Clinical observations of vitreoretinal surgery for four different phenotypes of X-linked congenital retinoschisis
AIM: To evaluate the outcomes of vitreoretinal surgery for four different phenotypes of X-linked retinoschisis (XLRS). METHODS: This study included thirty-one eyes of 25 patients who developed XLRS with severe complications. Among the 31 eyes, there were 7 eyes with vitreous hemorrhage, 8 eyes with...
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Press of International Journal of Ophthalmology (IJO PRESS)
2018-06-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://www.ijo.cn/en_publish/2018/6/20180615.pdf |
| _version_ | 1828526053668159488 |
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| author | Chen Zhao Qi Zhang Hai-Ying Jin Pei-Quan Zhao |
| author_facet | Chen Zhao Qi Zhang Hai-Ying Jin Pei-Quan Zhao |
| author_sort | Chen Zhao |
| collection | DOAJ |
| description | AIM: To evaluate the outcomes of vitreoretinal surgery for four different phenotypes of X-linked retinoschisis (XLRS).
METHODS: This study included thirty-one eyes of 25 patients who developed XLRS with severe complications. Among the 31 eyes, there were 7 eyes with vitreous hemorrhage, 8 eyes with retinal detachment and vitreous hemorrhage, and 16 eyes with rhegmatogenous retinal detachment. All of the patients underwent standard three-port pars plana vitrectomy. All of the eyes were divided into 4 groups before surgery according to a modified classification scheme, with the first three groups as follows: group A, with foveal cystic schisis; group B with macular lamellar schisis; and group C with foveolamellar changes. Peripheral schisis was not present in these 3 groups; however, group D was a complex group with both macular and peripheral changes. One year after surgery, we analyzed the best corrected visual acuity and postoperative anatomical and functional outcomes of these 4 groups.
RESULTS: There were 7 eyes in group A (22.6%), 1 eye in group B (3.2%), 15 eyes in group C (48.4%) and 8 eyes in group D (25.8%). Postoperative anatomical and functional outcomes were satisfactory at the last visit, while the mean visual acuity was increased to 0.27±0.11, with a significant difference (t=-1.049, P=0.000) compared with the results before surgery (0.1±0.08). Visual acuity was improved in 23 eyes (74.2%). Complications were found in three eyes: two eyes with proliferative vitreoretinopathy and traction retinal detachment 10 and 12mo after surgery, respectively; and one eye with vitreous hemorrhage 15mo after surgery. These eyes were in groups C and D. The retinas remained attached in these 3 eyes after reoperation.
CONCLUSION: We should pay greater attention to XLRS with foveolamellar changes because it is the most changeable phenotype. Once complications occur, vitreoretinal surgery can significantly improve visual acuity and restore the anatomic structure of the retina. |
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| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-11T21:17:46Z |
| publishDate | 2018-06-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
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| series | International Journal of Ophthalmology |
| spelling | doaj.art-3c5260245b9d40c2a15d0f50dfa187282022-12-22T00:50:33ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982018-06-0111698699010.18240/ijo.2018.06.15Clinical observations of vitreoretinal surgery for four different phenotypes of X-linked congenital retinoschisisChen Zhao0Qi Zhang1Hai-Ying Jin2Pei-Quan Zhao3Department of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, ChinaDepartment of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, ChinaDepartment of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, ChinaDepartment of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, ChinaAIM: To evaluate the outcomes of vitreoretinal surgery for four different phenotypes of X-linked retinoschisis (XLRS). METHODS: This study included thirty-one eyes of 25 patients who developed XLRS with severe complications. Among the 31 eyes, there were 7 eyes with vitreous hemorrhage, 8 eyes with retinal detachment and vitreous hemorrhage, and 16 eyes with rhegmatogenous retinal detachment. All of the patients underwent standard three-port pars plana vitrectomy. All of the eyes were divided into 4 groups before surgery according to a modified classification scheme, with the first three groups as follows: group A, with foveal cystic schisis; group B with macular lamellar schisis; and group C with foveolamellar changes. Peripheral schisis was not present in these 3 groups; however, group D was a complex group with both macular and peripheral changes. One year after surgery, we analyzed the best corrected visual acuity and postoperative anatomical and functional outcomes of these 4 groups. RESULTS: There were 7 eyes in group A (22.6%), 1 eye in group B (3.2%), 15 eyes in group C (48.4%) and 8 eyes in group D (25.8%). Postoperative anatomical and functional outcomes were satisfactory at the last visit, while the mean visual acuity was increased to 0.27±0.11, with a significant difference (t=-1.049, P=0.000) compared with the results before surgery (0.1±0.08). Visual acuity was improved in 23 eyes (74.2%). Complications were found in three eyes: two eyes with proliferative vitreoretinopathy and traction retinal detachment 10 and 12mo after surgery, respectively; and one eye with vitreous hemorrhage 15mo after surgery. These eyes were in groups C and D. The retinas remained attached in these 3 eyes after reoperation. CONCLUSION: We should pay greater attention to XLRS with foveolamellar changes because it is the most changeable phenotype. Once complications occur, vitreoretinal surgery can significantly improve visual acuity and restore the anatomic structure of the retina.http://www.ijo.cn/en_publish/2018/6/20180615.pdf990X-linked retinoschisiscomplicationsvitreoretinal surgery |
| spellingShingle | Chen Zhao Qi Zhang Hai-Ying Jin Pei-Quan Zhao Clinical observations of vitreoretinal surgery for four different phenotypes of X-linked congenital retinoschisis International Journal of Ophthalmology 990 X-linked retinoschisis complications vitreoretinal surgery |
| title | Clinical observations of vitreoretinal surgery for four different phenotypes of X-linked congenital retinoschisis |
| title_full | Clinical observations of vitreoretinal surgery for four different phenotypes of X-linked congenital retinoschisis |
| title_fullStr | Clinical observations of vitreoretinal surgery for four different phenotypes of X-linked congenital retinoschisis |
| title_full_unstemmed | Clinical observations of vitreoretinal surgery for four different phenotypes of X-linked congenital retinoschisis |
| title_short | Clinical observations of vitreoretinal surgery for four different phenotypes of X-linked congenital retinoschisis |
| title_sort | clinical observations of vitreoretinal surgery for four different phenotypes of x linked congenital retinoschisis |
| topic | 990 X-linked retinoschisis complications vitreoretinal surgery |
| url | http://www.ijo.cn/en_publish/2018/6/20180615.pdf |
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