Differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adults
Abstract Despite their crucial importance for human health, there is still relatively limited knowledge on how the gut resistome changes or responds to antibiotic treatment across ages, especially in the latter case. Here, we use fecal metagenomic data from 662 Danish infants and 217 young adults to...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-44289-6 |
| _version_ | 1827399389177446400 |
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| author | Xuanji Li Asker Brejnrod Jonathan Thorsen Trine Zachariasen Urvish Trivedi Jakob Russel Gisle Alberg Vestergaard Jakob Stokholm Morten Arendt Rasmussen Søren Johannes Sørensen |
| author_facet | Xuanji Li Asker Brejnrod Jonathan Thorsen Trine Zachariasen Urvish Trivedi Jakob Russel Gisle Alberg Vestergaard Jakob Stokholm Morten Arendt Rasmussen Søren Johannes Sørensen |
| author_sort | Xuanji Li |
| collection | DOAJ |
| description | Abstract Despite their crucial importance for human health, there is still relatively limited knowledge on how the gut resistome changes or responds to antibiotic treatment across ages, especially in the latter case. Here, we use fecal metagenomic data from 662 Danish infants and 217 young adults to fill this gap. The gut resistomes are characterized by a bimodal distribution driven by E. coli composition. The typical profile of the gut resistome differs significantly between adults and infants, with the latter distinguished by higher gene and plasmid abundances. However, the predominant antibiotic resistance genes (ARGs) are the same. Antibiotic treatment reduces bacterial diversity and increased ARG and plasmid abundances in both cohorts, especially core ARGs. The effects of antibiotic treatments on the gut microbiome last longer in adults than in infants, and different antibiotics are associated with distinct impacts. Overall, this study broadens our current understanding of gut resistome dynamics and the impact of antibiotic treatment across age groups. |
| first_indexed | 2024-03-08T19:45:15Z |
| format | Article |
| id | doaj.art-3c197bce9e7548da923c51672ff9cf20 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-08T19:45:15Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3c197bce9e7548da923c51672ff9cf202023-12-24T12:22:55ZengNature PortfolioNature Communications2041-17232023-12-0114111610.1038/s41467-023-44289-6Differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adultsXuanji Li0Asker Brejnrod1Jonathan Thorsen2Trine Zachariasen3Urvish Trivedi4Jakob Russel5Gisle Alberg Vestergaard6Jakob Stokholm7Morten Arendt Rasmussen8Søren Johannes Sørensen9Department of Biology, Section of Microbiology, University of CopenhagenDepartment of Health Technology, Technical University of Denmark, Section of BioinformaticsCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of CopenhagenDepartment of Health Technology, Technical University of Denmark, Section of BioinformaticsDepartment of Biology, Section of Microbiology, University of CopenhagenDepartment of Biology, Section of Microbiology, University of CopenhagenDepartment of Health Technology, Technical University of Denmark, Section of BioinformaticsCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of CopenhagenCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of CopenhagenDepartment of Biology, Section of Microbiology, University of CopenhagenAbstract Despite their crucial importance for human health, there is still relatively limited knowledge on how the gut resistome changes or responds to antibiotic treatment across ages, especially in the latter case. Here, we use fecal metagenomic data from 662 Danish infants and 217 young adults to fill this gap. The gut resistomes are characterized by a bimodal distribution driven by E. coli composition. The typical profile of the gut resistome differs significantly between adults and infants, with the latter distinguished by higher gene and plasmid abundances. However, the predominant antibiotic resistance genes (ARGs) are the same. Antibiotic treatment reduces bacterial diversity and increased ARG and plasmid abundances in both cohorts, especially core ARGs. The effects of antibiotic treatments on the gut microbiome last longer in adults than in infants, and different antibiotics are associated with distinct impacts. Overall, this study broadens our current understanding of gut resistome dynamics and the impact of antibiotic treatment across age groups.https://doi.org/10.1038/s41467-023-44289-6 |
| spellingShingle | Xuanji Li Asker Brejnrod Jonathan Thorsen Trine Zachariasen Urvish Trivedi Jakob Russel Gisle Alberg Vestergaard Jakob Stokholm Morten Arendt Rasmussen Søren Johannes Sørensen Differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adults Nature Communications |
| title | Differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adults |
| title_full | Differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adults |
| title_fullStr | Differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adults |
| title_full_unstemmed | Differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adults |
| title_short | Differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adults |
| title_sort | differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adults |
| url | https://doi.org/10.1038/s41467-023-44289-6 |
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