Loss of In Vivo Replication Fitness of HIV-1 Variants Resistant to the Tat Inhibitor, dCA

Loss of In Vivo Replication Fitness of HIV-1 Variants Resistant to the Tat Inhibitor, dCA

HIV resistance to the Tat inhibitor didehydro-cortistatin A (dCA) in vitro correlates with higher levels of Tat-independent viral transcription and a seeming inability to enter latency, which rendered resistant isolates more susceptible to CTL-mediated immune clearance. Here, we investigated the abi...

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Bibliographic Details
Main Authors: Lijun Ling, Ana R. Leda, Nurjahan Begum, Rae Ann Spagnuolo, Angela Wahl, J. Victor Garcia, Susana T. Valente
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Viruses
Subjects:
HIV-1
Tat inhibitor
resistance
latency promoting agent
transcription
dCA
Online Access:https://www.mdpi.com/1999-4915/15/4/950

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