Malaria in humait a county, state of Amazonas, Brazil. XIX - evaluation of clindamycin for the treatment of patients with Plasmodium falciparum infection
A total of 207 patients with malaria caused by Plasmodium falciparum were submitted to 5 different treatment schedules with clindamycin from 1981 to 1984: A - 89 patients were treated intravenously and orally, or intramuscularly and orally with 20 mg/kg/day divided into two daily applications for 5...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
1988-09-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821988000300005&lng=en&tlng=en |
| _version_ | 1811336746712956928 |
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| author | Domingos Alves Meira Paulo Camara Marques Pereira Jussara Marcondes-Machado Rinaido Poncio Mendes Benedito Barraviera José Antonio G. Pirola Maria Regina Cotrim Guimarães Paulo Roberto Curi Renato Pedro Rodrigues |
| author_facet | Domingos Alves Meira Paulo Camara Marques Pereira Jussara Marcondes-Machado Rinaido Poncio Mendes Benedito Barraviera José Antonio G. Pirola Maria Regina Cotrim Guimarães Paulo Roberto Curi Renato Pedro Rodrigues |
| author_sort | Domingos Alves Meira |
| collection | DOAJ |
| description | A total of 207 patients with malaria caused by Plasmodium falciparum were submitted to 5 different treatment schedules with clindamycin from 1981 to 1984: A - 89 patients were treated intravenously and orally, or intramuscularly and orally with 20 mg/kg/day divided into two daily applications for 5 to 7 days; B-40 patients were treated orally with 20 mg/kg/day divided into two daily doses for 5 to 7 days; C-27 patients were treated with 20 mg/kg/day intravenously or orally divided into two daily applications for 3 days; D-16 patients were treated orally and/or intravenously with a single daily dose of 20 to 40 mg/kg/day for 5 to 7 days; E-35 patients were treated orally with 5 mg/kg/day divided into two doses for 5 days. Patients were examined daily during treatment and reexamined on the 7th, 24th, 21st, 28th and 35th day both clinically and parasitologically (blood test). Eighty three (40.1%) had moderate or severe malaria, and 97 (46.8%) had shown resistance to chloroquine or to the combination ofsulfadoxin and pyrimethamine. The proportion of cured patients was higher than 95% among patients submitted to schedules A and B. Side effects were only occasional and of low intensity. Three deaths occurred (1.4%), two of them involving patients whose signs and symptoms were already very severe when treatment was started. Thus, clindamycin proved to be very useful in the treatment of patients with malaria caused by Plasmodium falciparum and we recommend schedule A for moderate and severe cases and Bfor initial cases. |
| first_indexed | 2024-04-13T17:44:07Z |
| format | Article |
| id | doaj.art-3c15a9b097224547a0050cde4fd2afb1 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-13T17:44:07Z |
| publishDate | 1988-09-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-3c15a9b097224547a0050cde4fd2afb12022-12-22T02:37:04ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98491988-09-0121312312910.1590/S0037-86821988000300005S0037-86821988000300005Malaria in humait a county, state of Amazonas, Brazil. XIX - evaluation of clindamycin for the treatment of patients with Plasmodium falciparum infectionDomingos Alves Meira0Paulo Camara Marques Pereira1Jussara Marcondes-Machado2Rinaido Poncio Mendes3Benedito Barraviera4José Antonio G. Pirola5Maria Regina Cotrim Guimarães6Paulo Roberto Curi7Renato Pedro Rodrigues8Faculdade de MedicinaFaculdade de MedicinaFaculdade de MedicinaFaculdade de MedicinaFaculdade de MedicinaFaculdade de MedicinaFaculdade de MedicinaFaculdade de MedicinaFaculdade de MedicinaA total of 207 patients with malaria caused by Plasmodium falciparum were submitted to 5 different treatment schedules with clindamycin from 1981 to 1984: A - 89 patients were treated intravenously and orally, or intramuscularly and orally with 20 mg/kg/day divided into two daily applications for 5 to 7 days; B-40 patients were treated orally with 20 mg/kg/day divided into two daily doses for 5 to 7 days; C-27 patients were treated with 20 mg/kg/day intravenously or orally divided into two daily applications for 3 days; D-16 patients were treated orally and/or intravenously with a single daily dose of 20 to 40 mg/kg/day for 5 to 7 days; E-35 patients were treated orally with 5 mg/kg/day divided into two doses for 5 days. Patients were examined daily during treatment and reexamined on the 7th, 24th, 21st, 28th and 35th day both clinically and parasitologically (blood test). Eighty three (40.1%) had moderate or severe malaria, and 97 (46.8%) had shown resistance to chloroquine or to the combination ofsulfadoxin and pyrimethamine. The proportion of cured patients was higher than 95% among patients submitted to schedules A and B. Side effects were only occasional and of low intensity. Three deaths occurred (1.4%), two of them involving patients whose signs and symptoms were already very severe when treatment was started. Thus, clindamycin proved to be very useful in the treatment of patients with malaria caused by Plasmodium falciparum and we recommend schedule A for moderate and severe cases and Bfor initial cases.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821988000300005&lng=en&tlng=enTratamento da maláriaPlasmodium falciparumClindamicina |
| spellingShingle | Domingos Alves Meira Paulo Camara Marques Pereira Jussara Marcondes-Machado Rinaido Poncio Mendes Benedito Barraviera José Antonio G. Pirola Maria Regina Cotrim Guimarães Paulo Roberto Curi Renato Pedro Rodrigues Malaria in humait a county, state of Amazonas, Brazil. XIX - evaluation of clindamycin for the treatment of patients with Plasmodium falciparum infection Revista da Sociedade Brasileira de Medicina Tropical Tratamento da malária Plasmodium falciparum Clindamicina |
| title | Malaria in humait a county, state of Amazonas, Brazil. XIX - evaluation of clindamycin for the treatment of patients with Plasmodium falciparum infection |
| title_full | Malaria in humait a county, state of Amazonas, Brazil. XIX - evaluation of clindamycin for the treatment of patients with Plasmodium falciparum infection |
| title_fullStr | Malaria in humait a county, state of Amazonas, Brazil. XIX - evaluation of clindamycin for the treatment of patients with Plasmodium falciparum infection |
| title_full_unstemmed | Malaria in humait a county, state of Amazonas, Brazil. XIX - evaluation of clindamycin for the treatment of patients with Plasmodium falciparum infection |
| title_short | Malaria in humait a county, state of Amazonas, Brazil. XIX - evaluation of clindamycin for the treatment of patients with Plasmodium falciparum infection |
| title_sort | malaria in humait a county state of amazonas brazil xix evaluation of clindamycin for the treatment of patients with plasmodium falciparum infection |
| topic | Tratamento da malária Plasmodium falciparum Clindamicina |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821988000300005&lng=en&tlng=en |
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