Development of an Acid-Labile Ketal Linked Amphiphilic Block Copolymer Nanoparticles for pH-Triggered Release of Paclitaxel

Development of an Acid-Labile Ketal Linked Amphiphilic Block Copolymer Nanoparticles for pH-Triggered Release of Paclitaxel

Here, we report on the construction of biodegradable poly(ethylene oxide monomethyl ether) (MPEO)-<i>b</i>-poly(ε-caprolactone) (PCL) nanoparticles (NPs) having acid-labile (acyclic ketal group) linkage at the block junction. In the presence of acidic pH, the nanoassemblies were destabil...

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Bibliographic Details
Main Authors: Svetlana Lukáš Petrova, Eliézer Jäger, Alessandro Jäger, Anita Höcherl, Rafał Konefał, Alexander Zhigunov, Ewa Pavlova, Olga Janoušková, Martin Hrubý
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Polymers
Subjects:
MPEO-<i>b</i>-PCL nanoparticles
acyclic ketal group
paclitaxel
human HeLa carcinoma cells
Online Access:https://www.mdpi.com/2073-4360/13/9/1465

Internet

https://www.mdpi.com/2073-4360/13/9/1465

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