Factors associated with the survival of colorectal cancer in Mexico
Background/Aims Colorectal cancer (CRC) is a public health problem. In Mexico, there have been no recent studies conducted on survival in terms of this pathology or on the influence of prognostic factors. The study aims to determine the probability of survival in patients with CRC presence of low le...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of Intestinal Diseases
2020-07-01
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| Series: | Intestinal Research |
| Subjects: | |
| Online Access: | http://www.irjournal.org/upload/pdf/ir-2019-09179.pdf |
| _version_ | 1819081925366644736 |
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| author | Carlos Quezada-Gutiérrez María Teresa Álvarez-Bañuelos Jaime Morales-Romero Clara Luz Sampieri Raúl Enrique Guzmán-García Evangelina Montes-Villaseñor |
| author_facet | Carlos Quezada-Gutiérrez María Teresa Álvarez-Bañuelos Jaime Morales-Romero Clara Luz Sampieri Raúl Enrique Guzmán-García Evangelina Montes-Villaseñor |
| author_sort | Carlos Quezada-Gutiérrez |
| collection | DOAJ |
| description | Background/Aims Colorectal cancer (CRC) is a public health problem. In Mexico, there have been no recent studies conducted on survival in terms of this pathology or on the influence of prognostic factors. The study aims to determine the probability of survival in patients with CRC presence of low levels of schooling and a rural population, adjusted for clinical stage and type of treatment. Methods A retrospective study was conducted in a cohort of 305 patients with CRC treated at State Cancer Center, located in Veracruz-Mexico; the follow-up period of 60 months (2012–2016). The survival probability was calculated using the Kaplan-Meier estimator and the log-rank test with 95% confidence intervals (CIs). Prognostic factors were determined using hazard ratio (HR) multivariate Cox regression analysis. Results Overall survival was 40% at 60 months. Subjects in the age group ≥ 65 years had a low survival rate of 28% (P=0.026) and an advanced clinical stage of 22% (P<0.001). Of the patients with bone metastasis, none survived longer than 5 years (P=0.008). With respect to the unfavorable prognostic factors identified in the multivariate analysis, a decreased level of schooling was associated with an HR of 7.6 (95% CI, 1.1–54.7), advanced clinical stage was associated with an HR of 2.1 (95% CI, 1.2–4.0), and the presence of metastasis had an HR of 1.8 (95% CI, 1.1–2.9). Conclusions Poor prognostic factors include an advanced clinical stage, the presence of metastasis and a low level of schooling. These findings confirm the importance of screening for early diagnosis, diminishing the barriers to accessing treatment and prospectively monitoring the population. |
| first_indexed | 2024-12-21T20:08:31Z |
| format | Article |
| id | doaj.art-3c382104031042a8b7efc71fd9355a63 |
| institution | Directory Open Access Journal |
| issn | 1598-9100 2288-1956 |
| language | English |
| last_indexed | 2024-12-21T20:08:31Z |
| publishDate | 2020-07-01 |
| publisher | Korean Association for the Study of Intestinal Diseases |
| record_format | Article |
| series | Intestinal Research |
| spelling | doaj.art-3c382104031042a8b7efc71fd9355a632022-12-21T18:51:46ZengKorean Association for the Study of Intestinal DiseasesIntestinal Research1598-91002288-19562020-07-0118331532410.5217/ir.2019.09179842Factors associated with the survival of colorectal cancer in MexicoCarlos Quezada-Gutiérrez0María Teresa Álvarez-Bañuelos1Jaime Morales-Romero2Clara Luz Sampieri3Raúl Enrique Guzmán-García4Evangelina Montes-Villaseñor5 Institute of Public Health, Veracruzana University, Veracruz, Mexico Institute of Public Health, Veracruzana University, Veracruz, Mexico Institute of Public Health, Veracruzana University, Veracruz, Mexico Institute of Public Health, Veracruzana University, Veracruz, Mexico State Cancer Center, Secretary of Health of the State of Veracruz, Veracruz, Mexico State Cancer Center, Secretary of Health of the State of Veracruz, Veracruz, MexicoBackground/Aims Colorectal cancer (CRC) is a public health problem. In Mexico, there have been no recent studies conducted on survival in terms of this pathology or on the influence of prognostic factors. The study aims to determine the probability of survival in patients with CRC presence of low levels of schooling and a rural population, adjusted for clinical stage and type of treatment. Methods A retrospective study was conducted in a cohort of 305 patients with CRC treated at State Cancer Center, located in Veracruz-Mexico; the follow-up period of 60 months (2012–2016). The survival probability was calculated using the Kaplan-Meier estimator and the log-rank test with 95% confidence intervals (CIs). Prognostic factors were determined using hazard ratio (HR) multivariate Cox regression analysis. Results Overall survival was 40% at 60 months. Subjects in the age group ≥ 65 years had a low survival rate of 28% (P=0.026) and an advanced clinical stage of 22% (P<0.001). Of the patients with bone metastasis, none survived longer than 5 years (P=0.008). With respect to the unfavorable prognostic factors identified in the multivariate analysis, a decreased level of schooling was associated with an HR of 7.6 (95% CI, 1.1–54.7), advanced clinical stage was associated with an HR of 2.1 (95% CI, 1.2–4.0), and the presence of metastasis had an HR of 1.8 (95% CI, 1.1–2.9). Conclusions Poor prognostic factors include an advanced clinical stage, the presence of metastasis and a low level of schooling. These findings confirm the importance of screening for early diagnosis, diminishing the barriers to accessing treatment and prospectively monitoring the population.http://www.irjournal.org/upload/pdf/ir-2019-09179.pdfcolorectal neoplasmssurvivalmetastasislymphatic nodeclinical stage |
| spellingShingle | Carlos Quezada-Gutiérrez María Teresa Álvarez-Bañuelos Jaime Morales-Romero Clara Luz Sampieri Raúl Enrique Guzmán-García Evangelina Montes-Villaseñor Factors associated with the survival of colorectal cancer in Mexico Intestinal Research colorectal neoplasms survival metastasis lymphatic node clinical stage |
| title | Factors associated with the survival of colorectal cancer in Mexico |
| title_full | Factors associated with the survival of colorectal cancer in Mexico |
| title_fullStr | Factors associated with the survival of colorectal cancer in Mexico |
| title_full_unstemmed | Factors associated with the survival of colorectal cancer in Mexico |
| title_short | Factors associated with the survival of colorectal cancer in Mexico |
| title_sort | factors associated with the survival of colorectal cancer in mexico |
| topic | colorectal neoplasms survival metastasis lymphatic node clinical stage |
| url | http://www.irjournal.org/upload/pdf/ir-2019-09179.pdf |
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