Arabinoxylan-Based Microcapsules Being Loaded with Bee Products as Bioactive Food Components Are Able to Modulate the Cell Migration and Inflammatory Response—In Vitro Study
The aim of the research was to use bioactive heteropolysaccharides isolated from rye bran to obtain innovative systems for the controlled release of bioactive compounds. The core of the obtained encapsulates was honey and royal jelly. It was shown for the first time that preparations effectively ame...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/12/2529 |
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| author | Gabriela Kowalska Justyna Rosicka-Kaczmarek Karolina Miśkiewicz Małgorzata Zakłos-Szyda Sascha Rohn Clemens Kanzler Magdalena Wiktorska Jolanta Niewiarowska |
| author_facet | Gabriela Kowalska Justyna Rosicka-Kaczmarek Karolina Miśkiewicz Małgorzata Zakłos-Szyda Sascha Rohn Clemens Kanzler Magdalena Wiktorska Jolanta Niewiarowska |
| author_sort | Gabriela Kowalska |
| collection | DOAJ |
| description | The aim of the research was to use bioactive heteropolysaccharides isolated from rye bran to obtain innovative systems for the controlled release of bioactive compounds. The core of the obtained encapsulates was honey and royal jelly. It was shown for the first time that preparations effectively ameliorated inflammatory response in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages, decreasing the secretion of interleukin 6 (IL-6), tumor necrosis factor α (TNF-α) and nitric oxide (NO). The in vitro digestion process revealed that bee products’ encapsulates were stronger oxidative stress reducers and had sustained ability to reduction in inflammation state mediators. The lack of inhibitory effect on migration rate of human microvascular endothelial cells (HMEC-1) endothelial cells and mouse embryonic fibroblasts (NIH-3T3), both cell models involved in wound healing process, additionally identified these preparations as agents potentially used in the management of inflammatory response. In the process of a simulated digestion in vitro, the innovative microcapsules showed 85% higher biostability and two to ten times better bioavailability, compared to natural bee products. |
| first_indexed | 2024-03-09T22:49:14Z |
| format | Article |
| id | doaj.art-3c1ee9e1cf144734be373e9676897a9b |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T22:49:14Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3c1ee9e1cf144734be373e9676897a9b2023-11-23T18:22:44ZengMDPI AGNutrients2072-66432022-06-011412252910.3390/nu14122529Arabinoxylan-Based Microcapsules Being Loaded with Bee Products as Bioactive Food Components Are Able to Modulate the Cell Migration and Inflammatory Response—In Vitro StudyGabriela Kowalska0Justyna Rosicka-Kaczmarek1Karolina Miśkiewicz2Małgorzata Zakłos-Szyda3Sascha Rohn4Clemens Kanzler5Magdalena Wiktorska6Jolanta Niewiarowska7Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 90-537 Lodz, PolandInstitute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 90-537 Lodz, PolandInstitute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 90-537 Lodz, PolandInstitute of Molecular and Industrial Biotechnology, Lodz University of Technology, 90-537 Lodz, PolandDepartment of Food Chemistry and Analysis, Institute of Food Technology and Food Chemistry, Technische Universität Berlin, 13355 Berlin, GermanyDepartment of Food Chemistry and Analysis, Institute of Food Technology and Food Chemistry, Technische Universität Berlin, 13355 Berlin, GermanyDepartment of Molecular Cell Mechanisms, Medical University of Lodz, 92-215 Lodz, PolandDepartment of Molecular Cell Mechanisms, Medical University of Lodz, 92-215 Lodz, PolandThe aim of the research was to use bioactive heteropolysaccharides isolated from rye bran to obtain innovative systems for the controlled release of bioactive compounds. The core of the obtained encapsulates was honey and royal jelly. It was shown for the first time that preparations effectively ameliorated inflammatory response in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages, decreasing the secretion of interleukin 6 (IL-6), tumor necrosis factor α (TNF-α) and nitric oxide (NO). The in vitro digestion process revealed that bee products’ encapsulates were stronger oxidative stress reducers and had sustained ability to reduction in inflammation state mediators. The lack of inhibitory effect on migration rate of human microvascular endothelial cells (HMEC-1) endothelial cells and mouse embryonic fibroblasts (NIH-3T3), both cell models involved in wound healing process, additionally identified these preparations as agents potentially used in the management of inflammatory response. In the process of a simulated digestion in vitro, the innovative microcapsules showed 85% higher biostability and two to ten times better bioavailability, compared to natural bee products.https://www.mdpi.com/2072-6643/14/12/2529rye branbioactive heteropolysaccharidesarabinoxylans-based microcapsulesbee productsbiostabilityinflammatory response |
| spellingShingle | Gabriela Kowalska Justyna Rosicka-Kaczmarek Karolina Miśkiewicz Małgorzata Zakłos-Szyda Sascha Rohn Clemens Kanzler Magdalena Wiktorska Jolanta Niewiarowska Arabinoxylan-Based Microcapsules Being Loaded with Bee Products as Bioactive Food Components Are Able to Modulate the Cell Migration and Inflammatory Response—In Vitro Study Nutrients rye bran bioactive heteropolysaccharides arabinoxylans-based microcapsules bee products biostability inflammatory response |
| title | Arabinoxylan-Based Microcapsules Being Loaded with Bee Products as Bioactive Food Components Are Able to Modulate the Cell Migration and Inflammatory Response—In Vitro Study |
| title_full | Arabinoxylan-Based Microcapsules Being Loaded with Bee Products as Bioactive Food Components Are Able to Modulate the Cell Migration and Inflammatory Response—In Vitro Study |
| title_fullStr | Arabinoxylan-Based Microcapsules Being Loaded with Bee Products as Bioactive Food Components Are Able to Modulate the Cell Migration and Inflammatory Response—In Vitro Study |
| title_full_unstemmed | Arabinoxylan-Based Microcapsules Being Loaded with Bee Products as Bioactive Food Components Are Able to Modulate the Cell Migration and Inflammatory Response—In Vitro Study |
| title_short | Arabinoxylan-Based Microcapsules Being Loaded with Bee Products as Bioactive Food Components Are Able to Modulate the Cell Migration and Inflammatory Response—In Vitro Study |
| title_sort | arabinoxylan based microcapsules being loaded with bee products as bioactive food components are able to modulate the cell migration and inflammatory response in vitro study |
| topic | rye bran bioactive heteropolysaccharides arabinoxylans-based microcapsules bee products biostability inflammatory response |
| url | https://www.mdpi.com/2072-6643/14/12/2529 |
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