Fullerene and oxidative stress
<p>Fullerene derivatives superfamily attracts a serious attention as antiviral and anticancer agents and drug delivery carriers as well. A large number of such fullerene С60 derivatives obtained to date. However, there is an obvious deficit of information about causes and mechanisms of immedia...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2014-07-01
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| Series: | Онкогематология |
| Subjects: | |
| Online Access: | http://oncohematology.abvpress.ru/index.php/ongm/article/view/71 |
| _version_ | 1827837388584386560 |
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| author | M. A. Orlova T. P. Trofimova A. P. Orlov O. A. Shatalov A. A. Svistunov Yu. K. Napolov V. P. Chekhonin |
| author_facet | M. A. Orlova T. P. Trofimova A. P. Orlov O. A. Shatalov A. A. Svistunov Yu. K. Napolov V. P. Chekhonin |
| author_sort | M. A. Orlova |
| collection | DOAJ |
| description | <p>Fullerene derivatives superfamily attracts a serious attention as antiviral and anticancer agents and drug delivery carriers as well. A large number of such fullerene С60 derivatives obtained to date. However, there is an obvious deficit of information about causes and mechanisms of immediately and long-term consequences of their effects in vivo which is a true obstacle on the way leading to their practical medical using. First, this concerns their impact on the proliferation, apoptosis and necrosis regulation. Fullerene nanoparticle functionalization type, their sizes and surface nanopathology are of great importance for further promoting of either cytoprotective or cytotoxic effects. One of the main effects of fullerenes on living systems is the reactive oxygen species (ROS) formation induction. This lecture provides a modern concept analysis regarding fullerenes effects on ROS formation and modulation of proliferation and apoptosis in normal and tumor cells.</p> |
| first_indexed | 2024-03-12T06:42:05Z |
| format | Article |
| id | doaj.art-3c19f27bf4bc4a3aa035ba1bf6a422f9 |
| institution | Directory Open Access Journal |
| issn | 1818-8346 |
| language | Russian |
| last_indexed | 2024-03-12T06:42:05Z |
| publishDate | 2014-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj.art-3c19f27bf4bc4a3aa035ba1bf6a422f92023-09-03T00:54:04ZrusABV-pressОнкогематология1818-83462014-07-0174111586Fullerene and oxidative stressM. A. Orlova0T. P. Trofimova1A. P. Orlov2O. A. Shatalov3A. A. Svistunov4Yu. K. Napolov5V. P. Chekhonin6M.V. Lomonosov Moscow State UniversityM.V. Lomonosov Moscow State UniversityN.I. Pirogov Russian National Research Medical UniversityI.M. Sechenov Moscow State Medical UniversityI.M. Sechenov Moscow State Medical UniversityI.M. Sechenov Moscow State Medical UniversityN.I. Pirogov Russian National Research Medical University<p>Fullerene derivatives superfamily attracts a serious attention as antiviral and anticancer agents and drug delivery carriers as well. A large number of such fullerene С60 derivatives obtained to date. However, there is an obvious deficit of information about causes and mechanisms of immediately and long-term consequences of their effects in vivo which is a true obstacle on the way leading to their practical medical using. First, this concerns their impact on the proliferation, apoptosis and necrosis regulation. Fullerene nanoparticle functionalization type, their sizes and surface nanopathology are of great importance for further promoting of either cytoprotective or cytotoxic effects. One of the main effects of fullerenes on living systems is the reactive oxygen species (ROS) formation induction. This lecture provides a modern concept analysis regarding fullerenes effects on ROS formation and modulation of proliferation and apoptosis in normal and tumor cells.</p>http://oncohematology.abvpress.ru/index.php/ongm/article/view/71fullerenesapoptosisoxidative stress |
| spellingShingle | M. A. Orlova T. P. Trofimova A. P. Orlov O. A. Shatalov A. A. Svistunov Yu. K. Napolov V. P. Chekhonin Fullerene and oxidative stress Онкогематология fullerenes apoptosis oxidative stress |
| title | Fullerene and oxidative stress |
| title_full | Fullerene and oxidative stress |
| title_fullStr | Fullerene and oxidative stress |
| title_full_unstemmed | Fullerene and oxidative stress |
| title_short | Fullerene and oxidative stress |
| title_sort | fullerene and oxidative stress |
| topic | fullerenes apoptosis oxidative stress |
| url | http://oncohematology.abvpress.ru/index.php/ongm/article/view/71 |
| work_keys_str_mv | AT maorlova fullereneandoxidativestress AT tptrofimova fullereneandoxidativestress AT aporlov fullereneandoxidativestress AT oashatalov fullereneandoxidativestress AT aasvistunov fullereneandoxidativestress AT yuknapolov fullereneandoxidativestress AT vpchekhonin fullereneandoxidativestress |