Genetic Deletion of P2Y2 Receptor Offers Long-Term (5 Months) Protection Against Lithium-Induced Polyuria, Natriuresis, Kaliuresis, and Collecting Duct Remodeling and Cell Proliferation

Genetic Deletion of P2Y2 Receptor Offers Long-Term (5 Months) Protection Against Lithium-Induced Polyuria, Natriuresis, Kaliuresis, and Collecting Duct Remodeling and Cell Proliferation

Chronic lithium administration for the treatment of bipolar disorder leads to nephrogenic diabetes insipidus (NDI), characterized by polyuria, natriuresis, kaliuresis, and collecting duct remodeling and cell proliferation among other features. Previously, using a 2-week lithium-induced NDI model, we...

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Bibliographic Details
Main Authors: Yue Zhang, Anne Riquier-Brison, Tao Liu, Yufeng Huang, Noel G. Carlson, János Peti-Peterdi, Bellamkonda K. Kishore
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Physiology
Subjects:
diabetes insipidus
polyuria
natriuresis
kaliuresis
collecting duct remodeling
cell proliferation
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01765/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01765/full

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