Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced Scleroderma
Scleroderma is an autoimmune disease caused by the abnormal regulation of extracellular matrix synthesis and is activated by non-regulated inflammatory cells and cytokines. Echinochrome A (EchA), a natural pigment isolated from sea urchins, has been demonstrated to have antioxidant activities and be...
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MDPI AG
2021-04-01
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| Series: | Marine Drugs |
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| author | Gyu-Tae Park Jung-Won Yoon Sang-Bin Yoo Young-Chul Song Parkyong Song Hyoung-Kyu Kim Jin Han Sung-Jin Bae Ki-Tae Ha Natalia P. Mishchenko Sergey A. Fedoreyev Valentin A. Stonik Moon-Bum Kim Jae-Ho Kim |
| author_facet | Gyu-Tae Park Jung-Won Yoon Sang-Bin Yoo Young-Chul Song Parkyong Song Hyoung-Kyu Kim Jin Han Sung-Jin Bae Ki-Tae Ha Natalia P. Mishchenko Sergey A. Fedoreyev Valentin A. Stonik Moon-Bum Kim Jae-Ho Kim |
| author_sort | Gyu-Tae Park |
| collection | DOAJ |
| description | Scleroderma is an autoimmune disease caused by the abnormal regulation of extracellular matrix synthesis and is activated by non-regulated inflammatory cells and cytokines. Echinochrome A (EchA), a natural pigment isolated from sea urchins, has been demonstrated to have antioxidant activities and beneficial effects in various disease models. The present study demonstrates for the first time that EchA treatment alleviates bleomycin-induced scleroderma by normalizing dermal thickness and suppressing collagen deposition in vivo. EchA treatment reduces the number of activated myofibroblasts expressing α-SMA, vimentin, and phosphorylated Smad3 in bleomycin-induced scleroderma. In addition, it decreased the number of macrophages, including M1 and M2 types in the affected skin, suggesting the induction of an anti-inflammatory effect. Furthermore, EchA treatment markedly attenuated serum levels of inflammatory cytokines, such as tumor necrosis factor-α and interferon-γ, in a murine scleroderma model. Taken together, these results suggest that EchA is highly useful for the treatment of scleroderma, exerting anti-fibrosis and anti-inflammatory effects. |
| first_indexed | 2024-03-10T12:03:37Z |
| format | Article |
| id | doaj.art-3c453084af4847738cc4d3c438a3ddaf |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T12:03:37Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-3c453084af4847738cc4d3c438a3ddaf2023-11-21T16:46:16ZengMDPI AGMarine Drugs1660-33972021-04-0119523710.3390/md19050237Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced SclerodermaGyu-Tae Park0Jung-Won Yoon1Sang-Bin Yoo2Young-Chul Song3Parkyong Song4Hyoung-Kyu Kim5Jin Han6Sung-Jin Bae7Ki-Tae Ha8Natalia P. Mishchenko9Sergey A. Fedoreyev10Valentin A. Stonik11Moon-Bum Kim12Jae-Ho Kim13Department of Physiology, Pusan National University School of Medicine, Yangsan 50612, KoreaDepartment of Physiology, Pusan National University School of Medicine, Yangsan 50612, KoreaDepartment of Physiology, Pusan National University School of Medicine, Yangsan 50612, KoreaDepartment of Physiology, Pusan National University School of Medicine, Yangsan 50612, KoreaDepartment of Convergence Medicine, Pusan National University School of Medicine, Yangsan 50612, KoreaNational Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center (CMDC), Inje University, Busan 47392, KoreaNational Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center (CMDC), Inje University, Busan 47392, KoreaHealthy Aging Korean Medical Research Center, Pusan National University, Yangsan 50612, KoreaDepartment of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan 50612, KoreaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, RussiaDepartment of Dermatology, Pusan National University School of Medicine, Yangsan 50612, KoreaDepartment of Physiology, Pusan National University School of Medicine, Yangsan 50612, KoreaScleroderma is an autoimmune disease caused by the abnormal regulation of extracellular matrix synthesis and is activated by non-regulated inflammatory cells and cytokines. Echinochrome A (EchA), a natural pigment isolated from sea urchins, has been demonstrated to have antioxidant activities and beneficial effects in various disease models. The present study demonstrates for the first time that EchA treatment alleviates bleomycin-induced scleroderma by normalizing dermal thickness and suppressing collagen deposition in vivo. EchA treatment reduces the number of activated myofibroblasts expressing α-SMA, vimentin, and phosphorylated Smad3 in bleomycin-induced scleroderma. In addition, it decreased the number of macrophages, including M1 and M2 types in the affected skin, suggesting the induction of an anti-inflammatory effect. Furthermore, EchA treatment markedly attenuated serum levels of inflammatory cytokines, such as tumor necrosis factor-α and interferon-γ, in a murine scleroderma model. Taken together, these results suggest that EchA is highly useful for the treatment of scleroderma, exerting anti-fibrosis and anti-inflammatory effects.https://www.mdpi.com/1660-3397/19/5/237echinochrome Asclerodermainflammationfibrosissystemic sclerosis |
| spellingShingle | Gyu-Tae Park Jung-Won Yoon Sang-Bin Yoo Young-Chul Song Parkyong Song Hyoung-Kyu Kim Jin Han Sung-Jin Bae Ki-Tae Ha Natalia P. Mishchenko Sergey A. Fedoreyev Valentin A. Stonik Moon-Bum Kim Jae-Ho Kim Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced Scleroderma Marine Drugs echinochrome A scleroderma inflammation fibrosis systemic sclerosis |
| title | Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced Scleroderma |
| title_full | Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced Scleroderma |
| title_fullStr | Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced Scleroderma |
| title_full_unstemmed | Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced Scleroderma |
| title_short | Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced Scleroderma |
| title_sort | echinochrome a treatment alleviates fibrosis and inflammation in bleomycin induced scleroderma |
| topic | echinochrome A scleroderma inflammation fibrosis systemic sclerosis |
| url | https://www.mdpi.com/1660-3397/19/5/237 |
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