Correlation Between Interleukin 6 and Interleukin 10 in Acute Myocardial Infarction
The aim of this study was to analyze (i) ratios between pro-inflammatory cytokines interleukin 6 (IL-6), interleukin 1 (IL-1), tumour necrosis factor α (TNF-α) and anti-inflammatory cytokine interleukin 10 (IL-10) in patients with acute myocardial infarction (AMI) and stable angina pectoris (ii) as...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2009-11-01
|
| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/2784 |
| _version_ | 1797260813663207424 |
|---|---|
| author | Larisa Dizdarević-Hudić Zumreta Kušljugić Fahir Baraković Selmira Brkić Damir Sabitović Elmir Jahić Maida Isabegović Elnur Smajić Igor Hudić Katarina Divković |
| author_facet | Larisa Dizdarević-Hudić Zumreta Kušljugić Fahir Baraković Selmira Brkić Damir Sabitović Elmir Jahić Maida Isabegović Elnur Smajić Igor Hudić Katarina Divković |
| author_sort | Larisa Dizdarević-Hudić |
| collection | DOAJ |
| description | The aim of this study was to analyze (i) ratios between pro-inflammatory cytokines interleukin 6 (IL-6), interleukin 1 (IL-1), tumour necrosis factor α (TNF-α) and anti-inflammatory cytokine interleukin 10 (IL-10) in patients with acute myocardial infarction (AMI) and stable angina pectoris (ii) as well as correlation between IL-6 and IL-10 in AMI and (iii) correlation between IL-6 and lipoproteins in AMI.
The total of 71 patients were enrolled in this study, 41 of them with AMI (study group) and 30 with stable angina pectoris (control group). The concentrations of cytokines and lipoproteins were measured from blood samples. Pro-inflammatory to anti-inflammatory cytokine ratios were calculated by dividing concentrations of pro-inflammatory cytokines with IL-10. In statistical analyses we used descriptive statistics, normality tests and analysis of correlation.
IL-6: IL-10 ratio is significantly higher in AMI than in stable angina (P < 0,001), TNF-α: IL-10 is also higher in study group but the difference is not significant. We found positive linear correlation between IL-6 and IL-10 (r =0,43; p = 0,015) and negative linear correlation between IL-6 and high density lipoprotein HDL (r = -0,47; p= 0,008) in AMI.
IL-6: IL-10 ratio is higher in AMI than in stable angina. There is linear correlation between IL-6 and IL-10 and IL-6 and HDL in AMI.
|
| first_indexed | 2024-04-24T23:31:17Z |
| format | Article |
| id | doaj.art-3c5193c1d2404f8ba971e28f5638bf1a |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:31:17Z |
| publishDate | 2009-11-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-3c5193c1d2404f8ba971e28f5638bf1a2024-03-15T14:37:08ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2009-11-019410.17305/bjbms.2009.2784477Correlation Between Interleukin 6 and Interleukin 10 in Acute Myocardial InfarctionLarisa Dizdarević-Hudić0Zumreta Kušljugić1Fahir Baraković2Selmira Brkić3Damir Sabitović4Elmir Jahić5Maida Isabegović6Elnur Smajić7Igor Hudić8Katarina Divković9Department of Cardiology, Clinic of Internal Medicine, University Clinics Centre TuzlaDepartment of Cardiology, Clinic of Internal Medicine, University Clinics Centre TuzlaDepartment of Cardiology, Clinic of Internal Medicine, University Clinics Centre TuzlaDepartment of Pathophysiology, Faculty of Medicine, University of TuzlaDepartment of Immunology and Microbiology, University Clinics Centre TuzlaDepartment of Cardiology, Clinic of Internal Medicine, University Clinics Centre TuzlaDepartment of Cardiology, Clinic of Internal Medicine, University Clinics Centre TuzlaDepartment of Cardiology, Clinic of Internal Medicine, University Clinics Centre TuzlaDivison of Reproductive Immunology, Clinic for Gynaecology and Obstetrics, University Clinics Centre TuzlaDepartment of Cardiology, Clinic of Internal Medicine, University Clinics Centre TuzlaThe aim of this study was to analyze (i) ratios between pro-inflammatory cytokines interleukin 6 (IL-6), interleukin 1 (IL-1), tumour necrosis factor α (TNF-α) and anti-inflammatory cytokine interleukin 10 (IL-10) in patients with acute myocardial infarction (AMI) and stable angina pectoris (ii) as well as correlation between IL-6 and IL-10 in AMI and (iii) correlation between IL-6 and lipoproteins in AMI. The total of 71 patients were enrolled in this study, 41 of them with AMI (study group) and 30 with stable angina pectoris (control group). The concentrations of cytokines and lipoproteins were measured from blood samples. Pro-inflammatory to anti-inflammatory cytokine ratios were calculated by dividing concentrations of pro-inflammatory cytokines with IL-10. In statistical analyses we used descriptive statistics, normality tests and analysis of correlation. IL-6: IL-10 ratio is significantly higher in AMI than in stable angina (P < 0,001), TNF-α: IL-10 is also higher in study group but the difference is not significant. We found positive linear correlation between IL-6 and IL-10 (r =0,43; p = 0,015) and negative linear correlation between IL-6 and high density lipoprotein HDL (r = -0,47; p= 0,008) in AMI. IL-6: IL-10 ratio is higher in AMI than in stable angina. There is linear correlation between IL-6 and IL-10 and IL-6 and HDL in AMI. https://www.bjbms.org/ojs/index.php/bjbms/article/view/2784cytokinesanti-inflammatorypro-inflammatoryHDLacute myocardial infarction |
| spellingShingle | Larisa Dizdarević-Hudić Zumreta Kušljugić Fahir Baraković Selmira Brkić Damir Sabitović Elmir Jahić Maida Isabegović Elnur Smajić Igor Hudić Katarina Divković Correlation Between Interleukin 6 and Interleukin 10 in Acute Myocardial Infarction Biomolecules & Biomedicine cytokines anti-inflammatory pro-inflammatory HDL acute myocardial infarction |
| title | Correlation Between Interleukin 6 and Interleukin 10 in Acute Myocardial Infarction |
| title_full | Correlation Between Interleukin 6 and Interleukin 10 in Acute Myocardial Infarction |
| title_fullStr | Correlation Between Interleukin 6 and Interleukin 10 in Acute Myocardial Infarction |
| title_full_unstemmed | Correlation Between Interleukin 6 and Interleukin 10 in Acute Myocardial Infarction |
| title_short | Correlation Between Interleukin 6 and Interleukin 10 in Acute Myocardial Infarction |
| title_sort | correlation between interleukin 6 and interleukin 10 in acute myocardial infarction |
| topic | cytokines anti-inflammatory pro-inflammatory HDL acute myocardial infarction |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/2784 |
| work_keys_str_mv | AT larisadizdarevichudic correlationbetweeninterleukin6andinterleukin10inacutemyocardialinfarction AT zumretakusljugic correlationbetweeninterleukin6andinterleukin10inacutemyocardialinfarction AT fahirbarakovic correlationbetweeninterleukin6andinterleukin10inacutemyocardialinfarction AT selmirabrkic correlationbetweeninterleukin6andinterleukin10inacutemyocardialinfarction AT damirsabitovic correlationbetweeninterleukin6andinterleukin10inacutemyocardialinfarction AT elmirjahic correlationbetweeninterleukin6andinterleukin10inacutemyocardialinfarction AT maidaisabegovic correlationbetweeninterleukin6andinterleukin10inacutemyocardialinfarction AT elnursmajic correlationbetweeninterleukin6andinterleukin10inacutemyocardialinfarction AT igorhudic correlationbetweeninterleukin6andinterleukin10inacutemyocardialinfarction AT katarinadivkovic correlationbetweeninterleukin6andinterleukin10inacutemyocardialinfarction |