Role of small RNAs in trypanosomatid infections
Trypanosomatid parasites survive and replicate in the host by using mechanisms that aim to establish a successful infection and ensure parasite survival. Evidence points to microRNAs as new players in the host-parasite interplay. MicroRNAs are small noncoding RNAs that control proteins levels via po...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-03-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00367/full |
| _version_ | 1818684796811870208 |
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| author | Leandra eLinhares-Lacerda Alexandre eMorrot |
| author_facet | Leandra eLinhares-Lacerda Alexandre eMorrot |
| author_sort | Leandra eLinhares-Lacerda |
| collection | DOAJ |
| description | Trypanosomatid parasites survive and replicate in the host by using mechanisms that aim to establish a successful infection and ensure parasite survival. Evidence points to microRNAs as new players in the host-parasite interplay. MicroRNAs are small noncoding RNAs that control proteins levels via post-transcriptional gene down-regulation, either within the cells where they were produced or in other cells via intercellular transfer. These microRNAs can be modulated in host cells during infection and are among the growing group of small regulatory RNAs, for which many classes have been described, including the transfer RNA-derived small RNAs. Parasites can either manipulate microRNAs to evade host-driven damage and/or transfer small RNAs to host cells. In this mini-review, we present evidence for the involvement of small RNAs, such as microRNAs, in trypanosomatid infections which lack RNA interference. We highlight both microRNA profile alterations in host cells during those infections and the horizontal transfer of small RNAs and proteins from parasites to the host by membrane-derived extracellular vesicles in a cell communication mechanism. |
| first_indexed | 2024-12-17T10:56:20Z |
| format | Article |
| id | doaj.art-3c26e40e5df4402c9915d3f1cb804ed0 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-17T10:56:20Z |
| publishDate | 2016-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-3c26e40e5df4402c9915d3f1cb804ed02022-12-21T21:51:48ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2016-03-01710.3389/fmicb.2016.00367173987Role of small RNAs in trypanosomatid infectionsLeandra eLinhares-Lacerda0Alexandre eMorrot1Oswaldo Cruz FoundationFederal University of Rio de JaneiroTrypanosomatid parasites survive and replicate in the host by using mechanisms that aim to establish a successful infection and ensure parasite survival. Evidence points to microRNAs as new players in the host-parasite interplay. MicroRNAs are small noncoding RNAs that control proteins levels via post-transcriptional gene down-regulation, either within the cells where they were produced or in other cells via intercellular transfer. These microRNAs can be modulated in host cells during infection and are among the growing group of small regulatory RNAs, for which many classes have been described, including the transfer RNA-derived small RNAs. Parasites can either manipulate microRNAs to evade host-driven damage and/or transfer small RNAs to host cells. In this mini-review, we present evidence for the involvement of small RNAs, such as microRNAs, in trypanosomatid infections which lack RNA interference. We highlight both microRNA profile alterations in host cells during those infections and the horizontal transfer of small RNAs and proteins from parasites to the host by membrane-derived extracellular vesicles in a cell communication mechanism.http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00367/fullCell Communicationhost-parasite interactionsmall RNAsextracellular vesiclesmicroRNAs (miRNAs)trypanosomatid infections |
| spellingShingle | Leandra eLinhares-Lacerda Alexandre eMorrot Role of small RNAs in trypanosomatid infections Frontiers in Microbiology Cell Communication host-parasite interaction small RNAs extracellular vesicles microRNAs (miRNAs) trypanosomatid infections |
| title | Role of small RNAs in trypanosomatid infections |
| title_full | Role of small RNAs in trypanosomatid infections |
| title_fullStr | Role of small RNAs in trypanosomatid infections |
| title_full_unstemmed | Role of small RNAs in trypanosomatid infections |
| title_short | Role of small RNAs in trypanosomatid infections |
| title_sort | role of small rnas in trypanosomatid infections |
| topic | Cell Communication host-parasite interaction small RNAs extracellular vesicles microRNAs (miRNAs) trypanosomatid infections |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00367/full |
| work_keys_str_mv | AT leandraelinhareslacerda roleofsmallrnasintrypanosomatidinfections AT alexandreemorrot roleofsmallrnasintrypanosomatidinfections |