Serotonin and dopamine modulate aging in response to food odor and availability

This report finds that dietary restriction, the most extensively studied anti-aging intervention, can be mimicked by blocking food odour signaling and identifies a neural network of food perception that functions through serotonin and dopamine.

Bibliographic Details
Main Authors: Hillary A. Miller, Shijiao Huang, Elizabeth S. Dean, Megan L. Schaller, Angela M. Tuckowski, Allyson S. Munneke, Safa Beydoun, Scott D. Pletcher, Scott F. Leiser
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30869-5
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author Hillary A. Miller
Shijiao Huang
Elizabeth S. Dean
Megan L. Schaller
Angela M. Tuckowski
Allyson S. Munneke
Safa Beydoun
Scott D. Pletcher
Scott F. Leiser
author_facet Hillary A. Miller
Shijiao Huang
Elizabeth S. Dean
Megan L. Schaller
Angela M. Tuckowski
Allyson S. Munneke
Safa Beydoun
Scott D. Pletcher
Scott F. Leiser
author_sort Hillary A. Miller
collection DOAJ
description This report finds that dietary restriction, the most extensively studied anti-aging intervention, can be mimicked by blocking food odour signaling and identifies a neural network of food perception that functions through serotonin and dopamine.
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spelling doaj.art-3c3039c8eb084652ba7863dcb87238192022-12-22T03:27:27ZengNature PortfolioNature Communications2041-17232022-06-0113111310.1038/s41467-022-30869-5Serotonin and dopamine modulate aging in response to food odor and availabilityHillary A. Miller0Shijiao Huang1Elizabeth S. Dean2Megan L. Schaller3Angela M. Tuckowski4Allyson S. Munneke5Safa Beydoun6Scott D. Pletcher7Scott F. Leiser8Cellular and Molecular Biology Program, University of MichiganMolecular & Integrative Physiology Department, University of MichiganMolecular & Integrative Physiology Department, University of MichiganMolecular & Integrative Physiology Department, University of MichiganCellular and Molecular Biology Program, University of MichiganCellular and Molecular Biology Program, University of MichiganMolecular & Integrative Physiology Department, University of MichiganMolecular & Integrative Physiology Department, University of MichiganMolecular & Integrative Physiology Department, University of MichiganThis report finds that dietary restriction, the most extensively studied anti-aging intervention, can be mimicked by blocking food odour signaling and identifies a neural network of food perception that functions through serotonin and dopamine.https://doi.org/10.1038/s41467-022-30869-5
spellingShingle Hillary A. Miller
Shijiao Huang
Elizabeth S. Dean
Megan L. Schaller
Angela M. Tuckowski
Allyson S. Munneke
Safa Beydoun
Scott D. Pletcher
Scott F. Leiser
Serotonin and dopamine modulate aging in response to food odor and availability
Nature Communications
title Serotonin and dopamine modulate aging in response to food odor and availability
title_full Serotonin and dopamine modulate aging in response to food odor and availability
title_fullStr Serotonin and dopamine modulate aging in response to food odor and availability
title_full_unstemmed Serotonin and dopamine modulate aging in response to food odor and availability
title_short Serotonin and dopamine modulate aging in response to food odor and availability
title_sort serotonin and dopamine modulate aging in response to food odor and availability
url https://doi.org/10.1038/s41467-022-30869-5
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