ACTH-CYTOKINE ASSOCIATIONS IN THE «SKIN WINDOW» EXUDATES IN ATOPIC DERMATITIS
Currently, atopic dermatitis is one of the most common chronic recurrent skin diseases, and, furthermore, the first manifestation of atopy. The pathogenesis of this disease has not been fully studied, it is multifaceted, since it is a pathogenic combination of the tridirectional interaction between...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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The Publishing House Medicine and Enlightenment
2023-12-01
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| Series: | Medicina v Kuzbasse |
| Subjects: | |
| Online Access: | https://mednauki.ru/index.php/MK/article/view/997 |
| _version_ | 1797353455867658240 |
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| author | Денис Сергеевич Загрешенко Владимир Васильевич Климов Наталья Александровна Трофименко Маргарита Сергеевна Дорофеева |
| author_facet | Денис Сергеевич Загрешенко Владимир Васильевич Климов Наталья Александровна Трофименко Маргарита Сергеевна Дорофеева |
| author_sort | Денис Сергеевич Загрешенко |
| collection | DOAJ |
| description | Currently, atopic dermatitis is one of the most common chronic recurrent skin diseases, and, furthermore, the first manifestation of atopy. The pathogenesis of this disease has not been fully studied, it is multifaceted, since it is a pathogenic combination of the tridirectional interaction between the nervous, endocrine and immune systems both at the whole body level and level of the largest barrier organ, which is the skin. In addition, genetic, epigenetic, and environmental factors contribute to atopic dermatitis pathogenesis significantly. The use of the «skin window» model, values of adrenocorticotropic hormone (ACTH) and inflammasome associated cytokines were determined in skin exudates.
19 patients with exacerbation forms of atopic dermatitis and 25 volunteers were examined. It has been revealed that in the clinical group of patients, the values of ACTH was significantly reduced compared to the control group, whereas the content of IL-1ß, IL-18, IL-6, and TNF-α in the exudates of the «skin window» in atopic dermatitis essentially exceeded control parameters.
The data obtained illustrate the dysregulation condition between the endocrine and immune systems at the skin level reduce the anti-inflammatory potential of the skin and increase pro-inflammatory activity. Cytokine overproduction is related to pro-inflammatory cytokines, which are essential for inflammasomes activation in the skin. |
| first_indexed | 2024-03-08T13:31:23Z |
| format | Article |
| id | doaj.art-3c38b7b8397743848c7e4240c1b7e81b |
| institution | Directory Open Access Journal |
| issn | 1819-0901 2588-0411 |
| language | Russian |
| last_indexed | 2024-03-08T13:31:23Z |
| publishDate | 2023-12-01 |
| publisher | The Publishing House Medicine and Enlightenment |
| record_format | Article |
| series | Medicina v Kuzbasse |
| spelling | doaj.art-3c38b7b8397743848c7e4240c1b7e81b2024-01-17T08:28:25ZrusThe Publishing House Medicine and EnlightenmentMedicina v Kuzbasse1819-09012588-04112023-12-012244851866ACTH-CYTOKINE ASSOCIATIONS IN THE «SKIN WINDOW» EXUDATES IN ATOPIC DERMATITISДенис Сергеевич Загрешенко0Владимир Васильевич Климов1Наталья Александровна Трофименко2Маргарита Сергеевна Дорофеева3НГИУВ – филиал ФГБОУ ДПО РМАНПО Минздрава России, г. НовокузнецкФГБОУ ВО СибГМУ, г. ТомскГАУЗ «НГКБ № 1 им. Г.П. Курбатова», г. НовокузнецкГБУЗ Новокузнецкий наркологический диспансер, г. НовокузнецкCurrently, atopic dermatitis is one of the most common chronic recurrent skin diseases, and, furthermore, the first manifestation of atopy. The pathogenesis of this disease has not been fully studied, it is multifaceted, since it is a pathogenic combination of the tridirectional interaction between the nervous, endocrine and immune systems both at the whole body level and level of the largest barrier organ, which is the skin. In addition, genetic, epigenetic, and environmental factors contribute to atopic dermatitis pathogenesis significantly. The use of the «skin window» model, values of adrenocorticotropic hormone (ACTH) and inflammasome associated cytokines were determined in skin exudates. 19 patients with exacerbation forms of atopic dermatitis and 25 volunteers were examined. It has been revealed that in the clinical group of patients, the values of ACTH was significantly reduced compared to the control group, whereas the content of IL-1ß, IL-18, IL-6, and TNF-α in the exudates of the «skin window» in atopic dermatitis essentially exceeded control parameters. The data obtained illustrate the dysregulation condition between the endocrine and immune systems at the skin level reduce the anti-inflammatory potential of the skin and increase pro-inflammatory activity. Cytokine overproduction is related to pro-inflammatory cytokines, which are essential for inflammasomes activation in the skin.https://mednauki.ru/index.php/MK/article/view/997атопический дерматитцитокины«кожное окно»актг |
| spellingShingle | Денис Сергеевич Загрешенко Владимир Васильевич Климов Наталья Александровна Трофименко Маргарита Сергеевна Дорофеева ACTH-CYTOKINE ASSOCIATIONS IN THE «SKIN WINDOW» EXUDATES IN ATOPIC DERMATITIS Medicina v Kuzbasse атопический дерматит цитокины «кожное окно» актг |
| title | ACTH-CYTOKINE ASSOCIATIONS IN THE «SKIN WINDOW» EXUDATES IN ATOPIC DERMATITIS |
| title_full | ACTH-CYTOKINE ASSOCIATIONS IN THE «SKIN WINDOW» EXUDATES IN ATOPIC DERMATITIS |
| title_fullStr | ACTH-CYTOKINE ASSOCIATIONS IN THE «SKIN WINDOW» EXUDATES IN ATOPIC DERMATITIS |
| title_full_unstemmed | ACTH-CYTOKINE ASSOCIATIONS IN THE «SKIN WINDOW» EXUDATES IN ATOPIC DERMATITIS |
| title_short | ACTH-CYTOKINE ASSOCIATIONS IN THE «SKIN WINDOW» EXUDATES IN ATOPIC DERMATITIS |
| title_sort | acth cytokine associations in the skin window exudates in atopic dermatitis |
| topic | атопический дерматит цитокины «кожное окно» актг |
| url | https://mednauki.ru/index.php/MK/article/view/997 |
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