Uji Aktivitas Sitotoksik dan Antibakteri Ekstrak Daun Tumbuhan Rengas (Gluta renghas L)
Generally, Gluta renghas L. is known because of its very toxic latex which can cause hard irritations to skin. Although, rengas latex has efficacy as an antibacterial agent. Related to previous research, it has been reported that there are urisol, rengol, glutarengol, laccol, and thitsiol in rengas...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas
2020-03-01
|
| Series: | Jurnal Riset Kimia |
| Subjects: | |
| Online Access: | http://jrk.fmipa.unand.ac.id/index.php/jrk/article/view/345 |
| _version_ | 1818856827199160320 |
|---|---|
| author | Sanusi Ibrahim Suryati Suryati Enda Desriansyah Aziz |
| author_facet | Sanusi Ibrahim Suryati Suryati Enda Desriansyah Aziz |
| author_sort | Sanusi Ibrahim |
| collection | DOAJ |
| description | Generally, Gluta renghas L. is known because of its very toxic latex which can cause hard irritations to skin. Although, rengas latex has efficacy as an antibacterial agent. Related to previous research, it has been reported that there are urisol, rengol, glutarengol, laccol, and thitsiol in rengas latex. The woody trunk was reported to contain flavonoid, benzenoid, lipid, and steroid compounds. The leaves, were reported shows that the leaves of G. renghas contain an anticholinesterase substance and can be reduced the rate of hydrolysis of acetylcholine. Extraction of rengas leaves has been carried out. It has been shown phenols, steroids, and coumarins compounds in methanol extract, flavonoids, phenols, saponins and alkaloids compounds in ethyl acetate extract, steroids and alkaloids compounds in hexane extract. In the present, cytotoxicity and antibacterial activity have been tested. The results show that the great cytotoxicity activity by ethyl acetate extracts which have an LC50 value is 123,718 µg/mL (R2 0.9822), while the great antibacterial activity shown by methanol extract 1,000 µg/mL with a diameter of inhibition zone 19.02 mm (S. aureus) and 16.06 mm (E. coli). |
| first_indexed | 2024-12-19T08:30:41Z |
| format | Article |
| id | doaj.art-3c21152bd2f54f528859764e53a21ab3 |
| institution | Directory Open Access Journal |
| issn | 1978-628X 2476-8960 |
| language | English |
| last_indexed | 2024-12-19T08:30:41Z |
| publishDate | 2020-03-01 |
| publisher | Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas |
| record_format | Article |
| series | Jurnal Riset Kimia |
| spelling | doaj.art-3c21152bd2f54f528859764e53a21ab32022-12-21T20:29:12ZengDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas AndalasJurnal Riset Kimia1978-628X2476-89602020-03-01111526010.25077/jrk.v11i1.345217Uji Aktivitas Sitotoksik dan Antibakteri Ekstrak Daun Tumbuhan Rengas (Gluta renghas L)Sanusi Ibrahim0Suryati Suryati1Enda Desriansyah Aziz2Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas, Padang 25163, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas, Padang 25163, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas, Padang 25163, IndonesiaGenerally, Gluta renghas L. is known because of its very toxic latex which can cause hard irritations to skin. Although, rengas latex has efficacy as an antibacterial agent. Related to previous research, it has been reported that there are urisol, rengol, glutarengol, laccol, and thitsiol in rengas latex. The woody trunk was reported to contain flavonoid, benzenoid, lipid, and steroid compounds. The leaves, were reported shows that the leaves of G. renghas contain an anticholinesterase substance and can be reduced the rate of hydrolysis of acetylcholine. Extraction of rengas leaves has been carried out. It has been shown phenols, steroids, and coumarins compounds in methanol extract, flavonoids, phenols, saponins and alkaloids compounds in ethyl acetate extract, steroids and alkaloids compounds in hexane extract. In the present, cytotoxicity and antibacterial activity have been tested. The results show that the great cytotoxicity activity by ethyl acetate extracts which have an LC50 value is 123,718 µg/mL (R2 0.9822), while the great antibacterial activity shown by methanol extract 1,000 µg/mL with a diameter of inhibition zone 19.02 mm (S. aureus) and 16.06 mm (E. coli).http://jrk.fmipa.unand.ac.id/index.php/jrk/article/view/345gluta renghas lsecondary metabolitescytotoxicantibacterial |
| spellingShingle | Sanusi Ibrahim Suryati Suryati Enda Desriansyah Aziz Uji Aktivitas Sitotoksik dan Antibakteri Ekstrak Daun Tumbuhan Rengas (Gluta renghas L) Jurnal Riset Kimia gluta renghas l secondary metabolites cytotoxic antibacterial |
| title | Uji Aktivitas Sitotoksik dan Antibakteri Ekstrak Daun Tumbuhan Rengas (Gluta renghas L) |
| title_full | Uji Aktivitas Sitotoksik dan Antibakteri Ekstrak Daun Tumbuhan Rengas (Gluta renghas L) |
| title_fullStr | Uji Aktivitas Sitotoksik dan Antibakteri Ekstrak Daun Tumbuhan Rengas (Gluta renghas L) |
| title_full_unstemmed | Uji Aktivitas Sitotoksik dan Antibakteri Ekstrak Daun Tumbuhan Rengas (Gluta renghas L) |
| title_short | Uji Aktivitas Sitotoksik dan Antibakteri Ekstrak Daun Tumbuhan Rengas (Gluta renghas L) |
| title_sort | uji aktivitas sitotoksik dan antibakteri ekstrak daun tumbuhan rengas gluta renghas l |
| topic | gluta renghas l secondary metabolites cytotoxic antibacterial |
| url | http://jrk.fmipa.unand.ac.id/index.php/jrk/article/view/345 |
| work_keys_str_mv | AT sanusiibrahim ujiaktivitassitotoksikdanantibakteriekstrakdauntumbuhanrengasglutarenghasl AT suryatisuryati ujiaktivitassitotoksikdanantibakteriekstrakdauntumbuhanrengasglutarenghasl AT endadesriansyahaziz ujiaktivitassitotoksikdanantibakteriekstrakdauntumbuhanrengasglutarenghasl |