Influence of Metabolic Syndrome on Cancer Risk in HBV Carriers: A Nationwide Population Based Study Using the National Health Insurance Service Database
Purpose: Hepatitis B virus (HBV) infection and metabolic syndrome (MS) are known independent risk factors for hepatocellular carcinoma (HCC) and other extrahepatic organ malignancies. The purpose of this study was to investigate whether MS and HBV have synergistic effects on cancers and to examine w...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/11/2401 |
| _version_ | 1797532112030531584 |
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| author | Jung Wan Choe Jong Jin Hyun Bongseong Kim Kyung-Do Han |
| author_facet | Jung Wan Choe Jong Jin Hyun Bongseong Kim Kyung-Do Han |
| author_sort | Jung Wan Choe |
| collection | DOAJ |
| description | Purpose: Hepatitis B virus (HBV) infection and metabolic syndrome (MS) are known independent risk factors for hepatocellular carcinoma (HCC) and other extrahepatic organ malignancies. The purpose of this study was to investigate whether MS and HBV have synergistic effects on cancers and to examine whether increasing the number of MS components could lead to higher risk of cancer development. Materials and Methods: We evaluated data from 1,504,880 HBV-infected adults who underwent a regular HCC screening program provided by the Korean National Health Insurance Service between 2009 and 2016. Results: The prevalence of MS in Korean HBV patients was 38.7% (582,449/1,504,880). Among individuals with HBV infection, the presence of MS was associated with an increased risk for the majority of malignancies except for HCC (HR = 0.862, <i>p</i>-value < 0.05). The presence of a higher number of MS components was associated with a significantly increased risk of developing cancers in most organs; only HCC was negatively associated with an increasing number of MS components (<i>p</i> < 0.01). Conclusions: Our data show that the presence of MS increases the risk for most malignancies, excluding HCC. Moreover, we found that as the number of MS components increased, the risk for most cancers also increased; this trend was reversed in HCC. |
| first_indexed | 2024-03-10T10:54:28Z |
| format | Article |
| id | doaj.art-3c4db2c3f2c64d7f9f0a77c7ed748a3a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T10:54:28Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3c4db2c3f2c64d7f9f0a77c7ed748a3a2023-11-21T21:56:55ZengMDPI AGJournal of Clinical Medicine2077-03832021-05-011011240110.3390/jcm10112401Influence of Metabolic Syndrome on Cancer Risk in HBV Carriers: A Nationwide Population Based Study Using the National Health Insurance Service DatabaseJung Wan Choe0Jong Jin Hyun1Bongseong Kim2Kyung-Do Han3Department of Internal Medicine, Korea University Ansan Hospital, Ansan 15355, KoreaDepartment of Internal Medicine, Korea University Ansan Hospital, Ansan 15355, KoreaDepartment of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaPurpose: Hepatitis B virus (HBV) infection and metabolic syndrome (MS) are known independent risk factors for hepatocellular carcinoma (HCC) and other extrahepatic organ malignancies. The purpose of this study was to investigate whether MS and HBV have synergistic effects on cancers and to examine whether increasing the number of MS components could lead to higher risk of cancer development. Materials and Methods: We evaluated data from 1,504,880 HBV-infected adults who underwent a regular HCC screening program provided by the Korean National Health Insurance Service between 2009 and 2016. Results: The prevalence of MS in Korean HBV patients was 38.7% (582,449/1,504,880). Among individuals with HBV infection, the presence of MS was associated with an increased risk for the majority of malignancies except for HCC (HR = 0.862, <i>p</i>-value < 0.05). The presence of a higher number of MS components was associated with a significantly increased risk of developing cancers in most organs; only HCC was negatively associated with an increasing number of MS components (<i>p</i> < 0.01). Conclusions: Our data show that the presence of MS increases the risk for most malignancies, excluding HCC. Moreover, we found that as the number of MS components increased, the risk for most cancers also increased; this trend was reversed in HCC.https://www.mdpi.com/2077-0383/10/11/2401metabolic syndromehepatitis B virusneoplasms |
| spellingShingle | Jung Wan Choe Jong Jin Hyun Bongseong Kim Kyung-Do Han Influence of Metabolic Syndrome on Cancer Risk in HBV Carriers: A Nationwide Population Based Study Using the National Health Insurance Service Database Journal of Clinical Medicine metabolic syndrome hepatitis B virus neoplasms |
| title | Influence of Metabolic Syndrome on Cancer Risk in HBV Carriers: A Nationwide Population Based Study Using the National Health Insurance Service Database |
| title_full | Influence of Metabolic Syndrome on Cancer Risk in HBV Carriers: A Nationwide Population Based Study Using the National Health Insurance Service Database |
| title_fullStr | Influence of Metabolic Syndrome on Cancer Risk in HBV Carriers: A Nationwide Population Based Study Using the National Health Insurance Service Database |
| title_full_unstemmed | Influence of Metabolic Syndrome on Cancer Risk in HBV Carriers: A Nationwide Population Based Study Using the National Health Insurance Service Database |
| title_short | Influence of Metabolic Syndrome on Cancer Risk in HBV Carriers: A Nationwide Population Based Study Using the National Health Insurance Service Database |
| title_sort | influence of metabolic syndrome on cancer risk in hbv carriers a nationwide population based study using the national health insurance service database |
| topic | metabolic syndrome hepatitis B virus neoplasms |
| url | https://www.mdpi.com/2077-0383/10/11/2401 |
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