is inherited by an autosomal dominant type without sex. Clinical symptoms are associ...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Luchevaya Diagnostika, LLC
2021-06-01
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| Series: | Вестник рентгенологии и радиологии |
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| Online Access: | https://www.russianradiology.ru/jour/article/view/629 |
| _version_ | 1797341602112339968 |
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| author | O. A. Staroseltseva N. V. Nudnov M. L. Radutnaya I. G. Shchelkunova A. A. Yakovlev A. N. Vorobyev A. N. Kirchin |
| author_facet | O. A. Staroseltseva N. V. Nudnov M. L. Radutnaya I. G. Shchelkunova A. A. Yakovlev A. N. Vorobyev A. N. Kirchin |
| author_sort | O. A. Staroseltseva |
| collection | DOAJ |
| description | Neurofibromatosis type 2 is a rare genetic disease that occurs with a frequency of approximately 1 in 50,000 newborns and is characterized by benign tumors, mainly bilateral schwannomas of the VIII cranial nerve. It is inherited by an autosomal dominant type without sex. Clinical symptoms are associated with damage to the VIII pair of cranial nerves, skin manifestations are less common than with neurofibromatosis type 1. The tumor can be one-sided and can be combined with neurofibromas, meningiomas (intracranial and spinal), schwannomas of other cranial nerves, astrocytomas and ependymomas of the spinal cord. In detecting tumors and making a primary diagnosis, the leading role is played by instrumental diagnostic methods: magnetic resonance imaging (MRI) and computed tomography (CT). The final diagnosis is made after genetic analysis. The article presents the possibilities of CT and MRI in imaging and diagnosis of type neurofibromatosis type 2. |
| first_indexed | 2024-03-08T10:21:28Z |
| format | Article |
| id | doaj.art-3c13b2df5a57477a8ac977efd0d8b31d |
| institution | Directory Open Access Journal |
| issn | 0042-4676 2619-0478 |
| language | English |
| last_indexed | 2024-03-08T10:21:28Z |
| publishDate | 2021-06-01 |
| publisher | Luchevaya Diagnostika, LLC |
| record_format | Article |
| series | Вестник рентгенологии и радиологии |
| spelling | doaj.art-3c13b2df5a57477a8ac977efd0d8b31d2024-01-27T18:38:36ZengLuchevaya Diagnostika, LLCВестник рентгенологии и радиологии0042-46762619-04782021-06-0110229810810.20862/0042-4676-2021-102-2-98-108370Neurofibromatosis Type 2 Involving the Brain and Spinal CordO. A. Staroseltseva0N. V. Nudnov1M. L. Radutnaya2I. G. Shchelkunova3A. A. Yakovlev4A. N. Vorobyev5A. N. Kirchin6Federal Scientific and Clinical Center for Resuscitation and RehabilitationRussian Scientific Center of RoentgenoradiologyFederal Scientific and Clinical Center for Resuscitation and RehabilitationFederal Scientific and Clinical Center for Resuscitation and RehabilitationFederal Scientific and Clinical Center for Resuscitation and RehabilitationFederal Scientific and Clinical Center for Resuscitation and RehabilitationFederal Scientific and Clinical Center for Resuscitation and RehabilitationNeurofibromatosis type 2 is a rare genetic disease that occurs with a frequency of approximately 1 in 50,000 newborns and is characterized by benign tumors, mainly bilateral schwannomas of the VIII cranial nerve. It is inherited by an autosomal dominant type without sex. Clinical symptoms are associated with damage to the VIII pair of cranial nerves, skin manifestations are less common than with neurofibromatosis type 1. The tumor can be one-sided and can be combined with neurofibromas, meningiomas (intracranial and spinal), schwannomas of other cranial nerves, astrocytomas and ependymomas of the spinal cord. In detecting tumors and making a primary diagnosis, the leading role is played by instrumental diagnostic methods: magnetic resonance imaging (MRI) and computed tomography (CT). The final diagnosis is made after genetic analysis. The article presents the possibilities of CT and MRI in imaging and diagnosis of type neurofibromatosis type 2.https://www.russianradiology.ru/jour/article/view/629computed tomographymagnetic resonance imagingbrainspinal cordmeningiomaschwannoma |
| spellingShingle | O. A. Staroseltseva N. V. Nudnov M. L. Radutnaya I. G. Shchelkunova A. A. Yakovlev A. N. Vorobyev A. N. Kirchin Neurofibromatosis Type 2 Involving the Brain and Spinal Cord Вестник рентгенологии и радиологии computed tomography magnetic resonance imaging brain spinal cord meningioma schwannoma |
| title | Neurofibromatosis Type 2 Involving the Brain and Spinal Cord |
| title_full | Neurofibromatosis Type 2 Involving the Brain and Spinal Cord |
| title_fullStr | Neurofibromatosis Type 2 Involving the Brain and Spinal Cord |
| title_full_unstemmed | Neurofibromatosis Type 2 Involving the Brain and Spinal Cord |
| title_short | Neurofibromatosis Type 2 Involving the Brain and Spinal Cord |
| title_sort | neurofibromatosis type 2 involving the brain and spinal cord |
| topic | computed tomography magnetic resonance imaging brain spinal cord meningioma schwannoma |
| url | https://www.russianradiology.ru/jour/article/view/629 |
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