Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling
The cell cycle is the series of events that take place in a cell, which drives it to divide and produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the following phases: G1, S, G2, and M phase. Cell cycle progression is mediated by cyclin-dependent kinases (Cdks) and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/12/3327 |
| _version_ | 1797505946461667328 |
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| author | Zhixiang Wang |
| author_facet | Zhixiang Wang |
| author_sort | Zhixiang Wang |
| collection | DOAJ |
| description | The cell cycle is the series of events that take place in a cell, which drives it to divide and produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the following phases: G1, S, G2, and M phase. Cell cycle progression is mediated by cyclin-dependent kinases (Cdks) and their regulatory cyclin subunits. However, the driving force of cell cycle progression is growth factor-initiated signaling pathways that control the activity of various Cdk–cyclin complexes. While the mechanism underlying the role of growth factor signaling in G1 phase of cell cycle progression has been largely revealed due to early extensive research, little is known regarding the function and mechanism of growth factor signaling in regulating other phases of the cell cycle, including S, G2, and M phase. In this review, we briefly discuss the process of cell cycle progression through various phases, and we focus on the role of signaling pathways activated by growth factors and their receptor (mostly receptor tyrosine kinases) in regulating cell cycle progression through various phases. |
| first_indexed | 2024-03-10T04:25:36Z |
| format | Article |
| id | doaj.art-3c24d8c7249c4235b0ec2f63f3a5ab55 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T04:25:36Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-3c24d8c7249c4235b0ec2f63f3a5ab552023-11-23T07:36:16ZengMDPI AGCells2073-44092021-11-011012332710.3390/cells10123327Regulation of Cell Cycle Progression by Growth Factor-Induced Cell SignalingZhixiang Wang0Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G2H7, CanadaThe cell cycle is the series of events that take place in a cell, which drives it to divide and produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the following phases: G1, S, G2, and M phase. Cell cycle progression is mediated by cyclin-dependent kinases (Cdks) and their regulatory cyclin subunits. However, the driving force of cell cycle progression is growth factor-initiated signaling pathways that control the activity of various Cdk–cyclin complexes. While the mechanism underlying the role of growth factor signaling in G1 phase of cell cycle progression has been largely revealed due to early extensive research, little is known regarding the function and mechanism of growth factor signaling in regulating other phases of the cell cycle, including S, G2, and M phase. In this review, we briefly discuss the process of cell cycle progression through various phases, and we focus on the role of signaling pathways activated by growth factors and their receptor (mostly receptor tyrosine kinases) in regulating cell cycle progression through various phases.https://www.mdpi.com/2073-4409/10/12/3327cell cyclegrowth factorsreceptor tyrosine kinasesG1 phaseS phaseG2 phase |
| spellingShingle | Zhixiang Wang Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling Cells cell cycle growth factors receptor tyrosine kinases G1 phase S phase G2 phase |
| title | Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling |
| title_full | Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling |
| title_fullStr | Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling |
| title_full_unstemmed | Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling |
| title_short | Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling |
| title_sort | regulation of cell cycle progression by growth factor induced cell signaling |
| topic | cell cycle growth factors receptor tyrosine kinases G1 phase S phase G2 phase |
| url | https://www.mdpi.com/2073-4409/10/12/3327 |
| work_keys_str_mv | AT zhixiangwang regulationofcellcycleprogressionbygrowthfactorinducedcellsignaling |