Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response
Summary: Severe infections with coronaviruses are often accompanied with hyperinflammation, requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By screening a safe-in-human broad-spectrum antiviral agents library, we identified that indomethacin can inhibit pan-coro...
Main Authors: | Yining Wang, Pengfei Li, Lei Xu, Annemarie C. de Vries, Robbert J. Rottier, Wenshi Wang, Marie-Rose B.S. Crombag, Maikel P. Peppelenbosch, Denis E. Kainov, Qiuwei Pan |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-09-01
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Series: | iScience |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422301708X |
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