Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination
Background: The frequent association of basilar invagination (BI) makes the understanding of the pathogenesis of Chiari malformation type I (CMI) difficult. The influence of group B type of BI (the BI without obvious atlantoaxial instability) on the skeletal morphology has not been thoroughly studie...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2022-03-01
|
| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/JIN/21/2/10.31083/j.jin2102070 |
| _version_ | 1818041213665673216 |
|---|---|
| author | Yongzhi Xia Haijian Xia Wei Tang Shengxi Wang Yi Yan |
| author_facet | Yongzhi Xia Haijian Xia Wei Tang Shengxi Wang Yi Yan |
| author_sort | Yongzhi Xia |
| collection | DOAJ |
| description | Background: The frequent association of basilar invagination (BI) makes the understanding of the pathogenesis of Chiari malformation type I (CMI) difficult. The influence of group B type of BI (the BI without obvious atlantoaxial instability) on the skeletal morphology has not been thoroughly studied. The objective of this study is to evaluate the skeletal alterations in the posterior cranial fossa (PCF) of adult CMI cases with and without group B BI. Methods: Fifty-four adult CMI without BI cases (CMI-only group) and 30 adult CMI with group B BI cases (CMI-BI group) were retrospectively studied. Fifty-six adult patients with unruptured intracranial aneurysms were included as the controls. Several linear and angular variables, and the bony volume of the PCF were analyzed based on thin-slice computed tomography data. Results: Morphological analysis revealed a significant difference in several variables from controls compared to CMI-only, and CMI-BI patients. The clivus and occipital bone, shortened and elevated in CMI-only patients, were further flattened in BI-associated CMI patients. Furthermore, although out of the scope for the diagnostic threshold of BI, the CMI-only cases also had a tendency to form BI. The association of BI modified several variables, without further reducing the bony PCF volume. Conclusions: These findings indicate that the variables associated with group B BI tend to be a continuum of the same pathological abnormalities that originate from the same pathological alterations in CMI patients. |
| first_indexed | 2024-12-10T08:26:51Z |
| format | Article |
| id | doaj.art-3c4d4451cc06421ea649947f850053e7 |
| institution | Directory Open Access Journal |
| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-12-10T08:26:51Z |
| publishDate | 2022-03-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-3c4d4451cc06421ea649947f850053e72022-12-22T01:56:12ZengIMR PressJournal of Integrative Neuroscience0219-63522022-03-0121207010.31083/j.jin2102070S0219-6352(22)00330-8Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invaginationYongzhi Xia0Haijian Xia1Wei Tang2Shengxi Wang3Yi Yan4Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, 400016 Yuzhong District, Chongqing, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, 400016 Yuzhong District, Chongqing, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, 400016 Yuzhong District, Chongqing, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, 400016 Yuzhong District, Chongqing, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, 400016 Yuzhong District, Chongqing, ChinaBackground: The frequent association of basilar invagination (BI) makes the understanding of the pathogenesis of Chiari malformation type I (CMI) difficult. The influence of group B type of BI (the BI without obvious atlantoaxial instability) on the skeletal morphology has not been thoroughly studied. The objective of this study is to evaluate the skeletal alterations in the posterior cranial fossa (PCF) of adult CMI cases with and without group B BI. Methods: Fifty-four adult CMI without BI cases (CMI-only group) and 30 adult CMI with group B BI cases (CMI-BI group) were retrospectively studied. Fifty-six adult patients with unruptured intracranial aneurysms were included as the controls. Several linear and angular variables, and the bony volume of the PCF were analyzed based on thin-slice computed tomography data. Results: Morphological analysis revealed a significant difference in several variables from controls compared to CMI-only, and CMI-BI patients. The clivus and occipital bone, shortened and elevated in CMI-only patients, were further flattened in BI-associated CMI patients. Furthermore, although out of the scope for the diagnostic threshold of BI, the CMI-only cases also had a tendency to form BI. The association of BI modified several variables, without further reducing the bony PCF volume. Conclusions: These findings indicate that the variables associated with group B BI tend to be a continuum of the same pathological abnormalities that originate from the same pathological alterations in CMI patients.https://www.imrpress.com/journal/JIN/21/2/10.31083/j.jin2102070basilar invaginationchiari malformation type icomputer tomographyforamen magnum decompressionposterior cranial fossa |
| spellingShingle | Yongzhi Xia Haijian Xia Wei Tang Shengxi Wang Yi Yan Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination Journal of Integrative Neuroscience basilar invagination chiari malformation type i computer tomography foramen magnum decompression posterior cranial fossa |
| title | Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination |
| title_full | Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination |
| title_fullStr | Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination |
| title_full_unstemmed | Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination |
| title_short | Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination |
| title_sort | morphometric and volumetric analysis of the posterior cranial fossa in adult chiari malformation type i with and without group b basilar invagination |
| topic | basilar invagination chiari malformation type i computer tomography foramen magnum decompression posterior cranial fossa |
| url | https://www.imrpress.com/journal/JIN/21/2/10.31083/j.jin2102070 |
| work_keys_str_mv | AT yongzhixia morphometricandvolumetricanalysisoftheposteriorcranialfossainadultchiarimalformationtypeiwithandwithoutgroupbbasilarinvagination AT haijianxia morphometricandvolumetricanalysisoftheposteriorcranialfossainadultchiarimalformationtypeiwithandwithoutgroupbbasilarinvagination AT weitang morphometricandvolumetricanalysisoftheposteriorcranialfossainadultchiarimalformationtypeiwithandwithoutgroupbbasilarinvagination AT shengxiwang morphometricandvolumetricanalysisoftheposteriorcranialfossainadultchiarimalformationtypeiwithandwithoutgroupbbasilarinvagination AT yiyan morphometricandvolumetricanalysisoftheposteriorcranialfossainadultchiarimalformationtypeiwithandwithoutgroupbbasilarinvagination |