Caspase-1-driven neutrophil pyroptosis and its role in host susceptibility to Pseudomonas aeruginosa.

Caspase-1-driven neutrophil pyroptosis and its role in host susceptibility to Pseudomonas aeruginosa.

Multiple regulated neutrophil cell death programs contribute to host defense against infections. However, despite expressing all necessary inflammasome components, neutrophils are thought to be generally defective in Caspase-1-dependent pyroptosis. By screening different bacterial species, we found...

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Bibliographic Details
Main Authors: Karin Santoni, David Pericat, Leana Gorse, Julien Buyck, Miriam Pinilla, Laure Prouvensier, Salimata Bagayoko, Audrey Hessel, Stephen Adonai Leon-Icaza, Elisabeth Bellard, Serge Mazères, Emilie Doz-Deblauwe, Nathalie Winter, Christophe Paget, Jean-Philippe Girard, Christine T N Pham, Céline Cougoule, Renaud Poincloux, Mohamed Lamkanfi, Emma Lefrançais, Etienne Meunier, Rémi Planès
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010305

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