Emerging Insights into Liver X Receptor α in the Tumorigenesis and Therapeutics of Human Cancers
Liver X receptor α (LXRα), a member of the nuclear receptor superfamily, is identified as a protein activated by ligands that interacts with the promoters of specific genes. It regulates cholesterol, bile acid, and lipid metabolism in normal physiological processes, and it participates in the develo...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/13/8/1184 |
| _version_ | 1797585376688209920 |
|---|---|
| author | Ning Han Man Yuan Libo Yan Hong Tang |
| author_facet | Ning Han Man Yuan Libo Yan Hong Tang |
| author_sort | Ning Han |
| collection | DOAJ |
| description | Liver X receptor α (LXRα), a member of the nuclear receptor superfamily, is identified as a protein activated by ligands that interacts with the promoters of specific genes. It regulates cholesterol, bile acid, and lipid metabolism in normal physiological processes, and it participates in the development of some related diseases. However, many studies have demonstrated that LXRα is also involved in regulating numerous human malignancies. Aberrant LXRα expression is emerging as a fundamental and pivotal factor in cancer cell proliferation, invasion, apoptosis, and metastasis. Herein, we outline the expression levels of LXRα between tumor tissues and normal tissues via the Oncomine and Tumor Immune Estimation Resource (TIMER) 2.0 databases; summarize emerging insights into the roles of LXRα in the development, progression, and treatment of different human cancers and their diversified mechanisms; and highlight that LXRα can be a biomarker and therapeutic target in diverse cancers. |
| first_indexed | 2024-03-11T00:05:15Z |
| format | Article |
| id | doaj.art-3c1b0133b9cd498e97fcbbe1d7511039 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T00:05:15Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-3c1b0133b9cd498e97fcbbe1d75110392023-11-19T00:23:24ZengMDPI AGBiomolecules2218-273X2023-07-01138118410.3390/biom13081184Emerging Insights into Liver X Receptor α in the Tumorigenesis and Therapeutics of Human CancersNing Han0Man Yuan1Libo Yan2Hong Tang3Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, ChinaCenter of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, ChinaCenter of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, ChinaCenter of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, ChinaLiver X receptor α (LXRα), a member of the nuclear receptor superfamily, is identified as a protein activated by ligands that interacts with the promoters of specific genes. It regulates cholesterol, bile acid, and lipid metabolism in normal physiological processes, and it participates in the development of some related diseases. However, many studies have demonstrated that LXRα is also involved in regulating numerous human malignancies. Aberrant LXRα expression is emerging as a fundamental and pivotal factor in cancer cell proliferation, invasion, apoptosis, and metastasis. Herein, we outline the expression levels of LXRα between tumor tissues and normal tissues via the Oncomine and Tumor Immune Estimation Resource (TIMER) 2.0 databases; summarize emerging insights into the roles of LXRα in the development, progression, and treatment of different human cancers and their diversified mechanisms; and highlight that LXRα can be a biomarker and therapeutic target in diverse cancers.https://www.mdpi.com/2218-273X/13/8/1184liver X receptor αtumorigenesistherapycancer |
| spellingShingle | Ning Han Man Yuan Libo Yan Hong Tang Emerging Insights into Liver X Receptor α in the Tumorigenesis and Therapeutics of Human Cancers Biomolecules liver X receptor α tumorigenesis therapy cancer |
| title | Emerging Insights into Liver X Receptor α in the Tumorigenesis and Therapeutics of Human Cancers |
| title_full | Emerging Insights into Liver X Receptor α in the Tumorigenesis and Therapeutics of Human Cancers |
| title_fullStr | Emerging Insights into Liver X Receptor α in the Tumorigenesis and Therapeutics of Human Cancers |
| title_full_unstemmed | Emerging Insights into Liver X Receptor α in the Tumorigenesis and Therapeutics of Human Cancers |
| title_short | Emerging Insights into Liver X Receptor α in the Tumorigenesis and Therapeutics of Human Cancers |
| title_sort | emerging insights into liver x receptor α in the tumorigenesis and therapeutics of human cancers |
| topic | liver X receptor α tumorigenesis therapy cancer |
| url | https://www.mdpi.com/2218-273X/13/8/1184 |
| work_keys_str_mv | AT ninghan emerginginsightsintoliverxreceptorainthetumorigenesisandtherapeuticsofhumancancers AT manyuan emerginginsightsintoliverxreceptorainthetumorigenesisandtherapeuticsofhumancancers AT liboyan emerginginsightsintoliverxreceptorainthetumorigenesisandtherapeuticsofhumancancers AT hongtang emerginginsightsintoliverxreceptorainthetumorigenesisandtherapeuticsofhumancancers |