Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection
Ageing has been associated with impaired function of alveolar macrophages and increased susceptibility, mortality and complications as a result of viral infection. Here, the authors show that prostaglandin E2 is one of the factors responsible for impairing immune defences against influenza during ag...
Main Authors: | Judy Chen, Jane C. Deng, Rachel L. Zemans, Karim Bahmed, Beata Kosmider, Min Zhang, Marc Peters-Golden, Daniel R. Goldstein |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-11-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-34593-y |
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