Meningococcal Vaccines: Current Status and Emerging Strategies
Neisseria meningitidis causes most cases of bacterial meningitis. Meningococcal meningitis is a public health burden to both developed and developing countries throughout the world. There are a number of vaccines (polysaccharide-based, glycoconjugate, protein-based and combined conjugate vaccines) t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-02-01
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| Series: | Vaccines |
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| Online Access: | http://www.mdpi.com/2076-393X/6/1/12 |
| _version_ | 1811306672707076096 |
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| author | Pumtiwitt C. McCarthy Abeer Sharyan Laleh Sheikhi Moghaddam |
| author_facet | Pumtiwitt C. McCarthy Abeer Sharyan Laleh Sheikhi Moghaddam |
| author_sort | Pumtiwitt C. McCarthy |
| collection | DOAJ |
| description | Neisseria meningitidis causes most cases of bacterial meningitis. Meningococcal meningitis is a public health burden to both developed and developing countries throughout the world. There are a number of vaccines (polysaccharide-based, glycoconjugate, protein-based and combined conjugate vaccines) that are approved to target five of the six disease-causing serogroups of the pathogen. Immunization strategies have been effective at helping to decrease the global incidence of meningococcal meningitis. Researchers continue to enhance these efforts through discovery of new antigen targets that may lead to a broadly protective vaccine and development of new methods of homogenous vaccine production. This review describes current meningococcal vaccines and discusses some recent research discoveries that may transform vaccine development against N. meningitidis in the future. |
| first_indexed | 2024-04-13T08:49:41Z |
| format | Article |
| id | doaj.art-3c213ab51946441cb2ea19a43f2b2cd3 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-04-13T08:49:41Z |
| publishDate | 2018-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-3c213ab51946441cb2ea19a43f2b2cd32022-12-22T02:53:31ZengMDPI AGVaccines2076-393X2018-02-01611210.3390/vaccines6010012vaccines6010012Meningococcal Vaccines: Current Status and Emerging StrategiesPumtiwitt C. McCarthy0Abeer Sharyan1Laleh Sheikhi Moghaddam2Department of Chemistry, Morgan State University, Baltimore, MD 21251, USADepartment of Chemistry, Morgan State University, Baltimore, MD 21251, USADepartment of Chemistry, Morgan State University, Baltimore, MD 21251, USANeisseria meningitidis causes most cases of bacterial meningitis. Meningococcal meningitis is a public health burden to both developed and developing countries throughout the world. There are a number of vaccines (polysaccharide-based, glycoconjugate, protein-based and combined conjugate vaccines) that are approved to target five of the six disease-causing serogroups of the pathogen. Immunization strategies have been effective at helping to decrease the global incidence of meningococcal meningitis. Researchers continue to enhance these efforts through discovery of new antigen targets that may lead to a broadly protective vaccine and development of new methods of homogenous vaccine production. This review describes current meningococcal vaccines and discusses some recent research discoveries that may transform vaccine development against N. meningitidis in the future.http://www.mdpi.com/2076-393X/6/1/12Neisseria meningitidisglycoconjugate vaccinesprotein-based vaccinesvaccine development |
| spellingShingle | Pumtiwitt C. McCarthy Abeer Sharyan Laleh Sheikhi Moghaddam Meningococcal Vaccines: Current Status and Emerging Strategies Vaccines Neisseria meningitidis glycoconjugate vaccines protein-based vaccines vaccine development |
| title | Meningococcal Vaccines: Current Status and Emerging Strategies |
| title_full | Meningococcal Vaccines: Current Status and Emerging Strategies |
| title_fullStr | Meningococcal Vaccines: Current Status and Emerging Strategies |
| title_full_unstemmed | Meningococcal Vaccines: Current Status and Emerging Strategies |
| title_short | Meningococcal Vaccines: Current Status and Emerging Strategies |
| title_sort | meningococcal vaccines current status and emerging strategies |
| topic | Neisseria meningitidis glycoconjugate vaccines protein-based vaccines vaccine development |
| url | http://www.mdpi.com/2076-393X/6/1/12 |
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