Targeting Endothelial Cells with Multifunctional GaN/Fe Nanoparticles
Abstract In this paper, we report on the interaction of multifunctional nanoparticles with living endothelial cells. The nanoparticles were synthesized using direct growth of gallium nitride on zinc oxide nanoparticles alloyed with iron oxide followed by core decomposition in hydrogen flow at high t...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2017-08-01
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| Series: | Nanoscale Research Letters |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s11671-017-2262-y |
| _version_ | 1797709798998802432 |
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| author | Tudor Braniste Ion Tiginyanu Tibor Horvath Simion Raevschi Birgit Andrée Serghei Cebotari Erin C. Boyle Axel Haverich Andres Hilfiker |
| author_facet | Tudor Braniste Ion Tiginyanu Tibor Horvath Simion Raevschi Birgit Andrée Serghei Cebotari Erin C. Boyle Axel Haverich Andres Hilfiker |
| author_sort | Tudor Braniste |
| collection | DOAJ |
| description | Abstract In this paper, we report on the interaction of multifunctional nanoparticles with living endothelial cells. The nanoparticles were synthesized using direct growth of gallium nitride on zinc oxide nanoparticles alloyed with iron oxide followed by core decomposition in hydrogen flow at high temperature. Using transmission electron microscopy, we demonstrate that porcine aortic endothelial cells take up GaN-based nanoparticles suspended in the growth medium. The nanoparticles are deposited in vesicles and the endothelial cells show no sign of cellular damage. Intracellular inert nanoparticles are used as guiding elements for controlled transportation or designed spatial distribution of cells in external magnetic fields. |
| first_indexed | 2024-03-12T06:42:06Z |
| format | Article |
| id | doaj.art-3c534bd20c2947ec984de2a1b921b880 |
| institution | Directory Open Access Journal |
| issn | 1931-7573 1556-276X |
| language | English |
| last_indexed | 2024-03-12T06:42:06Z |
| publishDate | 2017-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-3c534bd20c2947ec984de2a1b921b8802023-09-03T00:54:13ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2017-08-011211610.1186/s11671-017-2262-yTargeting Endothelial Cells with Multifunctional GaN/Fe NanoparticlesTudor Braniste0Ion Tiginyanu1Tibor Horvath2Simion Raevschi3Birgit Andrée4Serghei Cebotari5Erin C. Boyle6Axel Haverich7Andres Hilfiker8National Center for Materials Study and Testing, Technical University of MoldovaNational Center for Materials Study and Testing, Technical University of MoldovaLeibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical SchoolDepartment of Physics and Engineering, State University of MoldovaLeibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical SchoolLeibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical SchoolLeibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical SchoolLeibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical SchoolLeibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical SchoolAbstract In this paper, we report on the interaction of multifunctional nanoparticles with living endothelial cells. The nanoparticles were synthesized using direct growth of gallium nitride on zinc oxide nanoparticles alloyed with iron oxide followed by core decomposition in hydrogen flow at high temperature. Using transmission electron microscopy, we demonstrate that porcine aortic endothelial cells take up GaN-based nanoparticles suspended in the growth medium. The nanoparticles are deposited in vesicles and the endothelial cells show no sign of cellular damage. Intracellular inert nanoparticles are used as guiding elements for controlled transportation or designed spatial distribution of cells in external magnetic fields.http://link.springer.com/article/10.1186/s11671-017-2262-yNanoparticlesGallium nitrideEndothelial cellsEncapsulationCell guiding |
| spellingShingle | Tudor Braniste Ion Tiginyanu Tibor Horvath Simion Raevschi Birgit Andrée Serghei Cebotari Erin C. Boyle Axel Haverich Andres Hilfiker Targeting Endothelial Cells with Multifunctional GaN/Fe Nanoparticles Nanoscale Research Letters Nanoparticles Gallium nitride Endothelial cells Encapsulation Cell guiding |
| title | Targeting Endothelial Cells with Multifunctional GaN/Fe Nanoparticles |
| title_full | Targeting Endothelial Cells with Multifunctional GaN/Fe Nanoparticles |
| title_fullStr | Targeting Endothelial Cells with Multifunctional GaN/Fe Nanoparticles |
| title_full_unstemmed | Targeting Endothelial Cells with Multifunctional GaN/Fe Nanoparticles |
| title_short | Targeting Endothelial Cells with Multifunctional GaN/Fe Nanoparticles |
| title_sort | targeting endothelial cells with multifunctional gan fe nanoparticles |
| topic | Nanoparticles Gallium nitride Endothelial cells Encapsulation Cell guiding |
| url | http://link.springer.com/article/10.1186/s11671-017-2262-y |
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