Non-small cell lung cancer in never smokers: a clinical entity to be identified
OBJECTIVES: It has been recognized that patients with non-small cell lung cancer who are lifelong never-smokers constitute a distinct clinical entity. The aim of this study was to assess clinical risk factors for survival among neversmokers with non-small cell lung cancer. METHODS: All consecutive n...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2011-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011001100005 |
| _version_ | 1818254918201376768 |
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| author | Ilka Lopes Santoro Roberta Pulcheri Ramos Juliana Franceschini Sergio Jamnik Ana Luisa Godoy Fernandes |
| author_facet | Ilka Lopes Santoro Roberta Pulcheri Ramos Juliana Franceschini Sergio Jamnik Ana Luisa Godoy Fernandes |
| author_sort | Ilka Lopes Santoro |
| collection | DOAJ |
| description | OBJECTIVES: It has been recognized that patients with non-small cell lung cancer who are lifelong never-smokers constitute a distinct clinical entity. The aim of this study was to assess clinical risk factors for survival among neversmokers with non-small cell lung cancer. METHODS: All consecutive non-small cell lung cancer patients diagnosed (n = 285) between May 2005 and May 2009 were included. The clinical characteristics of never-smokers and ever-smokers (former and current) were compared using chi-squared or Student's t tests. Survival curves were calculated using the Kaplan-Meier method, and log-rank tests were used for survival comparisons. A Cox proportional hazards regression analysis was evaluated by adjusting for age (continuous variable), gender (female vs. male), smoking status (never- vs. ever-smoker), the Karnofsky Performance Status Scale (continuous variable), histological type (adenocarcinoma vs. non-adenocarcinoma), AJCC staging (early vs. advanced staging), and treatment (chemotherapy and/or radiotherapy vs. the best treatment support). RESULTS: Of the 285 non-small cell lung cancer patients, 56 patients were never-smokers. Univariate analyses indicated that the never-smoker patients were more likely to be female (68% vs. 32%) and have adenocarcinoma (70% vs. 51%). Overall median survival was 15.7 months (95% CI: 13.2 to 18.2). The never-smoker patients had a better survival rate than their counterpart, the ever-smokers. Never-smoker status, higher Karnofsky Performance Status, early staging, and treatment were independent and favorable prognostic factors for survival after adjusting for age, gender, and adenocarcinoma in multivariate analysis. CONCLUSIONS: Epidemiological differences exist between never- and ever-smokers with lung cancer. Overall survival among never-smokers was found to be higher and independent of gender and histological type. |
| first_indexed | 2024-12-12T17:03:36Z |
| format | Article |
| id | doaj.art-3c2ce0f60ba24ceeb263d9c97a51cf76 |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-12-12T17:03:36Z |
| publishDate | 2011-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-3c2ce0f60ba24ceeb263d9c97a51cf762022-12-22T00:18:04ZengElsevier EspañaClinics1807-59321980-53222011-01-0166111873187710.1590/S1807-59322011001100005Non-small cell lung cancer in never smokers: a clinical entity to be identifiedIlka Lopes SantoroRoberta Pulcheri RamosJuliana FranceschiniSergio JamnikAna Luisa Godoy FernandesOBJECTIVES: It has been recognized that patients with non-small cell lung cancer who are lifelong never-smokers constitute a distinct clinical entity. The aim of this study was to assess clinical risk factors for survival among neversmokers with non-small cell lung cancer. METHODS: All consecutive non-small cell lung cancer patients diagnosed (n = 285) between May 2005 and May 2009 were included. The clinical characteristics of never-smokers and ever-smokers (former and current) were compared using chi-squared or Student's t tests. Survival curves were calculated using the Kaplan-Meier method, and log-rank tests were used for survival comparisons. A Cox proportional hazards regression analysis was evaluated by adjusting for age (continuous variable), gender (female vs. male), smoking status (never- vs. ever-smoker), the Karnofsky Performance Status Scale (continuous variable), histological type (adenocarcinoma vs. non-adenocarcinoma), AJCC staging (early vs. advanced staging), and treatment (chemotherapy and/or radiotherapy vs. the best treatment support). RESULTS: Of the 285 non-small cell lung cancer patients, 56 patients were never-smokers. Univariate analyses indicated that the never-smoker patients were more likely to be female (68% vs. 32%) and have adenocarcinoma (70% vs. 51%). Overall median survival was 15.7 months (95% CI: 13.2 to 18.2). The never-smoker patients had a better survival rate than their counterpart, the ever-smokers. Never-smoker status, higher Karnofsky Performance Status, early staging, and treatment were independent and favorable prognostic factors for survival after adjusting for age, gender, and adenocarcinoma in multivariate analysis. CONCLUSIONS: Epidemiological differences exist between never- and ever-smokers with lung cancer. Overall survival among never-smokers was found to be higher and independent of gender and histological type.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011001100005Lung neoplasmNon-small cell lung cancerAdenocarcinomaNever-smokerSmoking |
| spellingShingle | Ilka Lopes Santoro Roberta Pulcheri Ramos Juliana Franceschini Sergio Jamnik Ana Luisa Godoy Fernandes Non-small cell lung cancer in never smokers: a clinical entity to be identified Clinics Lung neoplasm Non-small cell lung cancer Adenocarcinoma Never-smoker Smoking |
| title | Non-small cell lung cancer in never smokers: a clinical entity to be identified |
| title_full | Non-small cell lung cancer in never smokers: a clinical entity to be identified |
| title_fullStr | Non-small cell lung cancer in never smokers: a clinical entity to be identified |
| title_full_unstemmed | Non-small cell lung cancer in never smokers: a clinical entity to be identified |
| title_short | Non-small cell lung cancer in never smokers: a clinical entity to be identified |
| title_sort | non small cell lung cancer in never smokers a clinical entity to be identified |
| topic | Lung neoplasm Non-small cell lung cancer Adenocarcinoma Never-smoker Smoking |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011001100005 |
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