Non-invasive Assessment of Subclinical Renal Parenchymal Changes in Chronic Hepatitis B Virus By T1 Mapping Magnetic Resonance Imaging
Background: Renal parenchymal changes are seen in chronic hepatitis B virus (HBV) infection, and its disease diagnosis should be confirmed by renal biopsy, which is an invasive technique. Apparent-T1 mapping magnetic resonance imaging (MRI) is an established imaging technique that assesses subclinic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2022-03-01
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| Series: | Balkan Medical Journal |
| Online Access: | https://balkanmedicaljournal.org/text.php?lang=en&id=2381 |
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| author | Serçin Özkök Ayşenur Buz Servet Erdemli Gülşah Şaşak Kuzgun Ahmet Aslan |
| author_facet | Serçin Özkök Ayşenur Buz Servet Erdemli Gülşah Şaşak Kuzgun Ahmet Aslan |
| author_sort | Serçin Özkök |
| collection | DOAJ |
| description | Background: Renal parenchymal changes are seen in chronic hepatitis B virus (HBV) infection, and its disease diagnosis should be confirmed by renal biopsy, which is an invasive technique. Apparent-T1 mapping magnetic resonance imaging (MRI) is an established imaging technique that assesses subclinical tissue injury without using a contrast agent.
Aims: To investigate the early stage subclinical renal changes without apparent renal dysfunction in patients with chronic HBV infection by renal apparent-T1 mapping MRI.
Study Design: A cross-sectional study.
Methods: This study included 45 participants with normal kidney function, wherein 25 have biopsy-proven chronic HBV hepatitis and 20 are healthy individuals. Liver and kidney biochemical tests were performed within 1 month before the MRI scan, and the estimated glomerular filtration rate was calculated by diet modification in renal disease formula. Breath-hold, electrocardiogram-gated Modified Look-Locker Imaging sequence was acquired in the coronal plane without contrast agent administration. Apparent-T1 mapping value was measured by manually drawing a region of interest in six points for both kidneys by two observers. Apparent-T1 mapping values were compared between the two groups.
Results: The mean apparent-T1 mapping values of the kidneys were significantly higher in patients with chronic HBV infection compared to the control group (1445 ± 129 ms vs. 1306 ± 115 ms, P = 0.003). Inter-class correlation coefficient measurement analysis showed excellent agreement.
Conclusion: Renal apparent-T1 mapping MRI may help show the early stage of renal parenchymal disease without apparent renal dysfunction in chronic HBV infection. |
| first_indexed | 2024-04-10T10:38:44Z |
| format | Article |
| id | doaj.art-3c51829b09984c0189f6e103c87dcaae |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T10:38:44Z |
| publishDate | 2022-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-3c51829b09984c0189f6e103c87dcaae2023-02-15T16:20:43ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312022-03-0139211512010.4274/balkanmedj.galenos.2021.2021-6-133Non-invasive Assessment of Subclinical Renal Parenchymal Changes in Chronic Hepatitis B Virus By T1 Mapping Magnetic Resonance ImagingSerçin Özkök0https://orcid.org/0000-0002-2176-5278Ayşenur Buz1https://orcid.org/0000-0003-1324-2810Servet Erdemli2https://orcid.org/0000-0001-5545-768XGülşah Şaşak Kuzgun3https://orcid.org/0000-0003-4395-4368Ahmet Aslan4https://orcid.org/0000-0003-1433-6149Department of Radiology, Göztepe Training and Research Hospital, İstanbul Medeniyet University, İstanbul, TurkeyDepartment of Radiology, Göztepe Training and Research Hospital, İstanbul Medeniyet University, İstanbul, TurkeyDepartment of Radiology, Göztepe Training and Research Hospital, İstanbul Medeniyet University, İstanbul, TurkeyDepartment of Nephrology, Göztepe Training and Research Hospital, İstanbul Medeniyet University, İstanbul, TurkeyDepartment of Radiology, Göztepe Training and Research Hospital, İstanbul Medeniyet University, İstanbul, TurkeyBackground: Renal parenchymal changes are seen in chronic hepatitis B virus (HBV) infection, and its disease diagnosis should be confirmed by renal biopsy, which is an invasive technique. Apparent-T1 mapping magnetic resonance imaging (MRI) is an established imaging technique that assesses subclinical tissue injury without using a contrast agent. Aims: To investigate the early stage subclinical renal changes without apparent renal dysfunction in patients with chronic HBV infection by renal apparent-T1 mapping MRI. Study Design: A cross-sectional study. Methods: This study included 45 participants with normal kidney function, wherein 25 have biopsy-proven chronic HBV hepatitis and 20 are healthy individuals. Liver and kidney biochemical tests were performed within 1 month before the MRI scan, and the estimated glomerular filtration rate was calculated by diet modification in renal disease formula. Breath-hold, electrocardiogram-gated Modified Look-Locker Imaging sequence was acquired in the coronal plane without contrast agent administration. Apparent-T1 mapping value was measured by manually drawing a region of interest in six points for both kidneys by two observers. Apparent-T1 mapping values were compared between the two groups. Results: The mean apparent-T1 mapping values of the kidneys were significantly higher in patients with chronic HBV infection compared to the control group (1445 ± 129 ms vs. 1306 ± 115 ms, P = 0.003). Inter-class correlation coefficient measurement analysis showed excellent agreement. Conclusion: Renal apparent-T1 mapping MRI may help show the early stage of renal parenchymal disease without apparent renal dysfunction in chronic HBV infection.https://balkanmedicaljournal.org/text.php?lang=en&id=2381 |
| spellingShingle | Serçin Özkök Ayşenur Buz Servet Erdemli Gülşah Şaşak Kuzgun Ahmet Aslan Non-invasive Assessment of Subclinical Renal Parenchymal Changes in Chronic Hepatitis B Virus By T1 Mapping Magnetic Resonance Imaging Balkan Medical Journal |
| title | Non-invasive Assessment of Subclinical Renal Parenchymal Changes in Chronic Hepatitis B Virus By T1 Mapping Magnetic Resonance Imaging |
| title_full | Non-invasive Assessment of Subclinical Renal Parenchymal Changes in Chronic Hepatitis B Virus By T1 Mapping Magnetic Resonance Imaging |
| title_fullStr | Non-invasive Assessment of Subclinical Renal Parenchymal Changes in Chronic Hepatitis B Virus By T1 Mapping Magnetic Resonance Imaging |
| title_full_unstemmed | Non-invasive Assessment of Subclinical Renal Parenchymal Changes in Chronic Hepatitis B Virus By T1 Mapping Magnetic Resonance Imaging |
| title_short | Non-invasive Assessment of Subclinical Renal Parenchymal Changes in Chronic Hepatitis B Virus By T1 Mapping Magnetic Resonance Imaging |
| title_sort | non invasive assessment of subclinical renal parenchymal changes in chronic hepatitis b virus by t1 mapping magnetic resonance imaging |
| url | https://balkanmedicaljournal.org/text.php?lang=en&id=2381 |
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