Vascular Calcification in Chronic Kidney Disease Patients- A Cross-sectional Study
Introduction: Vascular Calcification (VC) is considered as a cardiovascular risk marker in Chronic Kidney Disease (CKD) patients. VC is a process characterised by thickening and loss of elasticity of muscular arteries walls. The three pathological forms of cardiovascular disease in CKD are cardiac g...
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JCDR Research and Publications Private Limited
2022-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/16182/52601_CE[Ra1]_F[SH]_PF1(SC_KM)_PFA(KM)_PN(SHU).pdf |
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| author | M Bagavad Geetha R Logesh M Jayakumar S Santhosh Santhi Silambanan Viji Devanand |
| author_facet | M Bagavad Geetha R Logesh M Jayakumar S Santhosh Santhi Silambanan Viji Devanand |
| author_sort | M Bagavad Geetha |
| collection | DOAJ |
| description | Introduction: Vascular Calcification (VC) is considered as a cardiovascular risk marker in Chronic Kidney Disease (CKD) patients. VC is a process characterised by thickening and loss of elasticity of muscular arteries walls. The three pathological forms of cardiovascular disease in CKD are cardiac geometry, atherosclerosis and arteriosclerosis of the large vessels (carotid artery or aorta).
Aim: To evaluate VC as a cardiovascular risk marker in CKD patients.
Materials and Methods: This cross-sectional study was conducted in the Nephrology Department at Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India, from November 2019-December 2020. The study included 27 CKD patients who were on maintenance haemodialysis. The participants were 20-70 years of age, and of both genders. The Intima Media Thickness (IMT) was assessed by ultrasonography. Peak Systolic Velocity (PSV) measurement was done using doppler ultrasonography. Both the measurements were done on Common Carotid Artery (CCA), and Internal Carotid Artery (ICA) on both sides of the neck. Student’s t-test and Chi-square test was used in this study. Data were expressed as mean±SD. The p-value <0.05 was considered as statistically significant.
Results: Out of 27 study participants, 20 (74%) were male and females were 7 (26%), with mean age of 48 years. There was significant increase in IMT of the ICA on the right side of the neck compared to left side (p-value=0.01). Also, there was significant increase in PSV of ICA on the right side compared to left side of the neck (p-value=0.04). There were no statistically significant differences in IMT and PSV when CCA on the right side was compared to that of the left side of the neck.
Conclusion: The IMT was increased in ICA and CCA. But there was statistically significant difference only in ICA, where it was more prominent on the right side compared to left side. CKD patients on haemodialysis management could have the risk factors in the form of increased IMT predisposing them to early mortality from cardiovascular complications. |
| first_indexed | 2024-04-10T16:40:55Z |
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| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T16:40:55Z |
| publishDate | 2022-04-01 |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-3c39aaa168d64f24b1931b17a9342ec02023-02-08T07:15:21ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2022-04-01164CC01CC0310.7860/JCDR/2022/52601.16182Vascular Calcification in Chronic Kidney Disease Patients- A Cross-sectional StudyM Bagavad Geetha0R Logesh1M Jayakumar2S Santhosh3Santhi Silambanan4Viji Devanand5Professor, Department of Physiology, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, Tamil Nadu, India.Assistant Professor, Department of Radiology, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, Tamil Nadu, India.Professor, Department of Nephrology, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, Tamil Nadu, India.PhD Student, Department of Anatomy, Chettinad Medical College and Research Institute, Kancheepuram, Chennai, Tamil Nadu, India.Professor, Department of Biochemistry, Sri Ramachandra Institue of Higher Education and Research, Porur, Chennai, Tamil Nadu, India.Professor, Department of Physiology, Stanley Medical College, Chennai, Tamil Nadu, India.Introduction: Vascular Calcification (VC) is considered as a cardiovascular risk marker in Chronic Kidney Disease (CKD) patients. VC is a process characterised by thickening and loss of elasticity of muscular arteries walls. The three pathological forms of cardiovascular disease in CKD are cardiac geometry, atherosclerosis and arteriosclerosis of the large vessels (carotid artery or aorta). Aim: To evaluate VC as a cardiovascular risk marker in CKD patients. Materials and Methods: This cross-sectional study was conducted in the Nephrology Department at Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India, from November 2019-December 2020. The study included 27 CKD patients who were on maintenance haemodialysis. The participants were 20-70 years of age, and of both genders. The Intima Media Thickness (IMT) was assessed by ultrasonography. Peak Systolic Velocity (PSV) measurement was done using doppler ultrasonography. Both the measurements were done on Common Carotid Artery (CCA), and Internal Carotid Artery (ICA) on both sides of the neck. Student’s t-test and Chi-square test was used in this study. Data were expressed as mean±SD. The p-value <0.05 was considered as statistically significant. Results: Out of 27 study participants, 20 (74%) were male and females were 7 (26%), with mean age of 48 years. There was significant increase in IMT of the ICA on the right side of the neck compared to left side (p-value=0.01). Also, there was significant increase in PSV of ICA on the right side compared to left side of the neck (p-value=0.04). There were no statistically significant differences in IMT and PSV when CCA on the right side was compared to that of the left side of the neck. Conclusion: The IMT was increased in ICA and CCA. But there was statistically significant difference only in ICA, where it was more prominent on the right side compared to left side. CKD patients on haemodialysis management could have the risk factors in the form of increased IMT predisposing them to early mortality from cardiovascular complications.https://www.jcdr.net/articles/PDF/16182/52601_CE[Ra1]_F[SH]_PF1(SC_KM)_PFA(KM)_PN(SHU).pdfcarotid arteryintima media thicknessultrasonography |
| spellingShingle | M Bagavad Geetha R Logesh M Jayakumar S Santhosh Santhi Silambanan Viji Devanand Vascular Calcification in Chronic Kidney Disease Patients- A Cross-sectional Study Journal of Clinical and Diagnostic Research carotid artery intima media thickness ultrasonography |
| title | Vascular Calcification in Chronic Kidney Disease Patients- A Cross-sectional Study |
| title_full | Vascular Calcification in Chronic Kidney Disease Patients- A Cross-sectional Study |
| title_fullStr | Vascular Calcification in Chronic Kidney Disease Patients- A Cross-sectional Study |
| title_full_unstemmed | Vascular Calcification in Chronic Kidney Disease Patients- A Cross-sectional Study |
| title_short | Vascular Calcification in Chronic Kidney Disease Patients- A Cross-sectional Study |
| title_sort | vascular calcification in chronic kidney disease patients a cross sectional study |
| topic | carotid artery intima media thickness ultrasonography |
| url | https://www.jcdr.net/articles/PDF/16182/52601_CE[Ra1]_F[SH]_PF1(SC_KM)_PFA(KM)_PN(SHU).pdf |
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