The Novel Role of Noncoding RNAs in Modulating Platelet Function: Implications in Activation and Aggregation
It is currently believed that plaque complication, with the consequent superimposed thrombosis, is a key factor in the clinical occurrence of acute coronary syndromes (ACSs). Platelets are major players in this process. Despite the considerable progress made by the new antithrombotic strategies (P2Y...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/8/7650 |
| _version_ | 1797605003302535168 |
|---|---|
| author | Giovanni Cimmino Stefano Conte Domenico Palumbo Simona Sperlongano Michele Torella Alessandro Della Corte Paolo Golino |
| author_facet | Giovanni Cimmino Stefano Conte Domenico Palumbo Simona Sperlongano Michele Torella Alessandro Della Corte Paolo Golino |
| author_sort | Giovanni Cimmino |
| collection | DOAJ |
| description | It is currently believed that plaque complication, with the consequent superimposed thrombosis, is a key factor in the clinical occurrence of acute coronary syndromes (ACSs). Platelets are major players in this process. Despite the considerable progress made by the new antithrombotic strategies (P2Y12 receptor inhibitors, new oral anticoagulants, thrombin direct inhibitors, etc.) in terms of a reduction in major cardiovascular events, a significant number of patients with previous ACSs treated with these drugs continue to experience events, indicating that the mechanisms of platelet remain largely unknown. In the last decade, our knowledge of platelet pathophysiology has improved. It has been reported that, in response to physiological and pathological stimuli, platelet activation is accompanied by de novo protein synthesis, through a rapid and particularly well-regulated translation of resident mRNAs of megakaryocytic derivation. Although the platelets are anucleate, they indeed contain an important fraction of mRNAs that can be quickly used for protein synthesis following their activation. A better understanding of the pathophysiology of platelet activation and the interaction with the main cellular components of the vascular wall will open up new perspectives in the treatment of the majority of thrombotic disorders, such as ACSs, stroke, and peripheral artery diseases before and after the acute event. In the present review, we will discuss the novel role of noncoding RNAs in modulating platelet function, highlighting the possible implications in activation and aggregation. |
| first_indexed | 2024-03-11T04:54:53Z |
| format | Article |
| id | doaj.art-3c323d79bfd84232aa395b5cd12149ff |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:54:53Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3c323d79bfd84232aa395b5cd12149ff2023-11-17T19:43:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248765010.3390/ijms24087650The Novel Role of Noncoding RNAs in Modulating Platelet Function: Implications in Activation and AggregationGiovanni Cimmino0Stefano Conte1Domenico Palumbo2Simona Sperlongano3Michele Torella4Alessandro Della Corte5Paolo Golino6Department of Translational Medical Sciences, Section of Cardiology, University of Campania Luigi Vanvitelli, L. Bianchi Street, 80131 Naples, ItalyDepartment of Translational Medical Sciences, Section of Lung Diseases, University of Campania Luigi Vanvitelli, L. Bianchi Street, 80131 Naples, ItalyDepartment of Translational Medical Sciences, Section of Cardiology, University of Campania Luigi Vanvitelli, L. Bianchi Street, 80131 Naples, ItalyDepartment of Translational Medical Sciences, Section of Cardiology, University of Campania Luigi Vanvitelli, L. Bianchi Street, 80131 Naples, ItalyDepartment of Translational Medical Sciences, Section of Cardiology, University of Campania Luigi Vanvitelli, L. Bianchi Street, 80131 Naples, ItalyDepartment of Translational Medical Sciences, Section of Cardiology, University of Campania Luigi Vanvitelli, L. Bianchi Street, 80131 Naples, ItalyDepartment of Translational Medical Sciences, Section of Cardiology, University of Campania Luigi Vanvitelli, L. Bianchi Street, 80131 Naples, ItalyIt is currently believed that plaque complication, with the consequent superimposed thrombosis, is a key factor in the clinical occurrence of acute coronary syndromes (ACSs). Platelets are major players in this process. Despite the considerable progress made by the new antithrombotic strategies (P2Y12 receptor inhibitors, new oral anticoagulants, thrombin direct inhibitors, etc.) in terms of a reduction in major cardiovascular events, a significant number of patients with previous ACSs treated with these drugs continue to experience events, indicating that the mechanisms of platelet remain largely unknown. In the last decade, our knowledge of platelet pathophysiology has improved. It has been reported that, in response to physiological and pathological stimuli, platelet activation is accompanied by de novo protein synthesis, through a rapid and particularly well-regulated translation of resident mRNAs of megakaryocytic derivation. Although the platelets are anucleate, they indeed contain an important fraction of mRNAs that can be quickly used for protein synthesis following their activation. A better understanding of the pathophysiology of platelet activation and the interaction with the main cellular components of the vascular wall will open up new perspectives in the treatment of the majority of thrombotic disorders, such as ACSs, stroke, and peripheral artery diseases before and after the acute event. In the present review, we will discuss the novel role of noncoding RNAs in modulating platelet function, highlighting the possible implications in activation and aggregation.https://www.mdpi.com/1422-0067/24/8/7650platelet activationplatelet transcriptomeplatelet proteomethrombosis |
| spellingShingle | Giovanni Cimmino Stefano Conte Domenico Palumbo Simona Sperlongano Michele Torella Alessandro Della Corte Paolo Golino The Novel Role of Noncoding RNAs in Modulating Platelet Function: Implications in Activation and Aggregation International Journal of Molecular Sciences platelet activation platelet transcriptome platelet proteome thrombosis |
| title | The Novel Role of Noncoding RNAs in Modulating Platelet Function: Implications in Activation and Aggregation |
| title_full | The Novel Role of Noncoding RNAs in Modulating Platelet Function: Implications in Activation and Aggregation |
| title_fullStr | The Novel Role of Noncoding RNAs in Modulating Platelet Function: Implications in Activation and Aggregation |
| title_full_unstemmed | The Novel Role of Noncoding RNAs in Modulating Platelet Function: Implications in Activation and Aggregation |
| title_short | The Novel Role of Noncoding RNAs in Modulating Platelet Function: Implications in Activation and Aggregation |
| title_sort | novel role of noncoding rnas in modulating platelet function implications in activation and aggregation |
| topic | platelet activation platelet transcriptome platelet proteome thrombosis |
| url | https://www.mdpi.com/1422-0067/24/8/7650 |
| work_keys_str_mv | AT giovannicimmino thenovelroleofnoncodingrnasinmodulatingplateletfunctionimplicationsinactivationandaggregation AT stefanoconte thenovelroleofnoncodingrnasinmodulatingplateletfunctionimplicationsinactivationandaggregation AT domenicopalumbo thenovelroleofnoncodingrnasinmodulatingplateletfunctionimplicationsinactivationandaggregation AT simonasperlongano thenovelroleofnoncodingrnasinmodulatingplateletfunctionimplicationsinactivationandaggregation AT micheletorella thenovelroleofnoncodingrnasinmodulatingplateletfunctionimplicationsinactivationandaggregation AT alessandrodellacorte thenovelroleofnoncodingrnasinmodulatingplateletfunctionimplicationsinactivationandaggregation AT paologolino thenovelroleofnoncodingrnasinmodulatingplateletfunctionimplicationsinactivationandaggregation AT giovannicimmino novelroleofnoncodingrnasinmodulatingplateletfunctionimplicationsinactivationandaggregation AT stefanoconte novelroleofnoncodingrnasinmodulatingplateletfunctionimplicationsinactivationandaggregation AT domenicopalumbo novelroleofnoncodingrnasinmodulatingplateletfunctionimplicationsinactivationandaggregation AT simonasperlongano novelroleofnoncodingrnasinmodulatingplateletfunctionimplicationsinactivationandaggregation AT micheletorella novelroleofnoncodingrnasinmodulatingplateletfunctionimplicationsinactivationandaggregation AT alessandrodellacorte novelroleofnoncodingrnasinmodulatingplateletfunctionimplicationsinactivationandaggregation AT paologolino novelroleofnoncodingrnasinmodulatingplateletfunctionimplicationsinactivationandaggregation |