Intervillous macrophage migration inhibitory factor is associated with adverse birth outcomes in a study population in Central India.
Macrophage migration inhibitory factor (MIF) is a pluripotent factor produced by a variety of cells. It plays an important biological role in the regulation of pregnancy and has been shown to influence malaria pathogenesis. In this study, the levels of MIF in the peripheral, cord and placental inter...
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3521649?pdf=render |
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| author | Puspendra P Singh Naomi W Lucchi Anna Blackstock Venkatachalam Udhayakumar Neeru Singh |
| author_facet | Puspendra P Singh Naomi W Lucchi Anna Blackstock Venkatachalam Udhayakumar Neeru Singh |
| author_sort | Puspendra P Singh |
| collection | DOAJ |
| description | Macrophage migration inhibitory factor (MIF) is a pluripotent factor produced by a variety of cells. It plays an important biological role in the regulation of pregnancy and has been shown to influence malaria pathogenesis. In this study, the levels of MIF in the peripheral, cord and placental intervillous blood (IVB) plasma collected from women residing in a malaria endemic region of Central India was determined and its association with malaria in pregnancy and birth outcomes was investigated. MIF levels were significantly different in IVB, peripheral, and cord plasma, with IVB plasma having the highest MIF levels and peripheral plasma having the lowest. Placental malaria positive women had significantly higher IVB plasma MIF levels than placental malaria negative women, but this relationship was not seen in peripheral or cord plasma MIF levels. In addition, the odds of stillbirth and low birth weight deliveries for the uppermost placental MIF quartile (irrespective of placental malaria status) was significantly higher than that of the lowest placental MIF quartile, supporting the hypothesis that elevated concentrations of placental MIF may be associated with an increased risk of adverse birth outcome. |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T22:03:25Z |
| publishDate | 2012-01-01 |
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| spelling | doaj.art-3c50869e21ae48e581dc504d10dba5eb2022-12-21T22:14:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5167810.1371/journal.pone.0051678Intervillous macrophage migration inhibitory factor is associated with adverse birth outcomes in a study population in Central India.Puspendra P SinghNaomi W LucchiAnna BlackstockVenkatachalam UdhayakumarNeeru SinghMacrophage migration inhibitory factor (MIF) is a pluripotent factor produced by a variety of cells. It plays an important biological role in the regulation of pregnancy and has been shown to influence malaria pathogenesis. In this study, the levels of MIF in the peripheral, cord and placental intervillous blood (IVB) plasma collected from women residing in a malaria endemic region of Central India was determined and its association with malaria in pregnancy and birth outcomes was investigated. MIF levels were significantly different in IVB, peripheral, and cord plasma, with IVB plasma having the highest MIF levels and peripheral plasma having the lowest. Placental malaria positive women had significantly higher IVB plasma MIF levels than placental malaria negative women, but this relationship was not seen in peripheral or cord plasma MIF levels. In addition, the odds of stillbirth and low birth weight deliveries for the uppermost placental MIF quartile (irrespective of placental malaria status) was significantly higher than that of the lowest placental MIF quartile, supporting the hypothesis that elevated concentrations of placental MIF may be associated with an increased risk of adverse birth outcome.http://europepmc.org/articles/PMC3521649?pdf=render |
| spellingShingle | Puspendra P Singh Naomi W Lucchi Anna Blackstock Venkatachalam Udhayakumar Neeru Singh Intervillous macrophage migration inhibitory factor is associated with adverse birth outcomes in a study population in Central India. PLoS ONE |
| title | Intervillous macrophage migration inhibitory factor is associated with adverse birth outcomes in a study population in Central India. |
| title_full | Intervillous macrophage migration inhibitory factor is associated with adverse birth outcomes in a study population in Central India. |
| title_fullStr | Intervillous macrophage migration inhibitory factor is associated with adverse birth outcomes in a study population in Central India. |
| title_full_unstemmed | Intervillous macrophage migration inhibitory factor is associated with adverse birth outcomes in a study population in Central India. |
| title_short | Intervillous macrophage migration inhibitory factor is associated with adverse birth outcomes in a study population in Central India. |
| title_sort | intervillous macrophage migration inhibitory factor is associated with adverse birth outcomes in a study population in central india |
| url | http://europepmc.org/articles/PMC3521649?pdf=render |
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