Changes in oxidative stress intensity in blood of tumor-bearing rats following different modes of administration of rhenium-platinum system
Effects of the different modes of administration of dichlorotetra-μ-isobutyratodirhenium(ІІІ) – І – (in water solution, liposomes, nanoliposomes and together with cisplatin – in the rhenium-platinum system) on the intensity of lipid peroxidation (LP) in blood plasma and the activity of the erythrocy...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2016-08-01
|
| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2016/09/Shamelashvili_4_16.pdf |
| _version_ | 1797427412185645056 |
|---|---|
| author | K. L. Shamelashvili N. I. Shtemenko І. V. Leus S. O. Babiy O. V. Shtemenko |
| author_facet | K. L. Shamelashvili N. I. Shtemenko І. V. Leus S. O. Babiy O. V. Shtemenko |
| author_sort | K. L. Shamelashvili |
| collection | DOAJ |
| description | Effects of the different modes of administration of dichlorotetra-μ-isobutyratodirhenium(ІІІ) – І – (in water solution, liposomes, nanoliposomes and together with cisplatin – in the rhenium-platinum system) on the intensity of lipid peroxidation (LP) in blood plasma and the activity of the erythrocyte antioxidant enzymes were investigated on the model of tumor growth. A decrease in the concentration of TBA-active substances caused by dirhenium compounds was shown to be independent of the administration mode and the extent of the tumor growth inhibition. I was four-times more effective in inhibition of the LP burst than any known antioxidant. I induced the increasing activity of erythrocyte superoxide dismutase and decreasing activity of catalase. In vitro experiments with native superoxide dismutase, the interaction of І with following activation of the active center of the enzyme was confirmed and the superoxide dismutase activity of І was shown, that may contribute to the enhancement of the enzyme activity in vivo. The cluster rhenium compounds may be promising nontoxic potent antioxidants capable of deactivating superoxide radicals. |
| first_indexed | 2024-03-09T08:44:44Z |
| format | Article |
| id | doaj.art-3c1ed3a81da04438920abea440a378a0 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-09T08:44:44Z |
| publishDate | 2016-08-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-3c1ed3a81da04438920abea440a378a02023-12-02T15:44:17ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032016-08-01884293910.15407/ubj88.04.029Changes in oxidative stress intensity in blood of tumor-bearing rats following different modes of administration of rhenium-platinum systemK. L. Shamelashvili0 N. I. Shtemenko1 І. V. Leus2 S. O. Babiy3O. V. Shtemenko4SE “Dnipropetrovsk Medical Academy” of Health Ministry of UkrainePalladin Institute of Biochemistry, National Academy of Sciences of Ukraine, KyivUniversity of Oklahoma, Oklahoma-city, USAInstitute of Gastroenterology, National Academy of Medical Sciences of Ukraine, DnipropetrovskInstitute of Gastroenterology, National Academy of Medical Sciences of Ukraine, DnipropetrovskEffects of the different modes of administration of dichlorotetra-μ-isobutyratodirhenium(ІІІ) – І – (in water solution, liposomes, nanoliposomes and together with cisplatin – in the rhenium-platinum system) on the intensity of lipid peroxidation (LP) in blood plasma and the activity of the erythrocyte antioxidant enzymes were investigated on the model of tumor growth. A decrease in the concentration of TBA-active substances caused by dirhenium compounds was shown to be independent of the administration mode and the extent of the tumor growth inhibition. I was four-times more effective in inhibition of the LP burst than any known antioxidant. I induced the increasing activity of erythrocyte superoxide dismutase and decreasing activity of catalase. In vitro experiments with native superoxide dismutase, the interaction of І with following activation of the active center of the enzyme was confirmed and the superoxide dismutase activity of І was shown, that may contribute to the enhancement of the enzyme activity in vivo. The cluster rhenium compounds may be promising nontoxic potent antioxidants capable of deactivating superoxide radicals.http://ukrbiochemjournal.org/wp-content/uploads/2016/09/Shamelashvili_4_16.pdfcisplatincatalaseGuerin’s carcinoma |
| spellingShingle | K. L. Shamelashvili N. I. Shtemenko І. V. Leus S. O. Babiy O. V. Shtemenko Changes in oxidative stress intensity in blood of tumor-bearing rats following different modes of administration of rhenium-platinum system The Ukrainian Biochemical Journal cisplatin catalase Guerin’s carcinoma |
| title | Changes in oxidative stress intensity in blood of tumor-bearing rats following different modes of administration of rhenium-platinum system |
| title_full | Changes in oxidative stress intensity in blood of tumor-bearing rats following different modes of administration of rhenium-platinum system |
| title_fullStr | Changes in oxidative stress intensity in blood of tumor-bearing rats following different modes of administration of rhenium-platinum system |
| title_full_unstemmed | Changes in oxidative stress intensity in blood of tumor-bearing rats following different modes of administration of rhenium-platinum system |
| title_short | Changes in oxidative stress intensity in blood of tumor-bearing rats following different modes of administration of rhenium-platinum system |
| title_sort | changes in oxidative stress intensity in blood of tumor bearing rats following different modes of administration of rhenium platinum system |
| topic | cisplatin catalase Guerin’s carcinoma |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2016/09/Shamelashvili_4_16.pdf |
| work_keys_str_mv | AT klshamelashvili changesinoxidativestressintensityinbloodoftumorbearingratsfollowingdifferentmodesofadministrationofrheniumplatinumsystem AT nishtemenko changesinoxidativestressintensityinbloodoftumorbearingratsfollowingdifferentmodesofadministrationofrheniumplatinumsystem AT ívleus changesinoxidativestressintensityinbloodoftumorbearingratsfollowingdifferentmodesofadministrationofrheniumplatinumsystem AT sobabiy changesinoxidativestressintensityinbloodoftumorbearingratsfollowingdifferentmodesofadministrationofrheniumplatinumsystem AT ovshtemenko changesinoxidativestressintensityinbloodoftumorbearingratsfollowingdifferentmodesofadministrationofrheniumplatinumsystem |