Identification of bone-specific alkaline phosphatase in saliva and its correlation with skeletal age
Context: Bone-specific alkaline phosphatase (B-ALP), a product of osteoblasts, is a bone formation marker whose serum levels fluctuate with puberty and adolescence. Aims: This study aims to assess B-ALP levels in saliva and correlate it with different skeletal maturity stages of hand-wrist radiograp...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2018-01-01
|
| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | http://www.ijdr.in/article.asp?issn=0970-9290;year=2018;volume=29;issue=6;spage=721;epage=725;aulast=Hegde |
| _version_ | 1818583802479378432 |
|---|---|
| author | Sandesh Santoshkumar Hegde Ameet Vaman Revankar Anand Kantappa Patil |
| author_facet | Sandesh Santoshkumar Hegde Ameet Vaman Revankar Anand Kantappa Patil |
| author_sort | Sandesh Santoshkumar Hegde |
| collection | DOAJ |
| description | Context: Bone-specific alkaline phosphatase (B-ALP), a product of osteoblasts, is a bone formation marker whose serum levels fluctuate with puberty and adolescence. Aims: This study aims to assess B-ALP levels in saliva and correlate it with different skeletal maturity stages of hand-wrist radiographs using Hagg and Taranger method. Settings and Design: Observational study and cross-sectional design. Subjects and Methods: Total sample comprised of 90 individuals, right hand-wrist radiographs, and 2 ml unstimulated whole saliva samples taken from each patient on the same day. The hand-wrist radiographs were traced and staged into 5 subgroups (18 individuals each) according to Hagg and Taranger method. Statistical Analysis Used: One-way analysis of variance (ANOVA) and Tukey's multiple post hoc test. Results: The comparison of salivary B-ALP values between the different skeletal subgroups using one-way ANOVA depicted statistically significant results (P = 0.0003). Pairwise comparison using Tukey's multiple post hoc procedures showed that salivary B-ALP levels were comparatively higher in subgroup 3 and that the difference between subgroups 1 and 3 (P = 0.0109) and subgroups 3 and 5 (P = 0.0014) was statistically significant. Conclusion: B-ALP could be successfully identified and quantitatively estimated in saliva and showed significant correlation with different skeletal age subgroups as determined by Hagg and Taranger method. |
| first_indexed | 2024-12-16T08:11:04Z |
| format | Article |
| id | doaj.art-3c1e291f880242898ad01510654ec2cb |
| institution | Directory Open Access Journal |
| issn | 0970-9290 1998-3603 |
| language | English |
| last_indexed | 2024-12-16T08:11:04Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Research |
| spelling | doaj.art-3c1e291f880242898ad01510654ec2cb2022-12-21T22:38:20ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032018-01-0129672172510.4103/ijdr.IJDR_298_15Identification of bone-specific alkaline phosphatase in saliva and its correlation with skeletal ageSandesh Santoshkumar HegdeAmeet Vaman RevankarAnand Kantappa PatilContext: Bone-specific alkaline phosphatase (B-ALP), a product of osteoblasts, is a bone formation marker whose serum levels fluctuate with puberty and adolescence. Aims: This study aims to assess B-ALP levels in saliva and correlate it with different skeletal maturity stages of hand-wrist radiographs using Hagg and Taranger method. Settings and Design: Observational study and cross-sectional design. Subjects and Methods: Total sample comprised of 90 individuals, right hand-wrist radiographs, and 2 ml unstimulated whole saliva samples taken from each patient on the same day. The hand-wrist radiographs were traced and staged into 5 subgroups (18 individuals each) according to Hagg and Taranger method. Statistical Analysis Used: One-way analysis of variance (ANOVA) and Tukey's multiple post hoc test. Results: The comparison of salivary B-ALP values between the different skeletal subgroups using one-way ANOVA depicted statistically significant results (P = 0.0003). Pairwise comparison using Tukey's multiple post hoc procedures showed that salivary B-ALP levels were comparatively higher in subgroup 3 and that the difference between subgroups 1 and 3 (P = 0.0109) and subgroups 3 and 5 (P = 0.0014) was statistically significant. Conclusion: B-ALP could be successfully identified and quantitatively estimated in saliva and showed significant correlation with different skeletal age subgroups as determined by Hagg and Taranger method.http://www.ijdr.in/article.asp?issn=0970-9290;year=2018;volume=29;issue=6;spage=721;epage=725;aulast=HegdeBone-specific alkaline phosphatasepubertysalivaskeletal ageskeletal maturity |
| spellingShingle | Sandesh Santoshkumar Hegde Ameet Vaman Revankar Anand Kantappa Patil Identification of bone-specific alkaline phosphatase in saliva and its correlation with skeletal age Indian Journal of Dental Research Bone-specific alkaline phosphatase puberty saliva skeletal age skeletal maturity |
| title | Identification of bone-specific alkaline phosphatase in saliva and its correlation with skeletal age |
| title_full | Identification of bone-specific alkaline phosphatase in saliva and its correlation with skeletal age |
| title_fullStr | Identification of bone-specific alkaline phosphatase in saliva and its correlation with skeletal age |
| title_full_unstemmed | Identification of bone-specific alkaline phosphatase in saliva and its correlation with skeletal age |
| title_short | Identification of bone-specific alkaline phosphatase in saliva and its correlation with skeletal age |
| title_sort | identification of bone specific alkaline phosphatase in saliva and its correlation with skeletal age |
| topic | Bone-specific alkaline phosphatase puberty saliva skeletal age skeletal maturity |
| url | http://www.ijdr.in/article.asp?issn=0970-9290;year=2018;volume=29;issue=6;spage=721;epage=725;aulast=Hegde |
| work_keys_str_mv | AT sandeshsantoshkumarhegde identificationofbonespecificalkalinephosphataseinsalivaanditscorrelationwithskeletalage AT ameetvamanrevankar identificationofbonespecificalkalinephosphataseinsalivaanditscorrelationwithskeletalage AT anandkantappapatil identificationofbonespecificalkalinephosphataseinsalivaanditscorrelationwithskeletalage |