Aquaporin-3 and Aquaporin-5 Facilitate Migration and Cell–Cell Adhesion in Pancreatic Cancer by Modulating Cell Biomechanical Properties

Aquaporin-3 and Aquaporin-5 Facilitate Migration and Cell–Cell Adhesion in Pancreatic Cancer by Modulating Cell Biomechanical Properties

Background: Aquaporins are membrane channels responsible for the bidirectional transfer of water and small non-charged solutes across cell membranes. AQP3 and AQP5 are overexpressed in pancreatic ductal adenocarcinoma, playing key roles in cell migration, proliferation, and invasion. Here, we evalua...

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Bibliographic Details
Main Authors: Patrícia M. Silva, Inês V. da Silva, Maria J. Sarmento, Ítala C. Silva, Filomena A. Carvalho, Graça Soveral, Nuno C. Santos
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
aquaporins
aquaglyceroporins
hydrogen peroxide
pancreatic cancer
cell–cell adhesion
membrane fluidity
Online Access:https://www.mdpi.com/2073-4409/11/8/1308

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