PCSK6 VNTR Polymorphism Is Associated with Degree of Handedness but Not Direction of Handedness.
Although the left and right human cerebral hemispheres differ both functionally and anatomically, the mechanisms that underlie the establishment of these hemispheric specializations, as well as their physiological and behavioral implications, remain largely unknown. Since cerebral asymmetry is stron...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3695088?pdf=render |
| _version_ | 1818460512191512576 |
|---|---|
| author | Larissa Arning Sebastian Ocklenburg Stefanie Schulz Vanessa Ness Wanda M Gerding Jan G Hengstler Michael Falkenstein Jörg T Epplen Onur Güntürkün Christian Beste |
| author_facet | Larissa Arning Sebastian Ocklenburg Stefanie Schulz Vanessa Ness Wanda M Gerding Jan G Hengstler Michael Falkenstein Jörg T Epplen Onur Güntürkün Christian Beste |
| author_sort | Larissa Arning |
| collection | DOAJ |
| description | Although the left and right human cerebral hemispheres differ both functionally and anatomically, the mechanisms that underlie the establishment of these hemispheric specializations, as well as their physiological and behavioral implications, remain largely unknown. Since cerebral asymmetry is strongly correlated with handedness, and handedness is assumed to be influenced by a number of genetic and environmental factors, we performed an association study of LRRTM1 rs6733871 and a number of polymorphisms in PCSK6 and different aspects of handedness assessed with the Edinburgh handedness inventory in a sample of unrelated healthy adults (n = 1113). An intronic 33bp variable-number tandem repeat (VNTR) polymorphism in PCSK6 (rs10523972) shows a significant association (significance threshold: p<0.0025, adjusted for multiple comparisons) with a handedness category comparison (P = 0.0005) and degree of handedness (P = 0.001). These results provide further evidence for the role of PCSK6 as candidate for involvement in the biological mechanisms that underlie the establishment of normal brain lateralization and thus handedness and support the assumption that the degree of handedness, instead the direction, may be the more appropriate indicator of cerebral organization. |
| first_indexed | 2024-12-14T23:31:25Z |
| format | Article |
| id | doaj.art-3c2ee1d0374f45358030062f3711206b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T23:31:25Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3c2ee1d0374f45358030062f3711206b2022-12-21T22:43:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0186e6725110.1371/journal.pone.0067251PCSK6 VNTR Polymorphism Is Associated with Degree of Handedness but Not Direction of Handedness.Larissa ArningSebastian OcklenburgStefanie SchulzVanessa NessWanda M GerdingJan G HengstlerMichael FalkensteinJörg T EpplenOnur GüntürkünChristian BesteAlthough the left and right human cerebral hemispheres differ both functionally and anatomically, the mechanisms that underlie the establishment of these hemispheric specializations, as well as their physiological and behavioral implications, remain largely unknown. Since cerebral asymmetry is strongly correlated with handedness, and handedness is assumed to be influenced by a number of genetic and environmental factors, we performed an association study of LRRTM1 rs6733871 and a number of polymorphisms in PCSK6 and different aspects of handedness assessed with the Edinburgh handedness inventory in a sample of unrelated healthy adults (n = 1113). An intronic 33bp variable-number tandem repeat (VNTR) polymorphism in PCSK6 (rs10523972) shows a significant association (significance threshold: p<0.0025, adjusted for multiple comparisons) with a handedness category comparison (P = 0.0005) and degree of handedness (P = 0.001). These results provide further evidence for the role of PCSK6 as candidate for involvement in the biological mechanisms that underlie the establishment of normal brain lateralization and thus handedness and support the assumption that the degree of handedness, instead the direction, may be the more appropriate indicator of cerebral organization.http://europepmc.org/articles/PMC3695088?pdf=render |
| spellingShingle | Larissa Arning Sebastian Ocklenburg Stefanie Schulz Vanessa Ness Wanda M Gerding Jan G Hengstler Michael Falkenstein Jörg T Epplen Onur Güntürkün Christian Beste PCSK6 VNTR Polymorphism Is Associated with Degree of Handedness but Not Direction of Handedness. PLoS ONE |
| title | PCSK6 VNTR Polymorphism Is Associated with Degree of Handedness but Not Direction of Handedness. |
| title_full | PCSK6 VNTR Polymorphism Is Associated with Degree of Handedness but Not Direction of Handedness. |
| title_fullStr | PCSK6 VNTR Polymorphism Is Associated with Degree of Handedness but Not Direction of Handedness. |
| title_full_unstemmed | PCSK6 VNTR Polymorphism Is Associated with Degree of Handedness but Not Direction of Handedness. |
| title_short | PCSK6 VNTR Polymorphism Is Associated with Degree of Handedness but Not Direction of Handedness. |
| title_sort | pcsk6 vntr polymorphism is associated with degree of handedness but not direction of handedness |
| url | http://europepmc.org/articles/PMC3695088?pdf=render |
| work_keys_str_mv | AT larissaarning pcsk6vntrpolymorphismisassociatedwithdegreeofhandednessbutnotdirectionofhandedness AT sebastianocklenburg pcsk6vntrpolymorphismisassociatedwithdegreeofhandednessbutnotdirectionofhandedness AT stefanieschulz pcsk6vntrpolymorphismisassociatedwithdegreeofhandednessbutnotdirectionofhandedness AT vanessaness pcsk6vntrpolymorphismisassociatedwithdegreeofhandednessbutnotdirectionofhandedness AT wandamgerding pcsk6vntrpolymorphismisassociatedwithdegreeofhandednessbutnotdirectionofhandedness AT janghengstler pcsk6vntrpolymorphismisassociatedwithdegreeofhandednessbutnotdirectionofhandedness AT michaelfalkenstein pcsk6vntrpolymorphismisassociatedwithdegreeofhandednessbutnotdirectionofhandedness AT jorgtepplen pcsk6vntrpolymorphismisassociatedwithdegreeofhandednessbutnotdirectionofhandedness AT onurgunturkun pcsk6vntrpolymorphismisassociatedwithdegreeofhandednessbutnotdirectionofhandedness AT christianbeste pcsk6vntrpolymorphismisassociatedwithdegreeofhandednessbutnotdirectionofhandedness |