Prevalence of Musculoskeletal Post-COVID Pain in Hospitalized COVID-19 Survivors Depending on Infection with the Historical, Alpha or Delta SARS-CoV-2 Variant
We compared the prevalence of musculoskeletal post-COVID pain between previously hospitalized COVID-19 survivors infected with the historical, Alpha or Delta SARS-CoV-2 variant. Data about musculoskeletal post-COVID pain were systematically collected through a telephone interview involving 201 patie...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/8/1951 |
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| author | César Fernández-de-las-Peñas Ignacio Cancela-Cilleruelo Paloma Moro-López-Menchero Jorge Rodríguez-Jiménez Víctor Gómez-Mayordomo Juan Torres-Macho Oscar J. Pellicer-Valero José D. Martín-Guerrero Valentín Hernández-Barrera Lars Arendt-Nielsen |
| author_facet | César Fernández-de-las-Peñas Ignacio Cancela-Cilleruelo Paloma Moro-López-Menchero Jorge Rodríguez-Jiménez Víctor Gómez-Mayordomo Juan Torres-Macho Oscar J. Pellicer-Valero José D. Martín-Guerrero Valentín Hernández-Barrera Lars Arendt-Nielsen |
| author_sort | César Fernández-de-las-Peñas |
| collection | DOAJ |
| description | We compared the prevalence of musculoskeletal post-COVID pain between previously hospitalized COVID-19 survivors infected with the historical, Alpha or Delta SARS-CoV-2 variant. Data about musculoskeletal post-COVID pain were systematically collected through a telephone interview involving 201 patients who had survived the historical variant, 211 who had survived the Alpha variant and 202 who had survived the Delta variant six months after hospital discharge. Participants were recruited from non-vaccinated individuals hospitalized due to SARS-CoV-2 infection in one hospital of Madrid (Spain) during three different waves of the pandemic (historical, Alpha or Delta variant). Hospitalization and clinical data were collected from hospital medical records. In addition, anxiety/depressive levels and sleep quality were also assessed. The prevalence of musculoskeletal post-COVID pain was higher (<i>p</i> = 0.003) in patients infected with the historical variant (47.7%) than in those infected with the Alpha (38.3%) or Delta (41%) variants. A significantly (<i>p</i> = 0.002) higher proportion of individuals infected with the historical variant reported generalized pain (20.5%) when compared with those infected with the other variants. The prevalence of new-onset post-COVID musculoskeletal pain reached 80.1%, 75.2% and 79.5% of patients infected with the historical, Alpha or Delta variants, respectively. No specific risk factors for developing post-COVID pain were identified depending on the SARS-CoV-2 variant. In conclusion, this study found that musculoskeletal post-COVID pain is highly prevalent in COVID-19 survivors six months after hospital discharge, with the highest prevalence and most generalized pain symptoms in individuals infected with the historical variant. Approximately 50% developed “de novo” post-COVID musculoskeletal pain symptoms. |
| first_indexed | 2024-03-09T10:00:17Z |
| format | Article |
| id | doaj.art-3c192067cbe743f58e55b58cecd47a15 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T10:00:17Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-3c192067cbe743f58e55b58cecd47a152023-12-01T23:28:08ZengMDPI AGBiomedicines2227-90592022-08-01108195110.3390/biomedicines10081951Prevalence of Musculoskeletal Post-COVID Pain in Hospitalized COVID-19 Survivors Depending on Infection with the Historical, Alpha or Delta SARS-CoV-2 VariantCésar Fernández-de-las-Peñas0Ignacio Cancela-Cilleruelo1Paloma Moro-López-Menchero2Jorge Rodríguez-Jiménez3Víctor Gómez-Mayordomo4Juan Torres-Macho5Oscar J. Pellicer-Valero6José D. Martín-Guerrero7Valentín Hernández-Barrera8Lars Arendt-Nielsen9Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, Alcorcón, 28922 Madrid, SpainDepartment of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, Alcorcón, 28922 Madrid, SpainDepartment of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, Alcorcón, 28922 Madrid, SpainDepartment of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, Alcorcón, 28922 Madrid, SpainDepartment of Neurology, Hospital Clínico San Carlos, 28040 Madrid, SpainDepartment of Internal Medicine, Hospital Universitario Infanta Leonor-Virgen de la Torre, 28031 Madrid, SpainIntelligent Data Analysis Laboratory, Department of Electronic Engineering, ETSE (Engineering School), Universitat de València (UV), 46010 Valencia, SpainIntelligent Data Analysis Laboratory, Department of Electronic Engineering, ETSE (Engineering School), Universitat de València (UV), 46010 Valencia, SpainDepartment of Public Health, Universidad Rey Juan Carlos (URJC), 28922 Madrid, SpainCenter for Neuroplasticity and Pain (CNAP), SMI, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, 9220 Aalborg, DenmarkWe compared the prevalence of musculoskeletal post-COVID pain between previously hospitalized COVID-19 survivors infected with the historical, Alpha or Delta SARS-CoV-2 variant. Data about musculoskeletal post-COVID pain were systematically collected through a telephone interview involving 201 patients who had survived the historical variant, 211 who had survived the Alpha variant and 202 who had survived the Delta variant six months after hospital discharge. Participants were recruited from non-vaccinated individuals hospitalized due to SARS-CoV-2 infection in one hospital of Madrid (Spain) during three different waves of the pandemic (historical, Alpha or Delta variant). Hospitalization and clinical data were collected from hospital medical records. In addition, anxiety/depressive levels and sleep quality were also assessed. The prevalence of musculoskeletal post-COVID pain was higher (<i>p</i> = 0.003) in patients infected with the historical variant (47.7%) than in those infected with the Alpha (38.3%) or Delta (41%) variants. A significantly (<i>p</i> = 0.002) higher proportion of individuals infected with the historical variant reported generalized pain (20.5%) when compared with those infected with the other variants. The prevalence of new-onset post-COVID musculoskeletal pain reached 80.1%, 75.2% and 79.5% of patients infected with the historical, Alpha or Delta variants, respectively. No specific risk factors for developing post-COVID pain were identified depending on the SARS-CoV-2 variant. In conclusion, this study found that musculoskeletal post-COVID pain is highly prevalent in COVID-19 survivors six months after hospital discharge, with the highest prevalence and most generalized pain symptoms in individuals infected with the historical variant. Approximately 50% developed “de novo” post-COVID musculoskeletal pain symptoms.https://www.mdpi.com/2227-9059/10/8/1951AlphaDeltavariantsmusculoskeletal painprevalence |
| spellingShingle | César Fernández-de-las-Peñas Ignacio Cancela-Cilleruelo Paloma Moro-López-Menchero Jorge Rodríguez-Jiménez Víctor Gómez-Mayordomo Juan Torres-Macho Oscar J. Pellicer-Valero José D. Martín-Guerrero Valentín Hernández-Barrera Lars Arendt-Nielsen Prevalence of Musculoskeletal Post-COVID Pain in Hospitalized COVID-19 Survivors Depending on Infection with the Historical, Alpha or Delta SARS-CoV-2 Variant Biomedicines Alpha Delta variants musculoskeletal pain prevalence |
| title | Prevalence of Musculoskeletal Post-COVID Pain in Hospitalized COVID-19 Survivors Depending on Infection with the Historical, Alpha or Delta SARS-CoV-2 Variant |
| title_full | Prevalence of Musculoskeletal Post-COVID Pain in Hospitalized COVID-19 Survivors Depending on Infection with the Historical, Alpha or Delta SARS-CoV-2 Variant |
| title_fullStr | Prevalence of Musculoskeletal Post-COVID Pain in Hospitalized COVID-19 Survivors Depending on Infection with the Historical, Alpha or Delta SARS-CoV-2 Variant |
| title_full_unstemmed | Prevalence of Musculoskeletal Post-COVID Pain in Hospitalized COVID-19 Survivors Depending on Infection with the Historical, Alpha or Delta SARS-CoV-2 Variant |
| title_short | Prevalence of Musculoskeletal Post-COVID Pain in Hospitalized COVID-19 Survivors Depending on Infection with the Historical, Alpha or Delta SARS-CoV-2 Variant |
| title_sort | prevalence of musculoskeletal post covid pain in hospitalized covid 19 survivors depending on infection with the historical alpha or delta sars cov 2 variant |
| topic | Alpha Delta variants musculoskeletal pain prevalence |
| url | https://www.mdpi.com/2227-9059/10/8/1951 |
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