Physical and autonomic functionality in women with breast cancer pre and post chemotherapy: a case control study
Abstract Background Breast cancer (BC) is one of the most incident types of cancer among women in the world. Although chemotherapy is an effective way to treat several types of cancer, it may also cause serious complications, including cardiotoxicity. This study aimed to identify the impact of chemo...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Sports Science, Medicine and Rehabilitation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13102-023-00797-y |
| _version_ | 1797362989199785984 |
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| author | Bruna Lorena Soares Cavalcante Sousa Thiago dos Santos Rosa Valmir Oliveira Silvino Esmeralda Maria Lustosa Barros Hugo de Luca Corrêa Danilo Marcelo Leite do Prado Acácio Salvador Veras-Silva Mariana Duarte de Souza Carlos Eduardo Batista de Lima Luciano Fonseca Lemos de Oliveira Marcos Antonio Pereira dos Santos |
| author_facet | Bruna Lorena Soares Cavalcante Sousa Thiago dos Santos Rosa Valmir Oliveira Silvino Esmeralda Maria Lustosa Barros Hugo de Luca Corrêa Danilo Marcelo Leite do Prado Acácio Salvador Veras-Silva Mariana Duarte de Souza Carlos Eduardo Batista de Lima Luciano Fonseca Lemos de Oliveira Marcos Antonio Pereira dos Santos |
| author_sort | Bruna Lorena Soares Cavalcante Sousa |
| collection | DOAJ |
| description | Abstract Background Breast cancer (BC) is one of the most incident types of cancer among women in the world. Although chemotherapy is an effective way to treat several types of cancer, it may also cause serious complications, including cardiotoxicity. This study aimed to identify the impact of chemotherapy on functional capacity, muscle strength and autonomic function. Methods Ten breast cancer patients in therapeutic follow-up (TG) and ten women without comorbidities (CG) participated in the study (46±8.87 years old). Both groups were evaluated at two time points, before and 20 weeks after the start of chemotherapy. Functional capacity and muscle strength were assessed by 6-minute walk test (6MWT) and handgrip test, respectively. Autonomic function was assessed by heart rate variability analysis. Results TG presented greater reductions in the handgrip test for the non-dominant hand (TG ↓15.2%; CG: ↑1.1%, p<0.05) compared to GC. However, no significant differences were found regarding VO2max (p>0.05) and 6MWT total distance (p>0.05). Regarding the heart rate variability variables before and after follow-up period, rMSSD (CG= 39.15±37.66; TG= 14.89±8.28, p= 0.01) and SDNN (CG= 55.77±40.03; TG= 26.30±10.37, p= 0.02) showed effect in the group and time interaction, whereas the LF/HF ratio presented significant difference only in the time analysis (CG= 2.24±2.30; TG= 2.84±1.82, p= 0.04). Conclusion Chemotherapy used in the treatment of breast cancer patients resulted in decreased muscle strength and autonomic imbalance. The data suggests that chemotherapy may carry the risk of developing cardiovascular disease. Trial registration Registration not required. |
| first_indexed | 2024-03-08T16:15:07Z |
| format | Article |
| id | doaj.art-3c23aa325abf45e38f5d68fcd37e4631 |
| institution | Directory Open Access Journal |
| issn | 2052-1847 |
| language | English |
| last_indexed | 2024-03-08T16:15:07Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Sports Science, Medicine and Rehabilitation |
| spelling | doaj.art-3c23aa325abf45e38f5d68fcd37e46312024-01-07T12:38:44ZengBMCBMC Sports Science, Medicine and Rehabilitation2052-18472024-01-0116111010.1186/s13102-023-00797-yPhysical and autonomic functionality in women with breast cancer pre and post chemotherapy: a case control studyBruna Lorena Soares Cavalcante Sousa0Thiago dos Santos Rosa1Valmir Oliveira Silvino2Esmeralda Maria Lustosa Barros3Hugo de Luca Corrêa4Danilo Marcelo Leite do Prado5Acácio Salvador Veras-Silva6Mariana Duarte de Souza7Carlos Eduardo Batista de Lima8Luciano Fonseca Lemos de Oliveira9Marcos Antonio Pereira dos Santos10Nucleus of Study in Physiology Applied to Performance and Health (NEFADS), Federal University of PiauiDepartment of Physical Education, Catholic University of BrasiliaNucleus of Study in Physiology Applied to Performance and Health (NEFADS), Federal University of PiauiNucleus of Study in Physiology Applied to Performance and Health (NEFADS), Federal University of PiauiDepartment of Physical Education, Catholic University of BrasiliaUniversity of São Paulo, School of MedicineDepartment of Biophysics and Physiology, Federal University of PiauiRehabilitation Sciences Program, Federal University of Minas GeraisClinical Research Center of the University Hospital, Federal University of Piaui, Empresa Brasileira de Serviços Hospitalares (EBSERH)Department of Applied Physical Therapy, Federal University of Triangulo MineiroNucleus of Study in Physiology Applied to Performance and Health (NEFADS), Federal University of PiauiAbstract Background Breast cancer (BC) is one of the most incident types of cancer among women in the world. Although chemotherapy is an effective way to treat several types of cancer, it may also cause serious complications, including cardiotoxicity. This study aimed to identify the impact of chemotherapy on functional capacity, muscle strength and autonomic function. Methods Ten breast cancer patients in therapeutic follow-up (TG) and ten women without comorbidities (CG) participated in the study (46±8.87 years old). Both groups were evaluated at two time points, before and 20 weeks after the start of chemotherapy. Functional capacity and muscle strength were assessed by 6-minute walk test (6MWT) and handgrip test, respectively. Autonomic function was assessed by heart rate variability analysis. Results TG presented greater reductions in the handgrip test for the non-dominant hand (TG ↓15.2%; CG: ↑1.1%, p<0.05) compared to GC. However, no significant differences were found regarding VO2max (p>0.05) and 6MWT total distance (p>0.05). Regarding the heart rate variability variables before and after follow-up period, rMSSD (CG= 39.15±37.66; TG= 14.89±8.28, p= 0.01) and SDNN (CG= 55.77±40.03; TG= 26.30±10.37, p= 0.02) showed effect in the group and time interaction, whereas the LF/HF ratio presented significant difference only in the time analysis (CG= 2.24±2.30; TG= 2.84±1.82, p= 0.04). Conclusion Chemotherapy used in the treatment of breast cancer patients resulted in decreased muscle strength and autonomic imbalance. The data suggests that chemotherapy may carry the risk of developing cardiovascular disease. Trial registration Registration not required.https://doi.org/10.1186/s13102-023-00797-yCardiotoxicityPhysical functional performanceExercise testBreast neoplasms |
| spellingShingle | Bruna Lorena Soares Cavalcante Sousa Thiago dos Santos Rosa Valmir Oliveira Silvino Esmeralda Maria Lustosa Barros Hugo de Luca Corrêa Danilo Marcelo Leite do Prado Acácio Salvador Veras-Silva Mariana Duarte de Souza Carlos Eduardo Batista de Lima Luciano Fonseca Lemos de Oliveira Marcos Antonio Pereira dos Santos Physical and autonomic functionality in women with breast cancer pre and post chemotherapy: a case control study BMC Sports Science, Medicine and Rehabilitation Cardiotoxicity Physical functional performance Exercise test Breast neoplasms |
| title | Physical and autonomic functionality in women with breast cancer pre and post chemotherapy: a case control study |
| title_full | Physical and autonomic functionality in women with breast cancer pre and post chemotherapy: a case control study |
| title_fullStr | Physical and autonomic functionality in women with breast cancer pre and post chemotherapy: a case control study |
| title_full_unstemmed | Physical and autonomic functionality in women with breast cancer pre and post chemotherapy: a case control study |
| title_short | Physical and autonomic functionality in women with breast cancer pre and post chemotherapy: a case control study |
| title_sort | physical and autonomic functionality in women with breast cancer pre and post chemotherapy a case control study |
| topic | Cardiotoxicity Physical functional performance Exercise test Breast neoplasms |
| url | https://doi.org/10.1186/s13102-023-00797-y |
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