In Vitro Sensitive Skin Models: Review of the Standard Methods and Introduction to a New Disruptive Technology
The skin is a protective organ, able to decode a wide range of tactile, thermal, or noxious stimuli. Some of the sensors belonging to the transient receptor potential (TRP) family, for example, TRPV1, can elicit capsaicin-induced heat pain or histamine-induced itching sensations. The sensory nerve f...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
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| Series: | Cosmetics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-9284/9/4/67 |
| _version_ | 1797410747347632128 |
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| author | Alexandre Guichard Noëlle Remoué Thibault Honegger |
| author_facet | Alexandre Guichard Noëlle Remoué Thibault Honegger |
| author_sort | Alexandre Guichard |
| collection | DOAJ |
| description | The skin is a protective organ, able to decode a wide range of tactile, thermal, or noxious stimuli. Some of the sensors belonging to the transient receptor potential (TRP) family, for example, TRPV1, can elicit capsaicin-induced heat pain or histamine-induced itching sensations. The sensory nerve fibers, whose soma is located in the trigeminal or the dorsal root ganglia, are able to carry signals from the skin’s sensory receptors toward the brain via the spinal cord. In some cases, in response to environmental factors, nerve endings might be hyper activated, leading to a sensitive skin syndrome (SSS). SSS affects about 50% of the population and is correlated with small-fiber neuropathies resulting in neuropathic pain. Thus, for cosmetical and pharmaceutical industries developing SSS treatments, the selection of relevant and predictive in vitro models is essential. In this article, we reviewed the different in vitro models developed for the assessment of skin and neuron interactions. In a second part, we presented the advantages of microfluidic devices and organ-on-chip models, with a focus on the first model we developed in this context. |
| first_indexed | 2024-03-09T04:34:41Z |
| format | Article |
| id | doaj.art-3c49578051004da8a4ca36482eff8e19 |
| institution | Directory Open Access Journal |
| issn | 2079-9284 |
| language | English |
| last_indexed | 2024-03-09T04:34:41Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj.art-3c49578051004da8a4ca36482eff8e192023-12-03T13:29:30ZengMDPI AGCosmetics2079-92842022-06-01946710.3390/cosmetics9040067In Vitro Sensitive Skin Models: Review of the Standard Methods and Introduction to a New Disruptive TechnologyAlexandre Guichard0Noëlle Remoué1Thibault Honegger2NETRI, 69007 Lyon, FranceNETRI, 69007 Lyon, FranceNETRI, 69007 Lyon, FranceThe skin is a protective organ, able to decode a wide range of tactile, thermal, or noxious stimuli. Some of the sensors belonging to the transient receptor potential (TRP) family, for example, TRPV1, can elicit capsaicin-induced heat pain or histamine-induced itching sensations. The sensory nerve fibers, whose soma is located in the trigeminal or the dorsal root ganglia, are able to carry signals from the skin’s sensory receptors toward the brain via the spinal cord. In some cases, in response to environmental factors, nerve endings might be hyper activated, leading to a sensitive skin syndrome (SSS). SSS affects about 50% of the population and is correlated with small-fiber neuropathies resulting in neuropathic pain. Thus, for cosmetical and pharmaceutical industries developing SSS treatments, the selection of relevant and predictive in vitro models is essential. In this article, we reviewed the different in vitro models developed for the assessment of skin and neuron interactions. In a second part, we presented the advantages of microfluidic devices and organ-on-chip models, with a focus on the first model we developed in this context.https://www.mdpi.com/2079-9284/9/4/67neuronskinsensitive skinorgan-on-chipmicrofluidic deviceTRPV |
| spellingShingle | Alexandre Guichard Noëlle Remoué Thibault Honegger In Vitro Sensitive Skin Models: Review of the Standard Methods and Introduction to a New Disruptive Technology Cosmetics neuron skin sensitive skin organ-on-chip microfluidic device TRPV |
| title | In Vitro Sensitive Skin Models: Review of the Standard Methods and Introduction to a New Disruptive Technology |
| title_full | In Vitro Sensitive Skin Models: Review of the Standard Methods and Introduction to a New Disruptive Technology |
| title_fullStr | In Vitro Sensitive Skin Models: Review of the Standard Methods and Introduction to a New Disruptive Technology |
| title_full_unstemmed | In Vitro Sensitive Skin Models: Review of the Standard Methods and Introduction to a New Disruptive Technology |
| title_short | In Vitro Sensitive Skin Models: Review of the Standard Methods and Introduction to a New Disruptive Technology |
| title_sort | in vitro sensitive skin models review of the standard methods and introduction to a new disruptive technology |
| topic | neuron skin sensitive skin organ-on-chip microfluidic device TRPV |
| url | https://www.mdpi.com/2079-9284/9/4/67 |
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