Glycated Albumin, a Novel Biomarker for Short-Term Functional Outcomes in Acute Ischemic Stroke
<i>Background:</i> There is growing interest in the use of new biomarkers such as glycated albumin (GA), but data are limited in acute ischemic stroke. We explored the impact of GA on short-term functional outcomes as measured using the modified Rankin Scale (mRS) at 3 months compared to...
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MDPI AG
2021-03-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/3/337 |
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| author | Yerim Kim Sang-Hwa Lee Min Kyoung Kang Tae Jung Kim Han-Yeong Jeong Eung-Joon Lee Jeonghoon Bae Kipyoung Jeon Ki-Woong Nam Byung-Woo Yoon |
| author_facet | Yerim Kim Sang-Hwa Lee Min Kyoung Kang Tae Jung Kim Han-Yeong Jeong Eung-Joon Lee Jeonghoon Bae Kipyoung Jeon Ki-Woong Nam Byung-Woo Yoon |
| author_sort | Yerim Kim |
| collection | DOAJ |
| description | <i>Background:</i> There is growing interest in the use of new biomarkers such as glycated albumin (GA), but data are limited in acute ischemic stroke. We explored the impact of GA on short-term functional outcomes as measured using the modified Rankin Scale (mRS) at 3 months compared to glycated hemoglobin (HbA1c). <i>Methods:</i> A total of 1163 AIS patients from two hospitals between 2016 and 2019 were included. Patients were divided into two groups according to GA levels (GA < 16% versus GA ≥ 16%). <i>Results:</i> A total of 518 patients (44.5%) were included in the GA ≥ 16% group. After adjusting for multiple covariates, the higher GA group (GA ≥ 16%) had a 1.4-fold risk of having unfavorable mRS (95% CI 1.02–1.847). However, HbA1c was not significantly associated with 3-month mRS. In addition, GA ≥ 16% was independently associated with unfavorable short-term outcomes only in patients without diabetes. <i>Conclusions:</i> In light of these results, GA level might be a novel prognostic biomarker compared to HbA1c for short-term stroke outcome. Although the impact of GA is undervalued in the current stroke guidelines, GA monitoring should be considered in addition to HbA1c monitoring. |
| first_indexed | 2024-03-09T05:08:54Z |
| format | Article |
| id | doaj.art-3c34f7cdc3fe495dbd67a929504c9d79 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T05:08:54Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-3c34f7cdc3fe495dbd67a929504c9d792023-12-03T12:51:03ZengMDPI AGBrain Sciences2076-34252021-03-0111333710.3390/brainsci11030337Glycated Albumin, a Novel Biomarker for Short-Term Functional Outcomes in Acute Ischemic StrokeYerim Kim0Sang-Hwa Lee1Min Kyoung Kang2Tae Jung Kim3Han-Yeong Jeong4Eung-Joon Lee5Jeonghoon Bae6Kipyoung Jeon7Ki-Woong Nam8Byung-Woo Yoon9Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul 05355, KoreaDepartment of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24253, KoreaDepartment of Neurology, Uijeongbu Eulji Medical Center, Eulji University College of Medicine, Uijeonbu-si 11759, KoreaDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, KoreaEmergency Medical Center, Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul 03080, KoreaDepartment of Neurology, Uijeongbu Eulji Medical Center, Eulji University College of Medicine, Uijeonbu-si 11759, Korea<i>Background:</i> There is growing interest in the use of new biomarkers such as glycated albumin (GA), but data are limited in acute ischemic stroke. We explored the impact of GA on short-term functional outcomes as measured using the modified Rankin Scale (mRS) at 3 months compared to glycated hemoglobin (HbA1c). <i>Methods:</i> A total of 1163 AIS patients from two hospitals between 2016 and 2019 were included. Patients were divided into two groups according to GA levels (GA < 16% versus GA ≥ 16%). <i>Results:</i> A total of 518 patients (44.5%) were included in the GA ≥ 16% group. After adjusting for multiple covariates, the higher GA group (GA ≥ 16%) had a 1.4-fold risk of having unfavorable mRS (95% CI 1.02–1.847). However, HbA1c was not significantly associated with 3-month mRS. In addition, GA ≥ 16% was independently associated with unfavorable short-term outcomes only in patients without diabetes. <i>Conclusions:</i> In light of these results, GA level might be a novel prognostic biomarker compared to HbA1c for short-term stroke outcome. Although the impact of GA is undervalued in the current stroke guidelines, GA monitoring should be considered in addition to HbA1c monitoring.https://www.mdpi.com/2076-3425/11/3/337glycated albuminglycated hemoglobinbrain ischemiastrokeprognosisbiomarkers |
| spellingShingle | Yerim Kim Sang-Hwa Lee Min Kyoung Kang Tae Jung Kim Han-Yeong Jeong Eung-Joon Lee Jeonghoon Bae Kipyoung Jeon Ki-Woong Nam Byung-Woo Yoon Glycated Albumin, a Novel Biomarker for Short-Term Functional Outcomes in Acute Ischemic Stroke Brain Sciences glycated albumin glycated hemoglobin brain ischemia stroke prognosis biomarkers |
| title | Glycated Albumin, a Novel Biomarker for Short-Term Functional Outcomes in Acute Ischemic Stroke |
| title_full | Glycated Albumin, a Novel Biomarker for Short-Term Functional Outcomes in Acute Ischemic Stroke |
| title_fullStr | Glycated Albumin, a Novel Biomarker for Short-Term Functional Outcomes in Acute Ischemic Stroke |
| title_full_unstemmed | Glycated Albumin, a Novel Biomarker for Short-Term Functional Outcomes in Acute Ischemic Stroke |
| title_short | Glycated Albumin, a Novel Biomarker for Short-Term Functional Outcomes in Acute Ischemic Stroke |
| title_sort | glycated albumin a novel biomarker for short term functional outcomes in acute ischemic stroke |
| topic | glycated albumin glycated hemoglobin brain ischemia stroke prognosis biomarkers |
| url | https://www.mdpi.com/2076-3425/11/3/337 |
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