Interactions of natural polyamines with mammalian proteins
The ubiquitously expressed natural polyamines putrescine, spermidine, and spermine are small, flexible cationic compounds that exert pleiotropic actions on various regulatory systems and, accordingly, are essentially involved in diverse life functions. These roles of polyamines result from their cap...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2011-04-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc.2011.007 |
| _version_ | 1818729470585995264 |
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| author | Schuster Inge Bernhardt Rita |
| author_facet | Schuster Inge Bernhardt Rita |
| author_sort | Schuster Inge |
| collection | DOAJ |
| description | The ubiquitously expressed natural polyamines putrescine, spermidine, and spermine are small, flexible cationic compounds that exert pleiotropic actions on various regulatory systems and, accordingly, are essentially involved in diverse life functions. These roles of polyamines result from their capability to interact with negatively charged regions of all major classes of biomolecules, which might act in response by changing their structures and functions. The present review deals with polyamine-protein interactions, thereby focusing on mammalian proteins. We discuss the various modes in which polyamines can interact with proteins, describe major types of affected functions illustrated by representative examples of involved proteins, and support information with respective structural evidence from elucidated three-dimensional structures. A specific focus is put on polyamine interactions at protein surfaces that can modulate the aggregation of proteins to organized structural networks as well as to toxic aggregates and, moreover, can play a role in important transient protein-protein interactions. |
| first_indexed | 2024-12-17T22:46:24Z |
| format | Article |
| id | doaj.art-3c2a24ee42b7450da9de7ba80988a424 |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-17T22:46:24Z |
| publishDate | 2011-04-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-3c2a24ee42b7450da9de7ba80988a4242022-12-21T21:29:47ZengDe GruyterBiomolecular Concepts1868-50211868-503X2011-04-0121-2799410.1515/bmc.2011.007Interactions of natural polyamines with mammalian proteinsSchuster Inge0Bernhardt Rita1Institute for Theoretical Chemistry, University Vienna, A-1090 Vienna, AustriaInstitute of Biochemistry, Saarland University, Campus B2.2, D-66123 Saarbrücken, GermanyThe ubiquitously expressed natural polyamines putrescine, spermidine, and spermine are small, flexible cationic compounds that exert pleiotropic actions on various regulatory systems and, accordingly, are essentially involved in diverse life functions. These roles of polyamines result from their capability to interact with negatively charged regions of all major classes of biomolecules, which might act in response by changing their structures and functions. The present review deals with polyamine-protein interactions, thereby focusing on mammalian proteins. We discuss the various modes in which polyamines can interact with proteins, describe major types of affected functions illustrated by representative examples of involved proteins, and support information with respective structural evidence from elucidated three-dimensional structures. A specific focus is put on polyamine interactions at protein surfaces that can modulate the aggregation of proteins to organized structural networks as well as to toxic aggregates and, moreover, can play a role in important transient protein-protein interactions.https://doi.org/10.1515/bmc.2011.007aggregationcytochrome p450ion channelspolyaminesprotein kinasesprotein-protein interactionsredox chains |
| spellingShingle | Schuster Inge Bernhardt Rita Interactions of natural polyamines with mammalian proteins Biomolecular Concepts aggregation cytochrome p450 ion channels polyamines protein kinases protein-protein interactions redox chains |
| title | Interactions of natural polyamines with mammalian proteins |
| title_full | Interactions of natural polyamines with mammalian proteins |
| title_fullStr | Interactions of natural polyamines with mammalian proteins |
| title_full_unstemmed | Interactions of natural polyamines with mammalian proteins |
| title_short | Interactions of natural polyamines with mammalian proteins |
| title_sort | interactions of natural polyamines with mammalian proteins |
| topic | aggregation cytochrome p450 ion channels polyamines protein kinases protein-protein interactions redox chains |
| url | https://doi.org/10.1515/bmc.2011.007 |
| work_keys_str_mv | AT schusteringe interactionsofnaturalpolyamineswithmammalianproteins AT bernhardtrita interactionsofnaturalpolyamineswithmammalianproteins |