Straightforward and robust synthesis of monodisperse surface-functionalized gold nanoclusters
Gold nanoclusters are small (1–3 nm) nanoparticles with a high surface area that are useful for biomedical studies and drug delivery. The synthesis of small, surface-functionalized gold nanoclusters is greatly dependent on the reaction conditions. Here, we describe a straightforward, efficient and r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2016-09-01
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| Series: | Beilstein Journal of Nanotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjnano.7.118 |
| _version_ | 1828435596336431104 |
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| author | Silvia Varela-Aramburu Richard Wirth Chian-Hui Lai Guillermo Orts-Gil Peter H. Seeberger |
| author_facet | Silvia Varela-Aramburu Richard Wirth Chian-Hui Lai Guillermo Orts-Gil Peter H. Seeberger |
| author_sort | Silvia Varela-Aramburu |
| collection | DOAJ |
| description | Gold nanoclusters are small (1–3 nm) nanoparticles with a high surface area that are useful for biomedical studies and drug delivery. The synthesis of small, surface-functionalized gold nanoclusters is greatly dependent on the reaction conditions. Here, we describe a straightforward, efficient and robust room temperature one-pot synthesis of 2 nm gold nanoclusters using thioglucose as a reducing and stabilizing agent, which was discovered by serendipity. The resultant monodisperse gold nanoclusters are more stable than those generated using some other common methods. The carboxylic acid contained in the stabilizing agent on the cluster surface serves as anchor for nanocluster functionalization. Alternatively, the addition of thiols serves to functionalize the nanoclusters. The resulting non-cytotoxic nanoclusters are taken up by cells and constitute a tuneable platform for biomedical applications including drug delivery. |
| first_indexed | 2024-12-10T19:09:56Z |
| format | Article |
| id | doaj.art-3c3839c9879347dbb39de715a5c6e80d |
| institution | Directory Open Access Journal |
| issn | 2190-4286 |
| language | English |
| last_indexed | 2024-12-10T19:09:56Z |
| publishDate | 2016-09-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Nanotechnology |
| spelling | doaj.art-3c3839c9879347dbb39de715a5c6e80d2022-12-22T01:36:46ZengBeilstein-InstitutBeilstein Journal of Nanotechnology2190-42862016-09-01711278128310.3762/bjnano.7.1182190-4286-7-118Straightforward and robust synthesis of monodisperse surface-functionalized gold nanoclustersSilvia Varela-Aramburu0Richard Wirth1Chian-Hui Lai2Guillermo Orts-Gil3Peter H. Seeberger4Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Mühlenberg 1, 14476 Potsdam, GermanyHelmholtz Centre Potsdam GFZ German Research Centre for Geosciences, Sec. 4.3, Telegrafenberg, 14473 Potsdam, GermanyMax Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Mühlenberg 1, 14476 Potsdam, GermanyMax Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Mühlenberg 1, 14476 Potsdam, GermanyMax Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Mühlenberg 1, 14476 Potsdam, GermanyGold nanoclusters are small (1–3 nm) nanoparticles with a high surface area that are useful for biomedical studies and drug delivery. The synthesis of small, surface-functionalized gold nanoclusters is greatly dependent on the reaction conditions. Here, we describe a straightforward, efficient and robust room temperature one-pot synthesis of 2 nm gold nanoclusters using thioglucose as a reducing and stabilizing agent, which was discovered by serendipity. The resultant monodisperse gold nanoclusters are more stable than those generated using some other common methods. The carboxylic acid contained in the stabilizing agent on the cluster surface serves as anchor for nanocluster functionalization. Alternatively, the addition of thiols serves to functionalize the nanoclusters. The resulting non-cytotoxic nanoclusters are taken up by cells and constitute a tuneable platform for biomedical applications including drug delivery.https://doi.org/10.3762/bjnano.7.118biomedical applicationscarbohydratesfunctionalizationgold nanoclustersrobust |
| spellingShingle | Silvia Varela-Aramburu Richard Wirth Chian-Hui Lai Guillermo Orts-Gil Peter H. Seeberger Straightforward and robust synthesis of monodisperse surface-functionalized gold nanoclusters Beilstein Journal of Nanotechnology biomedical applications carbohydrates functionalization gold nanoclusters robust |
| title | Straightforward and robust synthesis of monodisperse surface-functionalized gold nanoclusters |
| title_full | Straightforward and robust synthesis of monodisperse surface-functionalized gold nanoclusters |
| title_fullStr | Straightforward and robust synthesis of monodisperse surface-functionalized gold nanoclusters |
| title_full_unstemmed | Straightforward and robust synthesis of monodisperse surface-functionalized gold nanoclusters |
| title_short | Straightforward and robust synthesis of monodisperse surface-functionalized gold nanoclusters |
| title_sort | straightforward and robust synthesis of monodisperse surface functionalized gold nanoclusters |
| topic | biomedical applications carbohydrates functionalization gold nanoclusters robust |
| url | https://doi.org/10.3762/bjnano.7.118 |
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