Computerized assessment of social approach behavior in mouse
Altered sociability is a core feature of a variety of human neurological disorders, including autism. Social behaviors may be tested in animal models, such as mice, to study the biological bases of sociability and how this is altered in neurodevelopmental disorders. An easily quantifiable social beh...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2009-11-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/neuro.08.048.2009/full |
| _version_ | 1817981189831524352 |
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| author | Damon T Page Damon T Page Orsolya J Kuti Orsolya J Kuti Mriganka Sur Mriganka Sur |
| author_facet | Damon T Page Damon T Page Orsolya J Kuti Orsolya J Kuti Mriganka Sur Mriganka Sur |
| author_sort | Damon T Page |
| collection | DOAJ |
| description | Altered sociability is a core feature of a variety of human neurological disorders, including autism. Social behaviors may be tested in animal models, such as mice, to study the biological bases of sociability and how this is altered in neurodevelopmental disorders. An easily quantifiable social behavior frequently used to assess sociability in the mouse is the tendency to approach and interact with an unfamiliar mouse. Here we present a novel computer-assisted method for scoring social approach behavior in mice using a three-chambered apparatus. We find consistent results between data scored using the computer assisted method and a human observer, making computerized assessment a reliable, low cost, high-throughput method for testing sociability. |
| first_indexed | 2024-04-13T23:02:40Z |
| format | Article |
| id | doaj.art-3c34044066ce41e8aa643346a970455d |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-13T23:02:40Z |
| publishDate | 2009-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-3c34044066ce41e8aa643346a970455d2022-12-22T02:25:46ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532009-11-01310.3389/neuro.08.048.2009888Computerized assessment of social approach behavior in mouseDamon T Page0Damon T Page1Orsolya J Kuti2Orsolya J Kuti3Mriganka Sur4Mriganka Sur5Massachusetts Institute of TechnologyMassachusetts Institute of TechnologyMassachusetts Institute of TechnologyMassachusetts Institute of TechnologyMassachusetts Institute of TechnologyMassachusetts Institute of TechnologyAltered sociability is a core feature of a variety of human neurological disorders, including autism. Social behaviors may be tested in animal models, such as mice, to study the biological bases of sociability and how this is altered in neurodevelopmental disorders. An easily quantifiable social behavior frequently used to assess sociability in the mouse is the tendency to approach and interact with an unfamiliar mouse. Here we present a novel computer-assisted method for scoring social approach behavior in mice using a three-chambered apparatus. We find consistent results between data scored using the computer assisted method and a human observer, making computerized assessment a reliable, low cost, high-throughput method for testing sociability.http://journal.frontiersin.org/Journal/10.3389/neuro.08.048.2009/fullBehaviorGeneticsautismDA turnoversocial approach |
| spellingShingle | Damon T Page Damon T Page Orsolya J Kuti Orsolya J Kuti Mriganka Sur Mriganka Sur Computerized assessment of social approach behavior in mouse Frontiers in Behavioral Neuroscience Behavior Genetics autism DA turnover social approach |
| title | Computerized assessment of social approach behavior in mouse |
| title_full | Computerized assessment of social approach behavior in mouse |
| title_fullStr | Computerized assessment of social approach behavior in mouse |
| title_full_unstemmed | Computerized assessment of social approach behavior in mouse |
| title_short | Computerized assessment of social approach behavior in mouse |
| title_sort | computerized assessment of social approach behavior in mouse |
| topic | Behavior Genetics autism DA turnover social approach |
| url | http://journal.frontiersin.org/Journal/10.3389/neuro.08.048.2009/full |
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