The correlation between HLA class II and β-thalassemia major in Al-Karama teaching hospital
Background: Thalassemia is a form of inherited autosomal recessive blood disorder characterized by abnormal formation of hemoglobin. Objective: Determine frequencies & association of HLA class II alleles (DRB1& DQB1) in Iraqi β-thalassemia major patients. Patients: seventy unrelated randomly...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2016-01-01
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| Series: | مجلة كلية الطب |
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| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/287 |
| _version_ | 1797370066668355584 |
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| author | Sarmad M. Zeiny |
| author_facet | Sarmad M. Zeiny |
| author_sort | Sarmad M. Zeiny |
| collection | DOAJ |
| description | Background: Thalassemia is a form of inherited autosomal recessive blood disorder characterized by abnormal formation of hemoglobin.
Objective: Determine frequencies & association of HLA class II alleles (DRB1& DQB1) in Iraqi β-thalassemia major patients.
Patients: seventy unrelated randomly selected β-thalassemia major patients, and one hundred unrelated randomly selected healthy individuals, composed the control group.
Methods: low resolution PCR-SSO (Sequence Specific Oligonucleotide) technique was used for HLA typing.
Results: HLA DQB1*5 give significance importance as an etiological risk factor for β-thalassemia major; HLA DQB1*3 give significance importance as a preventive risk factor for β-thalassemia major.
Conclusion: The positive association of HLA DQB1*5 and DQB1*3 with β-thalassemia major may have the possibility that these antigens, or the genes encoding them, are closely linked with other possible susceptibility genes. |
| first_indexed | 2024-03-08T17:56:01Z |
| format | Article |
| id | doaj.art-3c2a02e9d45042debf89f1b0e9f70179 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:56:01Z |
| publishDate | 2016-01-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-3c2a02e9d45042debf89f1b0e9f701792024-01-02T04:43:28ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572016-01-0158410.32007/jfacmedbagdad.v4366-370%The correlation between HLA class II and β-thalassemia major in Al-Karama teaching hospitalSarmad M. Zeiny0Dept. of microbiology, college of medicine, University of Baghdad.Background: Thalassemia is a form of inherited autosomal recessive blood disorder characterized by abnormal formation of hemoglobin. Objective: Determine frequencies & association of HLA class II alleles (DRB1& DQB1) in Iraqi β-thalassemia major patients. Patients: seventy unrelated randomly selected β-thalassemia major patients, and one hundred unrelated randomly selected healthy individuals, composed the control group. Methods: low resolution PCR-SSO (Sequence Specific Oligonucleotide) technique was used for HLA typing. Results: HLA DQB1*5 give significance importance as an etiological risk factor for β-thalassemia major; HLA DQB1*3 give significance importance as a preventive risk factor for β-thalassemia major. Conclusion: The positive association of HLA DQB1*5 and DQB1*3 with β-thalassemia major may have the possibility that these antigens, or the genes encoding them, are closely linked with other possible susceptibility genes.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/287β-thalassemia major, PCR-SSO, HLA class II. |
| spellingShingle | Sarmad M. Zeiny The correlation between HLA class II and β-thalassemia major in Al-Karama teaching hospital مجلة كلية الطب β-thalassemia major, PCR-SSO, HLA class II. |
| title | The correlation between HLA class II and β-thalassemia major in Al-Karama teaching hospital |
| title_full | The correlation between HLA class II and β-thalassemia major in Al-Karama teaching hospital |
| title_fullStr | The correlation between HLA class II and β-thalassemia major in Al-Karama teaching hospital |
| title_full_unstemmed | The correlation between HLA class II and β-thalassemia major in Al-Karama teaching hospital |
| title_short | The correlation between HLA class II and β-thalassemia major in Al-Karama teaching hospital |
| title_sort | correlation between hla class ii and β thalassemia major in al karama teaching hospital |
| topic | β-thalassemia major, PCR-SSO, HLA class II. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/287 |
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