Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health
Abstract Despite knowledge the gut microbiota regulates bone mass, mechanisms governing the normal gut microbiota’s osteoimmunomodulatory effects on skeletal remodeling and homeostasis are unclear in the healthy adult skeleton. Young adult specific-pathogen-free and germ-free mice were used to delin...
Main Authors: | Chad M. Novince, Carolyn R. Whittow, Johannes D. Aartun, Jessica D. Hathaway, Nicole Poulides, Michael B. Chavez, Heidi M. Steinkamp, Kaeleigh A. Kirkwood, Emily Huang, Caroline Westwater, Keith L. Kirkwood |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2017-07-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-017-06126-x |
Similar Items
-
Commensal Microbiota Effects on Craniofacial Skeletal Growth and Morphology
by: Joy E. Gerasco, et al.
Published: (2023-08-01) -
Commensal oral microbiota induces osteoimmunomodulatory effects separate from systemic microbiome in mice
by: Jessica D. Hathaway-Schrader, et al.
Published: (2022-02-01) -
GPR65, a novel regulator of helper T‐cell polarization in inflammatory bowel disease
by: Jessica D. Hathaway‐Schrader, et al.
Published: (2022-06-01) -
The commensal microbiota drives immune homeostasis
by: Marie-Claire eArrieta, et al.
Published: (2012-03-01) -
C3a-C3aR signaling is a novel modulator of skeletal homeostasis
by: Megan B. Kuhn, et al.
Published: (2023-06-01)