Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia
Induced pluripotent stem cells (iPSCs) are a self-renewable pool of cells derived from an organism’s somatic cells. These can then be programmed to other cell types, including neurons. Use of iPSCs in research has been two-fold as they have been used for human disease modelling as well as for the po...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/9/4334 |
| _version_ | 1797536840692006912 |
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| author | Katrina Albert Jonna Niskanen Sara Kälvälä Šárka Lehtonen |
| author_facet | Katrina Albert Jonna Niskanen Sara Kälvälä Šárka Lehtonen |
| author_sort | Katrina Albert |
| collection | DOAJ |
| description | Induced pluripotent stem cells (iPSCs) are a self-renewable pool of cells derived from an organism’s somatic cells. These can then be programmed to other cell types, including neurons. Use of iPSCs in research has been two-fold as they have been used for human disease modelling as well as for the possibility to generate new therapies. Particularly in complex human diseases, such as neurodegenerative diseases, iPSCs can give advantages over traditional animal models in that they more accurately represent the human genome. Additionally, patient-derived cells can be modified using gene editing technology and further transplanted to the brain. Glial cells have recently become important avenues of research in the field of neurodegenerative diseases, for example, in Alzheimer’s disease and Parkinson’s disease. This review focuses on using glial cells (astrocytes, microglia, and oligodendrocytes) derived from human iPSCs in order to give a better understanding of how these cells contribute to neurodegenerative disease pathology. Using glia iPSCs in in vitro cell culture, cerebral organoids, and intracranial transplantation may give us future insight into both more accurate models and disease-modifying therapies. |
| first_indexed | 2024-03-10T12:06:32Z |
| format | Article |
| id | doaj.art-3c3679c61a9443cd9c0646dcf76398b5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:06:32Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3c3679c61a9443cd9c0646dcf76398b52023-11-21T16:31:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01229433410.3390/ijms22094334Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on GliaKatrina Albert0Jonna Niskanen1Sara Kälvälä2Šárka Lehtonen3Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UKA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, FinlandInduced pluripotent stem cells (iPSCs) are a self-renewable pool of cells derived from an organism’s somatic cells. These can then be programmed to other cell types, including neurons. Use of iPSCs in research has been two-fold as they have been used for human disease modelling as well as for the possibility to generate new therapies. Particularly in complex human diseases, such as neurodegenerative diseases, iPSCs can give advantages over traditional animal models in that they more accurately represent the human genome. Additionally, patient-derived cells can be modified using gene editing technology and further transplanted to the brain. Glial cells have recently become important avenues of research in the field of neurodegenerative diseases, for example, in Alzheimer’s disease and Parkinson’s disease. This review focuses on using glial cells (astrocytes, microglia, and oligodendrocytes) derived from human iPSCs in order to give a better understanding of how these cells contribute to neurodegenerative disease pathology. Using glia iPSCs in in vitro cell culture, cerebral organoids, and intracranial transplantation may give us future insight into both more accurate models and disease-modifying therapies.https://www.mdpi.com/1422-0067/22/9/4334astrocytesmicrogliaoligodendrocytesinduced pluripotent stem cellstransplantation, organoidsneurodegenerative disease |
| spellingShingle | Katrina Albert Jonna Niskanen Sara Kälvälä Šárka Lehtonen Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia International Journal of Molecular Sciences astrocytes microglia oligodendrocytes induced pluripotent stem cells transplantation, organoids neurodegenerative disease |
| title | Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia |
| title_full | Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia |
| title_fullStr | Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia |
| title_full_unstemmed | Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia |
| title_short | Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia |
| title_sort | utilising induced pluripotent stem cells in neurodegenerative disease research focus on glia |
| topic | astrocytes microglia oligodendrocytes induced pluripotent stem cells transplantation, organoids neurodegenerative disease |
| url | https://www.mdpi.com/1422-0067/22/9/4334 |
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